The effect of vitamin D on the assisted reproductive techniques (ART) outcomes: A narrative review

Document Type : Review Article

Authors

1 Associate Professor, Department of Midwifery and Reproductive Health, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

2 PhD student of Reproductive Health, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Introduction: Infertility is a global health concern and the prevalence of vitamin D deficiency in the infertile population is 27% to 65%. The role of vitamin D is proposed with the expression of receptors in all types of human reproductive tissues in reproductive health and the outcomes of ART. The present study was performed with aim to investigate the effect of vitamin D on ART outcomes.
Methods: In this review study, a comprehensive search was conducted in all databases of Web of Science, Scopus, Proquest, Pubmed, SID, Magiran and Google Scholar were conducted from 2015 to 2023 with English keywords of Assisted Reproductive Techniques, Vitamin D, Infertility, Male infertility, Female infertility and their Persian equivalents.
Results: In total, 15 qualified articles were selected from among 1014 articles found for this study. Based on a wide range of studies, vitamin D potentially plays an important role in human fertility, and a positive correlation between high concentration of vitamin D and clinical pregnancy rate, fetal quality, and live birth rate in ART was reported.
Conclusion: The effects of vitamin D on ART outcomes are controversial and its deficiency is related to ART outcomes. Probably, the effect of vitamin D deficiency on fertility is not associated with all forms of infertility and the difference in dose, time of supply and type of vitamin D may play a role in the contradiction of the results. Identifying the role of vitamin D in the pathogenesis of infertility and ART outcomes still requires further studies.

