Document Type : Review Article
Authors
1
Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3
Department of Physiology, Faculty of Medicine Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
4
Department of Biostatistics and Epidemiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
6
Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
7
Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
10.22038/ijogi.2024.70879.5639
Abstract
Background: Changes in the activity of the gene encoding internal rectifier potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11), due to its polymorphisms have far-reaching effects on the metabolic processes of people with gestational diabetes mellitus (GDM). This systematic review and meta-analysis was conducted to further evaluate the association between the KCNJ11 (rs5219) polymorphism and GDM.
Materials and Methods: In this systematic review and meta-analysis, a literature search was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and some Persian-language databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association between KCNJ11 (rs5219) polymorphisms and susceptibility to GDM in four genetic models.
Results: A total of 5578 participants from six articles were included in the meta-analysis. We identified a significant relationship between the KCNJ11 (rs5219) gene polymorphism and GDM in the study population through an additive genetic model (OR = 1/14; 95%CI: 1.00–1/30; P = 0/049) and a recessive genetic model (OR = 0/86; 95% CI: 0/75–0/98; P = 0/033). On the contrary, there is no significant association between the KCNJ11 (rs5219) gene polymorphism and GDM in an allelic genetic model (OR = 1/25; 95%CI: 0/93–1/69; P = 0/136) and the dominant genetic model (OR = 1/15; 95% CI: 0/94–1/41; P = 0/157).
Conclusion: The results indicated that KCNJ11 gene polymorphism (rs5219) is associated with susceptibility to GDM in women. However, more studies on different ethnicities are required to confirm our results.
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