Early recurrence of adult type ovarian granulosa cell tumor in the sigmoid colon: a case report

Document Type : Case report

Authors

1 Department of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Obstetrics and Gynecology, Mashhad University of Medical Science, Mashhad, Iran

10.22038/ijogi.2024.77915.5989

Abstract

Introduction: Ovarian granulosa cell tumors (GCT) include 2-3% of ovarian cancers. In this study, a rare case of granulosa at the age of 35 with early recurrence in the sigmoid colon is reported.

Patient report: A 35-year-old female, Noli Gravid, with a history of primary infertility, was referred to Ghaem Hospital in Mashhad, Iran, with a complaint of abdominal pain. With the diagnosis of ovarian mass, she underwent laparotomy. The intraoperative frozen examination was ovarian granulosa tumor. Right salpingo-opheretomy with surgical staging and endometrial curettage were done. The final pathology was adult-type granulosa tumor and other samples were normal. 3 cycles of chemotherapy were performed. After 18 months, she returned with a complaint of abdominal pain. An 8 cm mass on the left side of the pelvis was reported. She candidated for surgery. there was a mass attached to the meso of the sigmoid colon. Frozen analysis reported the recurrence of the granulosa tumor. A total hysterectomy with a left salpingo-oophorectomy was performed. Then she underwent pelvic radiotherapy.

Conclusion: Recurrence is the main cause of death in patients with ovarian granulosa tumors. Due to late recurrence, patients should be trained to pay attention to the symptoms of recurrence. long-term follow-up is needed for early diagnosis of recurrence. Considering the rare cases of extra-pelvic and extra-genital recurrences, there is a need for new treatment strategies to be carried out in the form of clinical trials to improve the quality of life of patients and prevent frequent recurrences leading to their mortality.

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 13 April 2024

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