Dysgerminoma with Embryonal Carcinoma, a Rare Ovarian Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl: A Case Report

Document Type : Case report

Authors

1 Assistant Professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Resident, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Assistant Professor, Department of Obstetrics and Gynecology, Fellowship of Gynecologic Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/ijogi.2024.73625.5792

Abstract

Introduction: Pediatric patients rarely develop ovarian tumors, but mainly develop ovarian germ cell tumors. Malignant germ cell tumors are generally rare and dysgerminoma is the most frequent malignant ovarian neoplasm in young and adolescent girls. In this study, a case of ovarian malignant mixed germ cell tumor with combination of dysgerminoma and embryonal carcinoma component is reported.
Case presentation: A 13-year-old girl referred to Omid educational, research and treatment center of Mashhad with abdominal pain and swelling from five months ago and was gradually worsened. In the ultrasound examination, a mass with a cystic nature was reported in the pelvis with dimensions of 269×185mm. The patient underwent salpingo-oophorectomy surgery and tumor removal for pathological study. In the microscopic examination, 95% of malignant germ cell tumor was reported as dysgerminoma and 5% as embryonal carcinoma (CD 30 positive). The patient was discharged in good general condition to continue the treatment and receive chemotherapy.
Conclusion: Any adolescent girl who develops a rapidly growing pelvic mass should be evaluated for malignant mixed germ cell tumors of the ovary, which are highly aggressive. In these patients, prompt surgical intervention with fertility preservation is crucial.

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References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 26, Issue 11
January 2024
Pages 87-92

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