Effects of Enoxaparin and aspirin on the prevention of miscarriage in women with Polycystic Ovarian Syndrome and a history of two or more miscarriages

Articles in Press

Document Type : Original Article

Authors

1 Obstetric and Gynecology Department,, Kurdistan University of Medical Science, sanandaj,, Iran.

2 Clinical Research Development Unit, Besat Hospital, Kurdistan Medical Science.

10.22038/ijogi.2025.78202.6019

Abstract

Abstract:

BACKGROUND & OBJECTIVE: Recurrent miscarriage is a reproductive medicine problem The etiology of recurrent miscarriage is often unknown and needs different diagnostic and therapeutic strategies. The purpose of this study was to evaluate the effects of aspirin and enoxaparin in preventing recurrent miscarriage.

METHODS: This cross-sectional descriptive study was conducted on 20 infertile women with polycystic ovarian syndrome who had two or more previous miscarriages. In these patients, hysterosalpingography, thyroid studies, and prolactin levels were normal, and evaluation of acquired thrombophilia was negative. They were included in the study after obtaining written informed consent. During clomiphene or letrozole-gonadotropin ovulation, the patient was taking aspirin 80 mg/day. After confirmation of intrauterine pregnancy by ultrasonography, aspirin was discontinued and enoxaparin 40-80 mg/day was administered subcutaneously. Patients were monitored for pregnancy outcomes. The analysis was done using SPSS tools. Standard t-test, chi-square, and Fisher's test were used for quantitative and qualitative analysis. The significance level for this study was P<0.05.

RESULTS: The mean age of patients was 31.8 ± 4.85 years. 11 women had two, 16 women had three, and 3 patients had four miscarriages. After treatment, 80% of patients had full-term pregnancies and 20% had miscarriages. A greater reduction in miscarriage was seen in patients with four miscarriages.

CONCLUSIONS: This study showed that enoxaparin and aspirin therapy were effective in preventing miscarriage.

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 17 May 2025

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