The effect of vitamin B6 on the breast pain in first trimester of pregnancy in pregnant women referring to the comprehensive health centers in Gonabad, 2019-2020

Document Type : Original Article

Authors

1 M.Sc. student of Midwifery, Student Working Group of Reproductive Health and Population Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

2 Associate professor, Department of Midwifery, Reproductive Health and Population Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

3 Associate professor, Department of Midwifery, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Associate Professor, Department of Nutrition Sciences and Biochemistry, Reproductive Health and Population Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Abstract

Introduction: The first trimester of pregnancy is associated with unpleasant experiences for mothers. One of these unpleasant experiences is breast pain, which leads to a low quality of life in pregnant women, so the present study was conducted with aim to investigate the effect of vitamin B6 as a safe and available supplement on breast pain in the first trimester of pregnancy.
Methods: This randomized controlled clinical trial study was conducted in 2019-2020 on women with a gestational age of 6-10 weeks who had breast pain with start of pregnancy for 5 days or more in Gonabad city. Pregnant women were divided into two groups of 42 people, control and intervention. The control group was given a placebo daily and the intervention group was given a 40 mg vitamin B6 pill for 1 month. The visual pain scale questionnaire was given to the research units before and one month after the intervention. The amounts of vitamin B6 received from the diet of the groups were obtained through a 24-hour food reminder questionnaire and N4 software. Data analysis was done using SPSS software (version 20) and independent t-tests, Mann-Whitney, Chi-square, Fisher, Wilcoxon and regression. P<0.05 was considered significant.
Results: There was a statistically significant difference between the two groups regarding the gestational age (p=0.04), but other pregnancy variables were homogeneous in the two groups (p>0.05). According to Mann-Whitney test results, there was no significant difference between the two groups regarding the mean score of breast pain after the intervention (p=0.2).
Conclusion: The effect of oral vitamin B6 compared to placebo is not effective on reducing breast pain score in the first trimester of pregnancy. Further studies with a larger sample size, different doses of vitamin B6 and measuring the serum level of vitamin B6 are suggested.

