بررسی نظام‌مند اثرات دریافت مونوسدیم گلوتامات بر تعداد، غلظت، مورفولوژی و حرکت اسپرم در موش‌های صحرایی نر: مروری نظام‌مند

نوع مقاله : مروری

نویسندگان

1 دانشجوی کارشناسی ارشد علوم و صنایع غذایی، کمیته تحقیقات دانشجویی، دانشکده علوم تغذیه و صنایع غذایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 استادیار گروه تغذیه سلولی مولکولی، دانشکده علوم تغذیه و صنایع غذایی، انستیتو تحقیقات تغذیه‌ای و صنایع غذایی کشور، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: ناباروری مردان، یک مشکل جهانی جدی در سلامت مردان است که در آن یک یا چند جزء از دستگاه تناسلی مردانه اختلال عملکردی دارند و یا کمتر از حد انتظار عمل می­ کنند. نوع تغذیه می ­تواند به­ طور مثبت یا منفی بر باروری اثرگذار باشد و این تأثیر به جنبه­ های کمّی و کیفی یک دریافت­ های غذایی بستگی دارد. مرور نظام ­مند حاضر با هدف تعیین اثرات دریافت مونوسدیم گلوتامات بر تعداد، غلظت، مورفولوژی و حرکت اسپرم در موش ­های صحرایی نر انجام شد.
روش‌کار: در این مرور نظام­ مند، کلیدواژه­ های مرتبط با ناباروری مردان، مونوسدیم گلوتامات، موش ­های صحرایی نر، تعداد اسپرم، اسپرم زنده، مورفولوژی اسپرم و حرکت اسپرم در پایگاه­ های اطلاعاتی انگلیسی و فارسی زبانMedline ، Embase،Google Scholar ، Web of Science، Science Direct،Scopus ،Magiran ،SID ، ISC و Cochrane از ماه ژانویه 2010 تا ماه می 2023 مورد جستجو قرار گرفت.
یافته­ ها: در این مرور نظام­ مند، 14 مطالعه بررسی شد. یافته­ های این مطالعات نشان داد که مصرف مونوسدیم گلوتامات می­ تواند منجر به کاهش تعداد اسپرم و درصد اسپرم­ های زنده و همچنین تغییر در مورفولوژی اسپرم­ ها در موش­ های صحرایی نر شود. نتایج اکثر مطالعات حاکی از کاهش تحرک اسپرم ­ها با مصرف این افزودنی غذایی بود، اما در برخی مطالعات، با مصرف مونوسدیم گلوتامات افزایش در تحرک اسپرم­ ها مشاهده شد.
نتیجه­ گیری: افزایش دریافت مونوسدیم گلوتامات منجر به کاهش تعداد، غلظت و تحرک اسپرم در موش ­های صحرایی نر می‌شود که به­ طور بالقوه در افزایش نرخ ناباروری نقش دارد. در نتیجه، مصرف دوزهای بالا و طولانی‌مدت مونوسدیم گلوتامات می­ تواند به­ طور معنی­ داری ویژگی­ های اسپرم را تغییر دهد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

A systematic review on the effects of monosodium glutamate on quantity, concentration, morphology, and motility of sperm in male rats

نویسندگان [English]

  • Aref Adeli Mosabbeb 1
  • Ghazaleh Eslamian 2
  • Fatemeh Habibollahi 1
  • Kiana Hasibi 1
  • Sepehr Khoshbaf Khiabanian 1
  • Bentolhosna Dehghan nayeri 1
1 M.Sc. Student of Food Sciences and Industry, Student Research Committee, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Assistant Professor, Department of Cellular and Molecular Nutrition, School of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Male infertility is a significant global issue affecting men's health, characterized by dysfunction or suboptimal performance of components of the male reproductive system. Types of nutrition can affect positively or negatively on fertility and this effect depends on the quality and quantity of food intake. The present systematic review was conducted with aim to investigate the effects of monosodium glutamate consumption on sperm quantity, concentration, morphology, and motility in male rats.
Methods: In this systematic review, search was conducted on English and Persian databases of Medline, Embase, Google Scholar, Web of Science, Science Direct, Scopus, Magiran, SID, ISC, and Cochrane from January 2010 to May 2023 with the keywords related to male infertility, monosodium glutamate, male rats, sperm count, live sperm, sperm morphology, and sperm motility.
Results: Fourteen studies were included in this systematic review. The findings indicated that monosodium glutamate consumption was associated with decreased sperm count, live sperm percentage, and alterations in sperm morphology in male rats. Most studies reported a decrease in sperm motility with monosodium glutamate intake, although some studies observed an increase in sperm motility.
Conclusion: Increased consumption of monosodium glutamate is linked to reductions in sperm quantity, concentration, and motility in male rats, potentially contributing to elevated infertility rates. Therefore, prolonged and high-dose consumption of monosodium glutamate may significantly impact sperm characteristics.

