Probiotics and urinary tract infections in postmenopausal women: a systematic review

Document Type : Review Article

Authors

1 PhD Student of Reproductive Health, Midwifery and Reproductive Health Research Center, Students Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 M.Sc. in Midwifery, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

3 Assistant Professor, Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

10.22038/ijogi.2024.77426.6081

Abstract

Introduction: Urinary tract infections (UTIs) are a common disease and extensive studies have been done on the effect of probiotics on the control and treatment of UTIs. This review study was performed with aim to explore the effect of probiotics on UTIs in postmenopausal women.
Methods: In order to find the relevant papers written in 2000 to 2022, international databases of Web of Science Embase، Scopus، Google Scholar, PubMed and national databases of Irandoc، Magiran، SID، IranMedex were investigated with different combinations of keywords related to "Urinary tract infection" and "Probiotic". Selection of papers was done based on inclusion and exclusion criteria and the quality of papers was assessed using Verhagen scale.
Results: Finally, five papers with the total sample size of 419 subjects were investigated. Most of the studies were in English and all of them were RCT. According to most studies, probiotics do not have a preventive role in the occurrence of urinary infections in postmenopausal women. However, probiotics alongside antibiotic compounds can be used to treat UTIs in postmenopausal women.
Conclusion: Despite the inconsistent results, most studies have shown that probiotics do not play a role in urinary infections in postmenopausal women. Differences in the amount and number of daily consumption as well as type and number of probiotic strains used have led to different results. In this regard, it is suggested to conduct extensive studies to explore the role of probiotics on post-menopausal women’s UTI.

Keywords

Main Subjects

References

  1. Gupta K, Grigoryan L, Trautner B. Urinary Tract Infection. Ann Intern Med 2017; 167(7):ITC49-ITC64.
  2. Mody L, Juthani-Mehta M. Urinary tract infections in older women: a clinical review. Jama 2014; 311(8):844-54.
  3. Rowe TA, Juthani-Mehta M. Urinary tract infection in older adults. Aging health 2013; 9(5):519-28.
  4. Alamolhoda SH, Zare E, Hakimzadeh A, Zalpour A, Vakili F, Azadeh H, Ebadifard R, Chermahini RM, Nasiri M. The effect of herbal medicines on treatment of hot flashes in postmenopausal women: a systematic review and meta-analysis. Iran J Obstet Gynecol Infertil 2022; 25(10):81-93.
  5. Borchert D, Sheridan L, Papatsoris A, Faruquz Z, Barua JM, Junaid I, et al. Prevention and treatment of urinary tract infection with probiotics: review and research perspective. Indian Journal of Urology 2008; 24(2):139-44.
  6. Patangia DV, Anthony Ryan C, Dempsey E, Paul Ross R, Stanton C. Impact of antibiotics on the human microbiome and consequences for host health. Microbiologyopen 2022; 11(1):e1260.
  7. Singh VP, Sharma J, Babu S, Rizwanulla, Singla A. Role of probiotics in health and disease: a review. J Pak Med Assoc 2013; 63(2):253-7.
  8. Manzoor S, Wani SM, Mir SA, Rizwan D. Role of probiotics and prebiotics in mitigation of different diseases. Nutrition 2022; 96:111602.
  9. Santoro N, Roeca C, Peters BA, Neal-Perry G. The menopause transition: signs, symptoms, and management options. The Journal of Clinical Endocrinology & Metabolism 2021; 106(1):1-5.
  10. Phillips NA, Bachmann GA. The genitourinary syndrome of menopause. Menopause 2021; 28(5):579-88.
  11. Pabich WL, Fihn SD, Stamm WE, Scholes D, Boyko EJ, Gupta K. Prevalence and determinants of vaginal flora alterations in postmenopausal women. The Journal of infectious diseases 2003; 188(7):1054-8.
  12. Anger J, Lee U, Ackerman AL, Chou R, Chughtai B, Clemens JQ, et al. Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU guideline. The Journal of urology 2019; 202(2):282-9.
  13. Mainini G, Passaro M, Schiattarella A, De Franciscis P, Di Donna MC, Trezza G. Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus. Menopause Review/Przegląd Menopauzalny 2020; 19(3):130-4.
  14. ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM, Prins JM, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Archives of internal medicine 2012; 172(9):704-12.
  15. Ng QX, Peters C, Venkatanarayanan N, Goh YY, Ho CY, Yeo WS. Use of Lactobacillus spp. to prevent recurrent urinary tract infections in females. Medical hypotheses 2018; 114:49-54.
  16. Akgül T, Karakan T. The role of probiotics in women with recurrent urinary tract infections. Turkish journal of urology 2018; 44(5):377.
  17. Verhagen AP, De Vet HC, De Bie RA, Kessels AG, Boers M, Bouter LM, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. Journal of clinical epidemiology 1998; 51(12):1235-41.
  18. den Heijer CD, Geerlings SE, Prins JM, Beerepoot MA, Stobberingh EE, Penders J. Can the composition of the intestinal microbiota predict the development of urinary tract infections?. Future microbiology 2016; 11(11):1395-404.
  19. ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM, Prins JM, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Archives of internal medicine 2012; 172(9):704-12.
  20. Talebi TM, Niksolat M, Minaeian S, Khodabandelou N, Zandieh Z. The effect of probiotics in the prevention of urinary tract infections in elderly patients hospitalized in intensive care units. Razi Journal of Medical Sciences 2017; 24(156):32-41.
  21. Kuzmenko AV, Kuzmenko VV, Gyaurgiev TA. Experience of application of hormonal and probiotic therapy in the complex treatment of women in periand postmenopausal with chronic recurrent bacterial cystitis in the background of vulvovaginal atrophy. Urologiia 2019 ;15(3):66-71.
  22. Colodner R, Edelstein H, Chazan B, Raz R. Vaginal colonization by orally administered Lactobacillus rhamnosus GG. Imaj-Ramat Gan 2003; 5(11):767-9.
  23. Heller KJ. Probiotic bacteria in fermented foods: product characteristics and starter organisms. The American journal of clinical nutrition 2001; 73(2):374s-9s.
  24. Sarmast Ghahfarokhi E, Mobini Dehkordi M, Beheshtimaal K. Isolation and evaluation of lactic acid production content in native Lactobacillus of Chaharmahal va Bakhtiari province isolated from dairy products. Journal of Microbial Biology 2012; 1(3):41-52.
  25. Abedi D, Feizizadeh S, Akbari V, Jafarian-Dehkordi A. In vitro anti-bacterial and anti-adherence effects of Lactobacillus delbrueckii subsp bulgaricus on Escherichia coli. Research in pharmaceutical sciences 2013; 8(4):260.
  26. Sadri M, Arbab Soleimani N, Forghanifard MM. The study of Antimicrobial and Anti-adhesive effect of ProbioticLactobacilli on Uropathogenic Escherichia coli (UPEC). Journal of Microbial Biology 2016; 5(17):159-70.
  27. Timmerman HM, Niers LE, Ridwan BU, Koning CJ, Mulder L, Akkermans LM, et al. Design of a multispecies probiotic mixture to prevent infectious complications in critically ill patients. Clinical Nutrition 2007; 26(4):450-9.
  28. Amdekar S, Singh V, Singh DD. Probiotic therapy: immunomodulating approach toward urinary tract infection. Current microbiology 2011; 63:484-90.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 27, Issue 6
August 2024
Pages 68-77

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