Relationship between obesity and the risk of breast cancer: A case-control study

Document Type : Original Article

Authors

1 Assistant Professor, Department of Thoracic Surgery, Clinical Research Development Unit (CRDU), 5azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran.

2 Medical Student, Clinical Research Development Unit (CRDU), 5azar Hospital, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

3 Clinical Research Development Unit (CRDU), 5azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran. PhD Student of Reproductive Health, Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

10.22038/ijogi.2025.83996.6260

Abstract

Introduction: Several mechanisms are involved in the effect of obesity on the occurrence of breast cancer as well as its effect on cancer mortality. Since there are contradictory results  in this field, its effectiveness is still debated. Therefore, the present study was conducted with aim to determine the relationship between obesity and the risk of breast cancer in patients referred to the educational and medical centers in Gorgan.Methods: In this case-control study, 140 qualified people were enrolled in two groups with breast cancer (n=70) and those without breast cancer (n=70). Height, weight and body mass index of two groups were measured before the surgery. Demographic information and histological results were collected by a checklist and then analyzed with SPSS software (version 16) and chi-square test and One-way ANOVA. P<0.05 was considered significant.
Results: The mean weight in women with and without breast cancer was 75.76±11.53 and 71.39±10.26 kg, respectively (P=0.019). Also, the mean body mass index of patients with and without breast cancer was 28.68±4.27 and 27.19 ± 3.84 kg/m2 (P=0.032). The incidence of hypertension (P=0.001) and hyperlipidemia (P=0.004) was more common in patients with breast cancer.
Conclusion: The results of the present study showed that the mean weight and body mass index was higher in  patients with breast cancer than those without breast cancer. Also, the incidence of hypertension and hyperlipidemia was more common in the breast cancer group.

