Introduction: The microbiota of the female genital tract, including the vagina and uterine cavity, play an important role in health and disease. An imbalance in the vaginal microbiota potentially leads to different disorders like intrauterine adhesions (IUA). Uterine adhesions can occur following surgery, trauma, infection, or antibiotic therapy. The present study is a comprehensive review of the research carried out in the field of the role of the microbiota of the uterus in creating adhesions.
Methods: In this article, a review of studies that describe vaginal microbiota and intrauterine adhesions (IUA) in PubMed, Scopus, EMBASE, Web of Knowledge, and MeSH databases using keywords: Vaginal Microbiota, Uterine microbiota, Intrauterine adhesions, Dysbiosis were searched. There was no time limit in this study and at the end the data was qualitatively reviewed.
Results: Different studies show that about 9% of the body microbiota is composed of the microbiota of the genital tract. Lactobacillus is the dominant microbiota of the vagina among different types of bacterial strains. However, genital microbiota dysbiosis is mainly characterized by the loss of these bacterial species and the imbalance of microbial diversity. Irrational and arbitrary use of antibiotics can disrupt the balance of microbiota and lead to diseases like uterine adhesions.
Conclusion: Dysbiosis of the vaginal microbiota occurs following high accumulation of Gardnerella and Proteus, while low accumulation of Lactobacillus, leads to diseases like uterine adhesions. Diet, lifestyle, drugs, and environmental factors are among the factors affecting the diversity and function of microbiota.
Eshtad, E., Yaghoubi, A., & Khazaei, M. (2024). The role of genital tract microbiota in adhesion development. The Iranian Journal of Obstetrics, Gynecology and Infertility, (), -. doi: 10.22038/ijogi.2024.77392.5968
MLA
Elaheh Eshtad; Atieh Yaghoubi; Majid Khazaei. "The role of genital tract microbiota in adhesion development", The Iranian Journal of Obstetrics, Gynecology and Infertility, , , 2024, -. doi: 10.22038/ijogi.2024.77392.5968
HARVARD
Eshtad, E., Yaghoubi, A., Khazaei, M. (2024). 'The role of genital tract microbiota in adhesion development', The Iranian Journal of Obstetrics, Gynecology and Infertility, (), pp. -. doi: 10.22038/ijogi.2024.77392.5968
VANCOUVER
Eshtad, E., Yaghoubi, A., Khazaei, M. The role of genital tract microbiota in adhesion development. The Iranian Journal of Obstetrics, Gynecology and Infertility, 2024; (): -. doi: 10.22038/ijogi.2024.77392.5968
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