The effect of different doses of estrogen in the prevention of adhesion recurrence after hysteroscopic lysis in Asherman's syndrome: a clinical trial study.

Document Type : Original Article

Authors

1 Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IRAN.

2 mashhad university of medical sciences

3 , Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IRAN.

10.22038/ijogi.2024.74507.5851

Abstract

The aim of this study was to compare the effect of two different doses of estrogen (2.5 mg and 5 mg daily) in preventing the recurrence of adhesions after hysteroscopic lysis in Asherman's syndrome.

In this randomized controlled clinical trial study, patients with moderate and severe Asherman's syndrome were investigated in Imam Reza Hospital, Mashhad between 2016 and 2016.Patients underwent hysteroscopy to remove adhesions, all patients received postoperative estrogen therapy for 30 days (and medroxyprogesterone 10 mg daily for the last 10 days). Patients were randomly assigned to two groups of estrogen 2.5 mg and 5 mg daily. After the end of the treatment period, with hysteroscopy again, the state of the uterine cavity was checked and the response to the treatment was compared in terms of the return of adhesions and its severity in the two groups.The significance level of the results was considered p>0.05.

In this research, 30 women were compared. 20 people were in the 2.5 mg group and 10 people were in the 5 mg estrogen group.The average age of the patients was 33.40 years. The most common cause of Asherman in the 2.5 mg group was curettage (60%), and in the 5 mg group, other surgical procedures (60%).. The two groups did not have statistically significant differences in terms of confounding variables including age,

. In the examination of treatment response, there was no statistically significant difference between the two groups in terms of adhesion severity in repeated hysteroscopy (P=0.858) and response to treatment (P=0.714).

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 06 April 2024

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