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  1. Azami M, Darvishi Z, Borji M, Sayehmiri K. The prevalence of anemia among pregnant women in Iran (2005-2016); a systematic review and meta-analysis study. Journal of School of Public Health & Institute of Public Health Research 2016; 14(1).
  2. Mallah FA, Tabrizian-Namin S, Eslamnezhad K, Darghahi R. Prevalence and Factors Affecting Pregnancy Depression: A Systematic Review. Journal of Clinical Nursing and Midwifery 2021; 9(4):832-9.
  3. Sharifirad GR, Tol A, Mohebi S, Matlabi M, Shahnazi H, Shahsiah M. The effectiveness of nutrition education program based on health belief model compared with traditional training. J Educ Health Promot 2013; 2:15.
  4. Dadgar S, Abdollahi M, Anbaran K. The relationship between minor ailments of pregnancy and quality of life in pregnant women. the iranian journal of obstetrics gynecology and infertility 2017; 20(6):8-21.
  5. Hafiz SP, Barnes NL, Kirwan CC. Clinical management of idiopathic mastalgia: a systematic review. Journal of primary health care 2018; 10(4):312-23.
  6. Sheidaei S, Irani M, Ghazanfarpour M. The effect of Herbal Medicines and Supplements on Mastalgia: A systematic review and meta-analysis of clinical trials in Iran. The Iranian Journal of Obstetrics, Gynecology and Infertility 2019; 22(3):87-98.
  7. Ministry of Health and Medical Education PHO. Integrated maternal health care. Esfahan: Padideye Goya; 2016. p. 30.
  8. Soltany S, Toussy JA, Hemmati HA, Gholamaliyan E. Effect of vitamin B6 on mastalgia: a double blind clinical trial. Koomesh 2016; 17(4).
  9. Bilandi RR, Salar A. Vitamin B6 Effects on Breast Pain in Women of Reproductive Age: A Systematic Review. Zahedan Journal of Research in Medical Sciences 2021; 23(2).
  10. Zhao LG, Shu XO, Li HL, Gao J, Han LH, Wang J, et al. Prospective cohort studies of dietary vitamin B6 intake and risk of cause-specific mortality. Clinical Nutrition 2019; 38(3):1180-7.
  11. Zhao M, Lamers Y, Ralat MA, Coats BS, Chi YY, Muller KE, et al. Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. The Journal of nutrition 2012; 142(10):1791-7.
  12. Stach K, Stach W, Augoff K. Vitamin B6 in health and disease. Nutrients 2021; 13(9):3229.
  13. Kumrungsee T, Zhang P, Chartkul M, Yanaka N, Kato N. Potential role of vitamin B6 in ameliorating the severity of COVID-19 and its complications. Frontiers in nutrition 2020: 220.
  14. Bunga EJ, Lukas E, Tumedia JL, Chalid SM. The Effect of Pyridoxine on Prostaglandin Plasma Level in Patients with Primary Dysmenorrhea. Indones J Obstet Gynecol 2018; 6(4):239-42.
  15. Ahn S, Kim J, Cho J. Effects of breast massage on breast pain, breast-milk sodium, and newborn suckling in early postpartum mothers. Journal of Korean Academy of Nursing 2011; 41(4):451-9.
  16. Jahdi F, Tolouei R, Samani LN, Hashemian M, Haghani H, Mojab F, et al. Effect of evening primrose oil and vitamin b6 on pain control of cyclic mastalgia associated with fibrocystic breast changes: a triple-blind randomized controlled trial. Shiraz E-Medical Journal 2019; 20(5).
  17. Salehian T, Tadayon M, Delaram M, Abbaspour Z. The comparison of the acupressure and pyridoxine effect on severity of both nausea and vomiting in primigravida women. J Shahrekord Univ Med Sci 2005; 7(3):55-60.
  18. Shobeiri F, Oshvandi K, Nazari M. Clinical effectiveness of vitamin E and vitamin B6 for improving pain severity in cyclic mastalgia. Iranian journal of nursing and midwifery research 2015; 20(6):723-7.
  19. Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. Journal of clinical nursing 2005; 14(7):798-804.
  20. Genc V, Genc A, Ustuner E, Dusunceli EB, Oztuna D, Bayar S, et al. Is there an association between mastalgia and fibromyalgia? Comparing prevalence and symptom severity. The Breast 2011; 20(4):314-8.
  21. Firouzbakht M, Nikpour M, Omidvar S, Kiapour A. Comparative Study of Effects of Ginger with Vit. B6 in Treatment Nausea and Vomiting During Pregnancy. Family Health Quarterly 2013; 1(3):8-13
  22. Khodadad M, Kheirabadi G, Bahadoran P. Efficacy of vitamin B6 on pregnancy outcomes: A randomized clinical trial. Journal of Pharmaceutical Research International 2017; 19(1):1-9.
  23. Faramarzi M, Yazdani S, Barat S. A RCT of psychotherapy in women with nausea and vomiting of pregnancy. Human Reproduction 2015; 30(12):2764-73.
  24. Cuschieri S. The CONSORT statement. Saudi journal of anaesthesia 2019; 13(Suppl 1):S27.
  25. Stover PJ, Field MS. Vitamin B-6. Advances in Nutrition 2015; 6(1):132-3.
  26. Stach K, Stach W, Augoff K. Vitamin B6 in health and disease. Nutrients 2021; 13(9):3229.
  27. Sayehmiri K, Asadi-Samani M, Bahmani M. Effects of vitamin B6 on premenstrual syndrome: A systematic review and meta-analysis. Journal of Chemical and Pharmaceutical Science 2016; 9(3):1346-53.
  28. Gumm R, Cunnick GH, Mokbel K. Evidence for the management of mastalgia. Current medical research and opinion 2004; 20(5):681-4.
  29. Koleini S, Valiani M. Comparing the effect of auriculotherapy and vitamin B6 on the symptoms of premenstrual syndrome among the students who lived in the dorm of Isfahan University of Medical Sciences. Iranian journal of nursing and midwifery research 2017; 22(5):354.
  30. Soltany S, Alavy Toussy J. The effect of vitamin B6 on cyclic and non-cyclic mastalgia. Advances in Environmental Biology 2014: 2936-9.
  31. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse D, Spong CY, et al. Williams Obstetrics. 23nd New York: McGraw-Hill Education; 2011.
  32. American Pregnancy Association. org/ American2020-04-27 [updated "2023-09-20، T:11:47; cited 2023 13.08.2023]. Available from: https://americanpregnancy.org/healthy-pregnancy/changes-in-your-body/breast-changes-during-pregnancy/.
  33. Yikar SK, Nazik E. Effects of prenatal education on complaints during pregnancy and on quality of life. Patient education and counseling 2019; 102(1):119-25.
  34. Kooshki A, Yaghoubi MA, Rahsepar FR. Comparison of energy and nutrient intakes in pregnant women in Sabzevar with dietary reference intakes. Iranian journal of obstetrics, gynecology and infertility 2009; 12(1):49-53.
  35. Manafi Majid, Rabieipour S, Pourheidar B. Investigating the amount of food consumption in pregnant women referring to health centers in Urmia city. the journal of Urmia University of Medical Sciences 2003; 14(4):9-15.
  36. Osman AR, Salah Shalaby N, El-Shabory ME, El-Hoda N, Abdel–Fatah Mohamed Shehata A. Daily Dietary habits and Nutrition Attitude of Pregnant Women in Port-said city. Egyptian Journal of Health Care 2022; 13(4):13-25.