A survey relationship between the size of the fetal nasal bone in first and second trimester ultrasound and down syndrome in perinatology clinic of Sabzevar University of Medical Science in 2016-2020

Articles in Press

Document Type : Original Article

Authors

1 Department of Obstetrics & Gynecology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

2 General practitioner, Student Research Committee, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

3 General practitioner, Student Research Committee, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. 3734-4136

4 Department of Midwifery / School of Nursing and Midwifery / Sabzevar University of Medical Sciences / Sabzevar / Iran

10.22038/ijogi.2024.75445.5883

Abstract

Introduction: The size of the length of the nasal bone to detect chromosomal abnormalities is different for each ethnic race. Materials and methods: This cross-sectional study was conducted in 265 patients between 1995 and 1999. Absence of fetal nasal bone in the first trimester ultrasound or hypoplasia of the fetal nasal bone in the second trimester ultrasound was the criteria for entering the study. The information of these people was extracted from their sampling file and included in the checklist designed by the researchers and all calculations were done with Stata software version 16. Results: The average age of the participants in the study was 30.65 ± 7.04. 83 people (31.3%) did not see the nasal bone in the first trimester ultrasound and the rest (68.7%) had hypoplasia of the nasal bone in the second trimester. Out of 83 cases of nasal bone not visible in first trimester ultrasound, 59 (71.1%) had normal genetics and 16 (19.3%) had Down syndrome. The rest had other abnormalities. 178 people (97.8%) of the fetuses with hypoplasia in the second trimester ultrasound were normal in terms of karyotype after genetic examination, and 4 people (2%) had genetic abnormalities including Down syndrome and other chromosomal abnormalities. There was a relationship between the position of the fetal nasal bone in the first trimester ultrasound and genetic abnormalities (P<0.001). There was no significant relationship between fetal nasal bone hypoplasia in second trimester ultrasound and genetic results (P=0.10

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 13 November 2024

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