Investigating the Effect of Oral Probiotic Capsules on Postpartum Depression in Primiparous women: A Three-blind Randomized Control trial

Document Type : Original Article


1 department of midwifery, school of nursing and midwifery, mashhad university of medical sciences, mashhad, iran

2 Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 PhD in Biostatistics - Faculty of Health



Introduction: The postpartum period is the most critical period for mental problems and depression. It seems that probiotics can affect mental health by changing the intestinal microbial flora; Therefore, the present study was conducted with the aim of determining the effectiveness of oral probiotic capsule on postpartum depression of primiparous women

Methods: This randomized, triple-blind clinical trial study was conducted on 60 eligible primiparous women who had just given birth in the 2nd and 3rd health centers of Mashhad from August to November 2023. Participants were randomly assigned to two groups of probiotics and a placebo group through permutation blocks of 4. The drug group consisted of 30 people from the third day after giving birth, one capsule of probiotics per day and the placebo group with 30 people received placebo capsules for 30 days. The Edinburgh postpartum depression questionnaire was completed by two groups before and after the intervention. Analyzes were performed using SPSS version 25 statistical software. The p-value of less than 0.05 was considered significant.

Findings: Both groups were homogeneous in terms of demographic and obstetric characteristics. The average score of depression before the intervention in both drug and placebo groups was without statistically significant difference. After the intervention, the mean score of depression in the placebo group was 4.56±4.33 and in the drug group was 0.40±1.00 with a statistically significant difference (p=0.0001).

Conclusion: Consuming probiotic capsules can reduce women's depression in the postpartum period.


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