Comparative study of carotid artery intima-media thickness of pregnant women with preeclampsia and healthy pregnant and non-pregnant women in Kermanshah Imam Reza hospital

Document Type : Original Article

Authors

1 Associate Professor, Department of Radiology, Clinical Research Development Center, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

2 Resident, Department of Radiology, Clinical Research Development Center, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

3 Research assistant, Department of Radiology, Clinical Research Development Center, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

Introduction: Preeclampsia is a multisystemic disorder with unknown cause in pregnant women that has dangerous complications for mother and fetus. Contradictory studies have been reported about increasing carotid artery intimal media thickness in the preeclamptic pregnant women. The present study was conducted with aim to compare carotid artery intima-media thickness of pregnant women with preeclampsia and healthy pregnant and non-pregnant women.
Methods: This cross-sectional analytical study was performed in 2019 and 2020 on 21 preeclamptic pregnant women, 21 healthy pregnant with normal blood pressure and 21 non-pregnant women with normal blood pressure. The intima-media thickness of the carotid artery of the subjects was measured in 3 areas of the common carotid artery on both sides and its mean was recorded. Data were analyzed by SPSS software (version 16) and Kolmogorov-Smirnov, ANOVA, independent t, and Kruskal-Wallis tests. P<0.05 was considered significant.
Results: Based on the results of Kruskal-Wallis test, the minimum, maximum and mean thickness of carotid artery intima media in preeclamptic pregnant women was (0.4, 0.8, 0.600),  in healthy pregnant (0.3, 0.4, 0.300), and in non-pregnant women was (0.2, 0.5, 0.300) (P <0.001).
Conclusion: The thickness of intima media of carotid artery was significantly different among the three groups.

Keywords

Main Subjects

References

  1. Gaugler-Senden IP, Berends AL, de Groot CJ, Steegers EA. Severe, very early onset preeclampsia: subsequent pregnancies and future parental cardiovascular health. European Journal of Obstetrics & Gynecology and Reproductive Biology 2008; 140(2):171-7.
  2. Asgharnia M, Mirbolouk F, Salamat F, Darabian B. Investigating the relationship between glucose-6-phosphate dehydrogenase and preeclampsia. The Iranian Journal of Obstetrics, Gynecology and Infertility 2013; 16(65):1-7.
  3. Weissgerber TL, Milic NM, Milin-Lazovic JS, Garovic VD. Impaired flow-mediated dilation before, during, and after preeclampsia: a systematic review and meta-analysis. Hypertension 2016; 67(2):415-23.
  4. Lawler J, Osman M, Shelton JA, Yeh J. Population-based analysis of hypertensive disorders in pregnancy. Hypertension in pregnancy 2007; 26(1):67-76.
  5. Amirian T, Rahgozar S, Shahshahan Z. Preeclampsia in a Cellular and Molecular View. Journal of Isfahan Medical School 2013; 31(234):568-80.
  6. World Health Organization. The World Health Report 2005: Make every mother and child count. World Health Organization; 2005.
  7. Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia/eclampsia. InSeminars in perinatology 2012; 36(1):56-59.
  8. Antza C, Cifkova R, Kotsis V. Hypertensive complications of pregnancy: a clinical overview. Metabolism 2018; 86:102-11.
  9. Sharemi SH, Milani F, Zahiri Z, Zendedel M, Salamat F, Rafipour B, et al. Comparison of pre-eclampsia risk factors regarding to its severity in pregnant women referred to Alzahra Hospital of Rasht, Iran, 2012. The Iranian Journal of Obstetrics, Gynecology and Infertility 2013; 16(69):1-8.
  10. Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. Williams Obstetrics. Translated by: Ghazi Jahani B, Ghotbi R. Tehran: Golban Medical Publication; 2014. P. 510-12.
  11. Gersh BJ, Sliwa K, Mayosi BM, Yusuf S. Novel therapeutic concepts the epidemic of cardiovascular disease in the developing world: global implications. European heart journal 2010; 31(6):642-8.
  12. Tarzamni MK, Salehi R, Givian F, Farhang S. Association of carotid intima-media thickness with the presence and severity of coronary artery disease. Neurosciences Journal 2006; 11(4):308-11.
  13. Afiat M, Esmailpour E, Jarahi L, Pourali L, Iranmanesh G, Daghighi N, Layegh P. Comparison of carotid artery intima media thickness in preeclamptic patients with healthy normotensive pregnant women. The Iranian Journal of Obstetrics, Gynecology and Infertility 2017; 20(6):1-7.
  14. Haukkamaa L, Moilanen L, Kattainen A, Luoto R, Kähönen M, Leinonen M, et al. Pre-eclampsia is a risk factor of carotid artery atherosclerosis. Cerebrovascular diseases 2009; 27(6):599-607.
  15. Verissimo C. Intima-media thickness and hypertensive disorders of pregnancy: a prospective study. Revista Portuguesa de Cirurgia Cardio-toracica e Vascular: Orgao Oficial da Sociedade Portuguesa de Cirurgia Cardio-toracica e Vascular 2010; 17(2):123-8.
  16. Stergiotou I, Crispi F, Valenzuela-Alcaraz B, Bijnens B, Gratacos E. Patterns of maternal vascular remodeling and responsiveness in early-versus late-onset preeclampsia. American journal of obstetrics and gynecology 2013; 209(6):558-e1.
  17. Yuan LJ, Xue D, Duan YY, Cao TS, Yang HG, Zhou N. Carotid arterial intima–media thickness and arterial stiffness in pre‐eclampsia: analysis with a radiofrequency ultrasound technique. Ultrasound in Obstetrics & Gynecology 2013; 42(6):644-52.
  18. Čerkez Habek J, Vuković Bobić M, Habek D, Tikvica Luetić A, Košuta M. Intima media thickness in women with preeclampsia. Medica Jadertina 2018; 48(1-2):39-42.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 27, Issue 7
September 2024
Pages 1-7

Files

Share

How to cite

Statistics