Keywords

Main Subjects

References

  1. Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA, Minihan A, et al. Breast cancer statistics, 2022. CA: a cancer journal for clinicians 2022; 72(6):524-41.
  2. Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, et al. Current and future burden of breast cancer: Global statistics for 2020 and 2040. The Breast 2022; 66:15-23.
  3. Kazeminia M, Salari N, Hosseinian-Far A, Akbari H, Bazrafshan MR, Mohammadi M. The prevalence of breast cancer in Iranian women: a systematic review and meta-analysis. Indian Journal of Gynecologic Oncology 2022; 20(1):14.
  4. Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanisławek A. Breast cancer—epidemiology, risk factors, classification, prognostic markers, and current treatment strategies—an updated review. Cancers 2021; 13(17):4287.
  5. Rodrigues I, Fernandes R, Ferreira A, Pereira D, Fernandes R, Soares R, et al. Is Progesterone Receptor a Neglected Feature in Breast Cancer? A Retrospective Study Analysing the Clinicopathological Characteristics of Breast Cancer Based on Progesterone Receptor Status. Clinical Breast Cancer 2024.
  6. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. Jama 2010; 303(3):235-41.
  7. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. Jama 2014; 311(8):806-14.
  8. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. The lancet 2014; 384(9945):766-81.
  9. World Health Organization. Obesity and overweight [http://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight]. Accessed 26 Feb 2019.
  10. Picon‐Ruiz M, Morata‐Tarifa C, Valle‐Goffin JJ, Friedman ER, Slingerland JM. Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA: a cancer journal for clinicians 2017; 67(5):378-97.
  11. Mirzazadeh A, Sadeghirad B, Haghdoust AA, Bahreyni F, Rezazadeh KM. The prevalence of obesity in Iran in recent decade; a systematic review and meta-analysis study. Iranian J Publ Health 2009; 38(3):1-11.
  12. World Health Organization. Obesity and overweight Genova: World Health Organization; 2018 [Available from: https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight.
  13. Hajian K, Gholizadehpasha A, Bozorgzadeh SH. Association of obesity and central obesity with breast cancer risk in pre-and postmenopausal women. Journal of Babol University of medical sciences 2013; 15(3):7-15.
  14. Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body fatness and cancer—viewpoint of the IARC Working Group. New England journal of medicine 2016; 375(8):794-8.
  15. Van Den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. American journal of epidemiology 2000; 152(6):514-27.
  16. Lahmann PH, Hoffmann K, Allen N, Van Gils CH, Khaw KT, Tehard B, et al. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). International journal of cancer 2004; 111(5):762-71.
  17. White AJ, Nichols HB, Bradshaw PT, Sandler DP. Overall and central adiposity and breast cancer risk in the Sister Study. Cancer 2015; 121(20):3700-8.
  18. Sebastiani F, Cortesi L, Sant M, Lucarini V, Cirilli C, De Matteis E, et al. Increased incidence of breast cancer in postmenopausal women with high body mass index at the Modena Screening Program. Journal of Breast Cancer 2016; 19(3):283-91.
  19. Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, et al. Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the women’s health initiative randomized clinical trials. JAMA oncology 2015; 1(5):611-21.
  20. Suzuki R, Orsini N, Saji S, Key TJ, Wolk A. Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status—a meta‐analysis. International journal of cancer 2009; 124(3):698-712.
  21. Renehan AG, Roberts DL, Dive C. Obesity and cancer: pathophysiological and biological mechanisms. Archives of physiology and biochemistry 2008; 114(1):71-83.
  22. Karatas F, Erdem GU, Sahin S, Aytekin A, Yuce D, Sever AR, et al. Obesity is an independent prognostic factor of decreased pathological complete response to neoadjuvant chemotherapy in breast cancer patients. The Breast 2017; 32:237-44.
  23. Biglia N, Peano E, Sgandurra P, Moggio G, Pecchio S, Maggiorotto F, et al. Body mass index (BMI) and breast cancer: impact on tumor histopatologic features, cancer subtypes and recurrence rate in pre and postmenopausal women. Gynecological Endocrinology 2013; 29(3):263-7.
  24. Chen H, Yuan M, Quan X, Chen D, Yang J, Zhang C, et al. The relationship between central obesity and risk of breast cancer: a dose–response meta-analysis of 7,989,315 women. Frontiers in Nutrition 2023; 10:1236393.
  25. Nagrani R, Mhatre S, Rajaraman P, Soerjomataram I, Boffetta P, Gupta S, et al. Central obesity increases risk of breast cancer irrespective of menopausal and hormonal receptor status in women of South Asian Ethnicity. European Journal of Cancer 2016; 66:153-61.
  26. Rosner B, Eliassen AH, Toriola AT, Chen WY, Hankinson SE, Willett WC, et al. Weight and weight changes in early adulthood and later breast cancer risk. International journal of cancer 2017; 140(9):2003-14.
  27. Renehan AG, Pegington M, Harvie MN, Sperrin M, Astley SM, Brentnall AR, et al. Young adulthood body mass index, adult weight gain and breast cancer risk: the PROCAS Study (United Kingdom). British journal of cancer 2020; 122(10):1552-61.
  28. Ayoub NM, Yaghan RJ, Abdo NM, Matalka II, Akhu-Zaheya LM, Al-Mohtaseb AH. Impact of obesity on Clinicopathologic characteristics and disease prognosis in pre‐and postmenopausal breast cancer patients: a retrospective institutional study. Journal of obesity 2019; 2019(1):3820759.
  29. Sun L, Zhu Y, Qian Q, Tang L. Body mass index and prognosis of breast cancer: An analysis by menstruation status when breast cancer diagnosis. Medicine 2018; 97(26):e11220.
  30. Kamineni A, Anderson ML, White E, Taplin SH, Porter P, Ballard-Barbash R, et al. Body mass index, tumor characteristics, and prognosis following diagnosis of early-stage breast cancer in a mammographically screened population. Cancer Causes & Control 2013; 24:305-12.
  31. Kaviani A, Neishaboury M, Mohammadzadeh N, Ansari-Damavandi M, Jamei K. Effects of obesity on presentation of breast cancer, lymph node metastasis and patient survival: a retrospective review. Asian Pacific Journal of Cancer Prevention 2013; 14(4):2225-9.
  32. Chowdhury FA, Islam MF, Prova MT, Khatun M, Sharmin I, Islam KM, et al. Association of hyperlipidemia with breast cancer in Bangladeshi women. Lipids in health and disease 2021; 20(1):52.
  33. Akalanka HM, Ekanayake S, Samarasinghe K. Could anthropometric and lipid parameters reflect susceptibility to breast cancer? Comparison of newly diagnosed breast cancer and apparently healthy women. Asian Pacific journal of cancer prevention: APJCP 2018; 19(9):2475.
  34. Narii N, Zha L, Komatsu M, Kitamura T, Sobue T, Ogawa T. Cholesterol and breast cancer risk: a cohort study using health insurance claims and health checkup databases. Breast Cancer Research and Treatment 2023; 199(2):315-22.
  35. His M, Dartois L, Fagherazzi G, Boutten A, Dupré T, Mesrine S, et al. Associations between serum lipids and breast cancer incidence and survival in the E3N prospective cohort study. Cancer Causes & Control 2017; 28:77-88.
  36. Nelson ER, Chang CY, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends in Endocrinology & Metabolism 2014; 25(12):649-55.
  37. Wei Y, Huang Y, Yang W, Huang Q, Chen Y, Zeng K, et al. The significances and clinical implications of cholesterol components in human breast cancer. Science Progress 2021; 104(3):00368504211028395.
  38. Zhong S, Zhang X, Chen L, Ma T, Tang J, Zhao J. Statin use and mortality in cancer patients: Systematic review and meta-analysis of observational studies. Cancer treatment reviews 2015; 41(6):554-67.
  39. Wu QJ, Tu C, Li YY, Zhu J, Qian KQ, Li WJ, et al. Statin use and breast cancer survival and risk: a systematic review and meta-analysis. Oncotarget 2015; 6(40):42988.
  40. Islam MM, Yang HC, Nguyen PA, Poly TN, Huang CW, Kekade S, et al. Exploring association between statin use and breast cancer risk: an updated meta-analysis. Archives of gynecology and obstetrics 2017; 296:1043-53.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 28, Issue 2
April 2025
Pages 22-34

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