Keywords

Main Subjects

References

  1. Silvestris E, Lovero D, Palmirotta R. Nutrition and female fertility: an interdependent correlation. Frontiers in endocrinology 2019: 346.
  2. Kohil A, Chouliaras S, Alabduljabbar S, Lakshmanan AP, Ahmed SH, Awwad J, et al. Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review. Frontiers in Nutrition 2022; 9:927972.
  3. Berek JS. Berek & Novak's gynecology. Lippincott Williams & Wilkins; 2019.
  4. Chu J, Gallos I, Tobias A, Tan B, Eapen A, Coomarasamy A. Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis. Human reproduction 2018; 33(1):65-80.
  5. Gaskins AJ, Chavarro JE. Diet and fertility: a review. American journal of obstetrics and gynecology 2018; 218(4):379-89.
  6. Gaskins AJ, Nassan FL, Chiu YH, Arvizu M, Williams PL, Keller MG, et al. Dietary patterns and outcomes of assisted reproduction. American journal of obstetrics and gynecology 2019; 220(6):567-e1.
  7. Zhou X, Wu X, Luo X, Shao J, Guo D, Deng B, et al. Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials. Frontiers in Endocrinology 2022; 13:852428.
  8. Savabi EM, Heidari SM, Mokhtari F. Puberty process in children born from Assisted Reproductive Technologies: a review study. The Iranian Journal of Obstetrics, Gynecology and Infertility 2023; 26(2):84-98.
  9. Panth N, Gavarkovs A, Tamez M, Mattei J. The influence of diet on fertility and the implications for public health nutrition in the United States. Frontiers in public health 2018; 6:211.
  10. Jahangirifar M, Taebi M, Nasr-Esfahani MH, Askari G. Dietary patterns and the outcomes of assisted reproductive techniques in women with primary infertility: a prospective cohort study. International journal of fertility & sterility 2019; 12(4):316.
  11. Akbaribazm M, Goodarzi N, Rahimi M. Female infertility and herbal medicine: An overview of the new findings. Food science & nutrition 2021; 9(10):5869-82.
  12. Ko JK, Shi J, Li RH, Yeung WS, Ng EH. 100 YEARS OF VITAMIN D: Effect of serum vitamin D level before ovarian stimulation on the cumulative live birth rate of women undergoing in vitro fertilization: a retrospective analysis. Endocrine Connections 2022; 11(2).
  13. Chen Y, Liu D, Zeng L, Xu H, Jiang H, Yang R, et al. Effect of serum 25‐hydroxyvitamin D levels on sperm quality and assisted reproductive technology outcomes for men of infertile Chinese couples. Andrology 2020; 8(5):1277-86.
  14. Paffoni A, Somigliana E, Sarais V, Ferrari S, Reschini M, Makieva S, et al. Effect of vitamin D supplementation on assisted reproduction technology (ART) outcomes and underlying biological mechanisms: protocol of a randomized clinical controlled trial. The “supplementation of vitamin D and reproductive outcome”(SUNDRO) study. BMC Pregnancy and Childbirth 2019; 19(1):1-9.
  15. Chen Y, Zhi X. Roles of vitamin D in reproductive systems and assisted reproductive technology. Endocrinology 2020; 161(4):bqaa023.
  16. Inal ZO, Inal HA, Gorkem U. Sexual function and depressive symptoms in primary infertile women with vitamin D deficiency undergoing IVF treatment. Taiwanese Journal of Obstetrics and Gynecology 2020; 59(1):91-8.
  17. Rasekhjahromi A, Ahmadi F, Alborzi M, Kalani N. Association of Vitamin D3 and Laboratory Factors with Early Menopause: A Case-Control Study. Journal of Medicinal and Chemical Sciences 2022; 5(6):980-987.
  18. Hosseinisadat R, Saeed L, Ghasemirad A, Habibzadeh V, Heidari SS. Assessment of the effect of serum and follicular fluid vitamin D and glucose on assisted reproductive technique outcome: A cross-sectional study. International Journal of Reproductive BioMedicine 2022; 20(3):221.
  19. Boisen IM, Hansen LB, Mortensen LJ, Lanske B, Juul A, Jensen MB. Possible influence of vitamin D on male reproduction. The Journal of steroid biochemistry and molecular biology 2017; 173:215-22.
  20. Aoun A, El Khoury V, Malakieh R. Can Nutrition Help in the Treatment of Infertility?. Preventive nutrition and food science 2021; 26(2):109-20.
  21. Liu X, Zhang W, Xu Y, Chu Y, Wang X, Li Q, et al. Effect of vitamin D status on normal fertilization rate following in vitro fertilization. Reproductive Biology and Endocrinology 2019; 17(1):1-10.
  22. Moan J, Porojnicu AC, Dahlback A, Setlow RB. Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure. Proceedings of the National Academy of Sciences 2008; 105(2):668-73.
