Comparison of intravenous administration of Metoclopramide VS ondansetron on prevention of nausea and/or vomiting in patients undergoing elective cesarean section under spinal anesthesia

Articles in Press

Document Type : Original Article

Authors

1 Anesthesiology critical care and Pain Management Research Centre, Hormozgan University of medical science, Bandar Abbas, Iran

2 Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

10.22038/ijogi.2024.75221.5871

Abstract

Background: Nausea and vomiting are common side effects of caesarean section with spinal anaesthesia. This study compared the effect of intravenous metoclopramide and ondansetron in preventing nausea and vomiting in elective cesarean section with spinal anaesthesia.

Methods: This study was a double-blind, randomized clinical trial with a control group of 150 pregnant women candidates for elective cesarean section. The patients were randomly divided into three groups. 5 minutes before spinal anaesthesia, group I received IV metoclopramide 10mg, Group II received IV Ondansetron 4mg, and group III received IV normal saline. The incidence and number of episodes of nausea and vomiting, vital signs and amount of ephedrine consumption Were compared at 1,2,4 and 6 hours after the operation.

Results: There was a statistically significant difference in the incidence of nausea and/or vomiting between the studied groups in the first hour (P=0.014). The incidence of nausea and/or vomiting during the first hour after surgery in the control group was 50%, in the ondansetron group, 40% and in the metoclopramide group, 22%. No statistically significant difference was observed between the groups in terms of the incidence of nausea and/or vomiting in the following hours. In addition, there was no statistically significant difference between the groups regarding the incidence of hypotension and the amount of ephedrine consumed.

Conclusions: Intravenous injection of metoclopramide 10 mg before spinal anaesthesia in elective cesarean section reduces the incidence of nausea and/or vomiting more than ondansetron in the first hour after the operation.

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 01 June 2024

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