Correlation of estradiol level with clinical characteristics of postmenopausal bleeding women with endometrial malignancies in Imam Hossein (AS) hospital in 2023

Articles in Press

Document Type : Original Article

Authors

1 Semnan UMS

2 شیراز

10.22038/ijogi.2024.79972.6092

Abstract

Introduction: Considering the relatively high importance and complications of endometrial malignancies, especially during menopause, and considering that the role of endocrine hormones was not fully clarified, this study aims to determine the relationship between estradiol levels and the characteristics of Clinical study of postmenopausal bleeding women with endometrial malignancy was performed.

Methods: This analytical-cross-sectional study was conducted on 54 patients with postmenopausal bleeding suffering from endometrial malignancy who referred to Imam Hossein (AS) hospital in 2023, according to the inclusion criteria, using the full enumeration method. Demographic, clinical and serum estradiol levels of patients were collected.

Results: Serum estradiol level was 26.80 ± 15.77 pg/ml (median: 26.30, lowest: 6.7 and highest: 124.9 pg/ml). In the normal estradiol group compared to abnormal estradiol, the prevalence of endometrial thickness ≥ 4 mm (0.73 vs. 100% and p = 0.018) and family history of uterine malignancy (35.2 vs. 83.8% and p = 0.026) p = 0/0), was less. The most common type of pathology in both groups was grade 1 endometrioid adenocarcinoma, and this difference was not significant (p = 0.780).

Conclusion: Considering the relationship between estradiol level with high thickness of the endometrium and family history of uterine malignancy, further investigation of the role of this hormone in endometrial malignancies is suggested.

Keywords: Endometrial malignancy, estradiol, post-menopause, abnormal uterine bleeding

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 20 July 2024

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