Comparison of pregnancy success in women with poor ovarian response under double ovarian stimulation or two consecutive conventional stimulations: a single-center retrospective study.

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Document Type : Original Article

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hemat street

10.22038/ijogi.2024.78628.6026

Abstract

Background: In some cases, patients have poor ovarian response, so it is necessary to obtain the right number of oocytes with proper stimulation. The number of oocytes obtained is directly related to fertility success. In this study, the comparison of two methods of double stimulation and regular sequential stimulation and their relationship with pregnancy outcomes has been evaluated.



Material and methods: This prospective cohort study was conducted in Shariati Hospital in Tehran from 2021-2022. A total of 140 women with poor ovarian response based on Bologna criteria and underwent oocyte puncture were selected for in vitro fertilization. Among these, 70 women with double stimulation and 70 women with two consecutive normal stimulations after embryo transfer were compared in terms of clinical pregnancy rate and cumulative live birth rate.

Result: The results showed that although the percentage of clinical pregnancy and live birth was higher in the group under double stimulation, however, no significant relationship was observed between them. It was also found that the number of MII oocytes and follicles greater than 14 mm and the number of frozen embryos in the group under double stimulation was higher compared to the other group, which was statistically significant (p<0.05).

Conclusion: In general, it can be said that double stimulation compared to regular sequential stimulation had no superiority in pregnancy outcomes, including chemical and clinical pregnancy. However, it can increase the number of MII eggs, follicles larger than 14 mm and the number of frozen embryos.

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 06 July 2024

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