کلیدواژه‌ها [English]

  • Male infertility
  • Male rats
  • Monosodium glutamate
  • Sperm

مراجع

  1. Babakhanzadeh E, Nazari M, Ghasemifar S, Khodadadian A. Some of the factors involved in male infertility: a prospective review. International journal of general medicine 2020: 29-41.
  2. Abangah G, Rashidian T, Nasirkandy MP, Azami M. A meta-analysis of the prevalence and etiology of infertility in Iran. International Journal of Fertility & Sterility 2023; 17(3):160.
  3. Rizk FH, Soliman NA, Abo-Elnasr SE, Mahmoud HA, Abdel Ghafar MT, Elkholy RA, et al. Fisetin ameliorates oxidative glutamate testicular toxicity in rats via central and peripheral mechanisms involving SIRT1 activation. Redox Report 2022; 27(1):177-85.
  4. Ferramosca A, Zara V. Diet and male fertility: the impact of nutrients and antioxidants on sperm energetic metabolism. International journal of molecular sciences 2022; 23(5):2542.
  5. Hosseini B, Eslamian G. Association of dietary factors with male and female infertility: review of current evidence. Thrita 2014; 3(3).
  6. Hosseini B, Eslamian G. Association of micronutrient intakes with female infertility: review of recent evidence. Thrita 2015;4(1).
  7. Kheradmand N, Nadi Z, Baazm M. The role of free radicals and antioxidants in male and female fertility disorders: review study. The Iranian Journal of Obstetrics, Gynecology and Infertility 2021; 24(2):96-106.
  8. Gharghanipour S, Taebi M, Salehi P, Heidari-Beni M. Relationship between dietary antioxidant intake and semen analysis parameters. The Iranian Journal of Obstetrics, Gynecology and Infertility 2018; 21(6):47-54.
  9. Kayode OT, Rotimi DE, Kayode AA, Olaolu TD, Adeyemi OS. Monosodium glutamate (MSG)-induced male reproductive dysfunction: a mini review. Toxics 2020; 8(1):7.
  10. Jubaidi FF, Mathialagan RD, Noor MM, Taib IS, Budin SB. Monosodium glutamate daily oral supplementation: Study of its effects on male reproductive system on rat model. Systems biology in reproductive medicine 2019; 65(3):194-204.
  11. Oyeniran DO, Ojewale AO, Akingbade AM, Dare BJ, Adelaja MA, Oseni LO. The ameliorative potentials of aqueous leaf extract of Amaranthus hybridus on monosodium glutamate-induced testicular damage in Wistar rats. JBRA Assisted Reproduction 2022; 26(3):469-74.
  12. Mahdi Histological and Molecular study for detection of Inh-b genes in Male rats treated with Monosodium Glutamate. Journal of Pharmaceutical Sciences and Research 2018; 10(12):3317-20.
  13. Koohpeyma F, Gholizadeh F, Hafezi H, Hajiaghayi M, Siri M, Allahyari S, et al. The protective effect of L-carnitine on testosterone synthesis pathway, and spermatogenesis in monosodium glutamate-induced rats. BMC Complementary Medicine and Therapies 2022; 22(1):269.
  14. Kianifard D, Saiah GV, Rezaee F. Study of the protective effects of quince (cydonia oblonga) leaf extract on fertility alterations and gonadal dysfunction induced by monosodium glutamate in adult male wistar rats. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 2015; 22(4):375-84.
  15. Helal AM, Abdel-Latif MS, Abomughaid MM, Ghareeb DA, El-Sayed MM. Potential therapeutic effects of Ulva lactuca water fraction on monosodium glutamate-induced testicular and prostatic tissue damage in rats. Environmental Science and Pollution Research 2021; 28:29629-42.
