Investigation of sonographic and mammographic findings of Brest cancers with the response to neoadjuvant chemotherapy and Immunohistochemistry (IHC) markers based on the pathologist's report.

Articles in Press

Document Type : Original Article

Authors

Mashhad University of Medical Sciences, Mashhad, iran

10.22038/ijogi.2025.83294.6232

Abstract

Introduction:

Neoadjuvant chemotherapy aims to shrink tumors, allowing breast-conserving surgery and targeting micrometastases. This study investigated the correlation between initial radiological findings and chemotherapy response.



Materials and Methods:

Patients with breast cancer at Omid Hospital were included In this descriptive and analytical study. Response to neoadjuvant chemotherapy was assessed using the CAP protocol (0-3). Immunohistochemistry markers were also evaluated.



Results:

151 female patients with breast cancer who were candidates for neoadjuvant chemotherapy participated in this descriptive-analytical study. A significant correlation was observed between the mean of her2neu and Ki67 with the mammographic shape of the mass and between the expression level of ER and PR with the Brest mammographic composition. Also, a statistically significant correlation was observed between the average ER with the sonographic shape of the mass and the average Ki67 and ER with the sonographic margin of the mass. The sonographic margin of the mass also showed a significant decreasing trend with the response to neoadjuvant chemotherapy in patients with breast cancer.



Conclusion:

There was a statistically significant relationship between mammographic mass shape and composition with IHC markers and sonographic mass shape and margin with the amount of IHC markers. Also, the number of patients with worse response to treatment was significantly less than the groups with better response to treatment in the oval group.

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 23 April 2025

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