  23. Jiang L, Ji L, Song J, Qian K. The effect of serum vitamin D levels in couples on embryo development and clinical outcomes. Reproductive Biomedicine Online 2019; 38(5):699-710.
  24. Rasekhjahromi A, Paymard Z, Kalani N. The relationship between serum vitamin D levels and gestational diabetes: A case-control study. The Iranian Journal of Obstetrics Gynecology and Infertility 2022; 25(8):33-41.
  25. Walz NL, Hinchliffe PM, Soares MJ, Dhaliwal SS, Newsholme P, Yovich JL, et al. Serum Vitamin D status is associated with increased blastocyst development rate in women undergoing IVF. Reproductive BioMedicine Online 2020; 41(6):1101-11.
  26. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertility and sterility 2010; 94(4):1314-9.
  27. Neysanian G, Taebi M, Rezaeian A, Nasr-Esfahani MH, Jahangirifar M. The effects of serum and follicular fluid vitamin D levels on assisted reproductive techniques: a prospective cohort study. International Journal of Fertility & Sterility 2021; 15(4):280.
  28. Bosdou JK, Konstantinidou E, Anagnostis P, Kolibianakis EM, Goulis DG. Vitamin D and obesity: two interacting players in the field of infertility. Nutrients 2019; 11(7):1455.
  29. Voulgaris N, Papanastasiou L, Piaditis G, Angelousi A, Kaltsas G, Mastorakos G, et al. Vitamin D and aspects of female fertility. Hormones 2017; 16(1):5-21.
  30. Sorbi MH, Issazadegan A, Soleimani E, Mirhosseini H. Prevalence of restless legs syndrome in Iran: A systematic review and meta-analysis. Journal of Community Health Research 2020.
  31. Shakeri M, Taghipour A, Mazinani MS, Emamverdi Z, Hadianfar A, Yousefi R. Assessment of Randomized Clinical Trials articles in Medical Journal of Mashhad University of Medical Sciences based on CONSORT statement. medical journal of mashhad university of medical sciences 2021; 64(3).
  32. Farzadi L, Bidgoli HK, Ghojazadeh M, Bahrami Z, Fattahi A, Latifi Z, et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iranian journal of reproductive medicine 2015; 13(6):361.
  33. Abedi S, Taebi M, Esfahani MH. Effect of vitamin D supplementation on intracytoplasmic sperm injection outcomes: a randomized double-blind placebo-controlled trial. International Journal of Fertility & Sterility 2019; 13(1):18.
  34. Somigliana E, Sarais V, Reschini M, Ferrari S, Makieva S, Cermisoni GC, et al. Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial. American Journal of Obstetrics and Gynecology 2021; 225(3):283-e1.
  35. Doryanizadeh L, Morshed-Behbahani B, Parsanezhad ME, Dabbaghmanesh MH, Jokar A. Calcitriol effect on outcomes of in vitro fertilization in infertile women with vitamin D deficiency: a double-blind randomized clinical trial. Zeitschrift für Geburtshilfe und Neonatologie 2021; 225(03):226-31.
  36. Chu J, Gallos I, Tobias A, Robinson L, Kirkman-Brown J, Dhillon-Smith R, et al. Vitamin D and assisted reproductive treatment outcome: a prospective cohort study. Reproductive health 2019; 16(1):1-10.
  37. Banker M, Sorathiya D, Shah S. Vitamin D deficiency does not influence reproductive outcomes of IVF-ICSI: a study of oocyte donors and recipients. Journal of Human Reproductive Sciences 2017; 10(2):79.
  38. Zair AB, Dolu N, Danfour M. The Correlation between Serum Vitamin D and Oocyte Quality, Potential of Fertilization and Embryo Development in the Assisted Reproductive Technology (ART) Cases. Journal of Global Scientific Research 2022; 7(6):2406-14.
  39. Blomberg Jensen M, Lawaetz JG, Petersen JH, Juul A, Jørgensen N. Effects of vitamin D supplementation on semen quality, reproductive hormones, and live birth rate: a randomized clinical trial. The Journal of Clinical Endocrinology & Metabolism 2018; 103(3):870-81.
  40. Liao EY, Zhang ZL, Xia WB, Lin H, Cheng Q, Wang L, et al. Calcifediol (25-hydroxyvitamin D) improvement and calcium-phosphate metabolism of alendronate sodium/vitamin D3 combination in Chinese women with postmenopausal osteoporosis: a post hoc efficacy analysis and safety reappraisal. BMC Musculoskeletal Disorders 2018; 19(1):1-8.
  41. Harkness LS, Bonny AE. Calcium and vitamin D status in the adolescent: key roles for bone, body weight, glucose tolerance, and estrogen biosynthesis. Journal of pediatric and adolescent gynecology 2005; 18(5):305-11.
  42. Zhao J, Liu S, Wang Y, Wang P, Qu D, Liu M, et al. Vitamin D improves in-vitro fertilization outcomes in infertile women with polycystic ovary syndrome and insulin resistance. Minerva Medica 2019; 110(3):199-208.