  16. Gad FA, Farouk SM, Emam MA. Antiapoptotic and antioxidant capacity of phytochemicals from Roselle (Hibiscus sabdariffa) and their potential effects on monosodium glutamate-induced testicular damage in rat. Environmental Science and Pollution Research 2021; 28:2379-90.
  17. El-Sawy HB, Soliman MM, El-Shazly SA, Ali HA. Protective effects of camel milk and vitamin E against monosodium glutamate induced biochemical and testicular dysfunctions. Progress in Nutrition.2018; 20(1):76-85.
  18. Iamsaard S, Sukhorum W, Samrid R, Yimdee J, Kanla P, Chaisiwamongkol K, et al. The sensitivity of male rat reproductive organs to monosodium glutamate. Acta Med Acad 2014; 43(1):3-9.
  19. Sarhan The ameliorating effect of sodium selenite on the histological changes and expression of caspase-3 in the testis of monosodium glutamate-treated rats: Light and electron microscopic study. Journal of microscopy and ultrastructure 2018; 6(2):105-15.
  20. Sakr SA, Badawy GM. Protective effect of curcumin on monosodium glutamate-induced reproductive toxicity in male albino rats. Global J Pharmacol 2013; 7(4):416-22.
  21. Alalwani Monosodium glutamate induced testicular lesions in rats (histological study). Middle East Fertility Society Journal 2014; 19(4):274-80.
  22. Abd-Elkareem M, Aljazzar A, Amer AS, Abd El‑Rahman MA. Cytoprotective effects of Nigella sativa seeds on monosodium glutamate induced seminal vesicle damages: Histological and immunohistochemical studies. Authorea Preprints 2023.
  23. Al-Shahari EA, El-Kott AF. Potential effect of grape seeds extract against monosodium glutamate induced infertility in rats. International Journal of Pharmacology 2019; 15(2):287-294.
  24. Ekaluo U, Ikpeme E, Ibiang Y, Amaechina O. Attenuating role of vitamin C on sperm toxicity induced by. J Biol Sci. 2013; 13(4):298-301.
  25. Igwebuike UM, Ochiogu IS, Ihedinihu BC, Ikokide JE, Idika IK. The effects of oral administration of monosodium glutamate (msg) on the testicular morphology and cauda epididymal sperm reserves of young and adult male rats. Veterinarski arhiv 2011; 81(4):525-34.
  26. Ismail Assessment of DNA damage in testes from young Wistar male rat treated with monosodium glutamate. Life Sci J 2012; 9(1):930-9.
  27. Giovambattista A, Suescun MO, Nessralla CC, França LR, Spinedi E, Calandra RS. Modulatory effects of leptin on leydig cell function of normal and hyperleptinemic rats. Neuroendocrinology 2003; 78(5):270-9.
  28. Nayanatara AK, Vinodini NA, Damodar G, Ahemed B, Ramaswamy GR, Shabarianth S, et al. Role of ascorbic acid in monosodium glutamate mediated effect on testicular weight, sperm morphology and sperm count, in rat testis. Journal of Chinese Clinical Medicine 2008; 3(1):1-5.
  29. Aini S, Marhendra AP, Rahayu S. Curcuma mangga Ethanol Extract Improves Sperm Quality of Mice Exposed to Monosodium Glutamate. The Journal of Experimental Life Science 2022; 12(3):98-104.
  30. Wang CX, Zhang Y, Li QF, Sun HL, Chong HL, Jiang JX, et al. The reproductive toxicity of monosodium glutamate by damaging GnRH neurons cannot be relieved spontaneously over time. Drug design, development and therapy 2021: 3499-508.
  31. Tolulope OD, Ebiwonjumi O, Oluwatoyin AL, Dupe AO, Victor AM, Grace A, et al. Disruptive consequences of monosodium glutamate on male reproductive function: A Review. Current Research in Toxicology 2024: 100148.
مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 7
مهر 1403
صفحه 67-81

فایل ها

هم رسانی

ارجاع به این مقاله

آمار