The Role of Microbiota on Women's Reproductive Health: Defense Mechanisms, Pathogenesis, and Its Importance in Uterine Adhesion: A Systematic Review

Document Type : Review Article

Authors

1 M.Sc. Student of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Ph.D of Microbiology, Management Affairs of Laboratories of Vice President of Treatment, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Professor, Department of Physiology, Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/ijogi.2024.77392.5968

Abstract

Introduction: About 9% of the total microbiota of the body is the microbiota of the reproductive system. The microbiota of the female genital tract plays an important role in health and disease. An imbalance of vaginal microbiota leads to disorders such as intrauterine adhesions (IUA) that its common clinical symptom includes amenorrhea, infertility, and pelvic pain. The present study was conducted with aim to investigate the role of uterine microbiota in the defense system, different diseases, and pathogenesis of uterine adhesions.
Methods: In this review article, studies related to vaginal microbiota and intrauterine adhesions were searched in PubMed, Scopus, EMBASE, Web of Knowledge, and MeSH databases using keywords of Vaginal Microbiota, Uterine microbiota, Intrauterine adhesions, and Dysbiosis.
Results: Microbiota through different mechanisms affects human physiological processes such as metabolism, infection, and immune system. Lactobacillus is the dominant microbiota of the genital tract, which creates an acidic environment that prevents the growth of harmful bacteria. The composition of microbiota can change under the influence of factors such as age and hormones, and any factor such as irrational use of antibiotics disturbs the balance of microbiota and leads to diseases such as uterine adhesions.
Conclusion: An imbalance in the bocy microbiota including the reproductive system can cause complications such as uterine adhesions. A complete understanding of the mechanism of the microbiota of the reproductive system in the development, treatment and prevention of women's diseases requires more clinical studies in the future.

Keywords

Main Subjects

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 27, Issue 8
October 2024
Pages 81-100

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