Expression of PD-1, PD-L1 Markers and their Relationship with Clinicopathologic Factors in Endometrial Cancer

Document Type : Original Article

Authors

1 Professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Associate Professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Assistant Professor, Department of Molecular Medicine, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Resident, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/ijogi.2024.80445.6114

Abstract

Introduction: Programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) are immunomodulator molecules that have been the focus of research in lung cancer, melanoma, and renal cell cancer. The present study was conducted with aim to investigate the immunohistochemical expression of PD-1 and PDL-1 in endometrial cancer and its relationship with clinical and pathological findings.
Methods: This cross-sectional study comprised 91 patients with endometrial cancer admitted to Qaem Hospital in Mashhad between April 2022 and March 2024. By referring to the medical record and calling the patients, information was collected about age, tumor status and survival of the patients. Expression of markers was assessed by immunohistochemistry method. Data analysis was done using SPSS (version 23) and chi-square, Fisher's exact, t-test and Spearman and Pearson correlation tests. P<0.05 was considered significant.
Results: There was no significant relationship between the expression of the two markers PD-1 and PD-L1 and the characteristics of age, histological type, tumor size, vascular invasion, myometrial invasion, FIGO stage and survival (p>0.05). However, there was a statistically significant correlation between the lack of expression of PD-1 and PD-L1 with the disease grade (p<0.05).
Conclusion: Negative PD-1 and PDL-1 expression correlated with FIGO grade 1. According to the findings of the present study, evaluation of the expression of PD-1 and PDL-1 markers requires further studies with larger sample size and long-term follow-up.

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Main Subjects

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 27, Issue 10
December 2024
Pages 1-16

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