  43. Heidary M, Yazdanpanahi Z, Dabbaghmanesh MH, Parsanezhad ME, Emamghoreishi M, Akbarzadeh M. Effect of chamomile capsule on lipid-and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 2018; 23.
  44. Grzechocinska B, Dabrowski FA, Cyganek A, Wielgos M. The role of vitamin D in impaired fertility treatment. Neuroendocrinol Lett 2013; 34(8):756-62.
  45. Franasiak JM, Molinaro TA, Dubell EK, Scott KL, Ruiz AR, Forman EJ, et al. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. American journal of obstetrics and gynecology 2015; 212(3):315-e1.
  46. Várbíró S, Takács I, Tűű L, Nas K, Sziva RE, Hetthéssy JR, et al. Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review. Nutrients 2022; 14(8):1649.
  47. Gorelova IV, Popova PV, Rulev MV. Vitamin D and reproductive health. Problemy Endokrinologii 2020; 66(5):96-101.
  48. Bezerra Espinola MS, Bilotta G, Aragona C. Positive effect of a new supplementation of vitamin D3 with myo-inositol, folic acid and melatonin on IVF outcomes: a prospective randomized and controlled pilot study. Gynecological Endocrinology 2021; 37(3):251-4.
  49. Aflatoonian A, Arabjahvani F, Eftekhar M, Sayadi M. Effect of vitamin D insufficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles: A randomized clinical trial. Iranian journal of reproductive medicine 2014; 12(9):595.
  50. Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of vitamin D levels on IVF outcomes. Human reproduction 2012; 27(11):3321-7.
  51. Pacis MM, Fortin CN, Zarek SM, Mumford SL, Segars JH. Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review. Journal of assisted reproduction and genetics 2015; 32:323-35.
  52. Vigano P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. Journal of Molecular Endocrinology 2006; 36(3):415-24.
  53. Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA. Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients. Fertility and sterility 2014; 102(6):1608-12.
  54. Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertility and sterility 2014; 101(2):447-52.
  55. Cito G, Cocci A, Micelli E, Gabutti A, Russo GI, Coccia ME, et al. Vitamin D and male fertility: an updated review. The world journal of men's health 2020; 38(2):164.
  56. Abbasihormozi SH, Kouhkan A, Alizadeh AR, Shahverdi AH, Nasr‐Esfahani MH, Sadighi Gilani MA, et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology 2017; 5(1):113-8.
  57. Yang B, Sun H, Wan Y, Wang H, Qin W, Yang L, et al. Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. International journal of andrology 2012; 35(6):783-92.
  58. de Angelis C, Galdiero M, Pivonello C, Garifalos F, Menafra D, Cariati F, et al. The role of vitamin D in male fertility: A focus on the testis. Reviews in Endocrine and Metabolic Disorders 2017; 18:285-305.
  59. Blomberg Jensen M, Gerner Lawaetz J, Andersson AM, Petersen JH, Nordkap L, Bang AK, et al. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Human reproduction 2016; 31(8):1875-85.
  60. Blomberg Jensen M, Jørgensen A, Nielsen JE, Bjerrum PJ, Skalkam M, et al. Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. International journal of andrology 2012; 35(4):499-510.
  61. Blomberg Jensen M, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human reproduction 2011; 26(6):1307-17.
  62. Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M, Carrell DT. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian journal of andrology 2012; 14(6):855.
  63. Tartagni M, Matteo M, Baldini D, Tartagni MV, Alrasheed H, De Salvia MA, et al. Males with low serum levels of vitamin D have lower pregnancy rates when ovulation induction and timed intercourse are used as a treatment for infertile couples: results from a pilot study. Reproductive Biology and Endocrinology 2015; 13(1):1-7.
  64. Jensen MB. Vitamin D and male reproduction. Nature Reviews Endocrinology 2014; 10(3):175-86.
  65. Bøllehuus Hansen L, Rehfeld A, de Neergaard R, Nielsen JE, Iversen LH, Boisen IM, et al. Selection of high-quality spermatozoa may be promoted by activated vitamin D in the woman. The Journal of Clinical Endocrinology & Metabolism 2017; 102(3):950-61.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 26, Issue 12
February 2024
Pages 50-65

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