The Comparison of Maternal and Fetal Insulin, C Peptide and Insulin-Like Growth Factor 1 Concentration in Healthy and Pregnant Women with Gestational Diabetes and Their Correlation with Neonatal Birth Weight

Document Type : Original Article

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, High Risk Pregnancy Research Center, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

2 Professor, Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

3 Resident, Department of Obstetrics and Gynecology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

Introduction: The insulin levels, insulin-like growth factors and C-peptide have effects on the progression of fetal growth. There are controversial results about the effects of these parameters on fetal growth. This study for the first time had investigated the serum levels of IGF-1, insulin and C-peptide simultaneously both in mothers with gestational diabetes and in their infants compared to healthy pregnant women and has determined their conflation with infant's weight.
Methods: This analytical cross sectional study was conducted on 85 healthy and diabetic pregnant women hospitalized in Imam Reza hospital of Kermanshah, Iran in 2010-2011 at the time of delivery. Fasting blood samples were obtained from mothers and cord venous blood samples were obtained immediately after birth. The serum levels of IGF-1, insulin and C-peptide were determined by ELISA method. Data were analyzed using SPSS software version 16, independent t-test, Mann-Whitney u and Pearson correlation coefficient tests. P value less than 0.05 was considered significant.
Results: The serum levels of IGF-1 in diabetic mothers and in their infants was significantly correlated with infants birth weight (p=0.043, p=0.028). But other measured parameters in healthy and diabetic mothers were not significantly associated with birth weight.
Conclusion: Serum level of IGF-1 in mothers with gestational diabetes and in their newborn is correlated to infant's birth weight.

Keywords

References

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