The consumption of phytoestrogen containing foods in postmenopausal women and its relationship with menopause symptoms in Jahrom, Iran, 2022

Document Type : Original Article

Authors

1 M.Sc. student of Geriatric Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Assistant Professor, Department of Health Promotion, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Assistant Professor, Department of Nutritional Sciences , Research Center for Traditional Medicine and history of Medicine, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

4 Associate Professor, Department of Health Promotion, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

5 M.Sc. of Medical-Surgical Nursing, School of Nursing, Jahrom University of Medical Sciences, Jahrom, Iran.

Abstract

Introduction: Phytoestrogen containing foods are known useful in controlling menopause symptom. Researches revealed that these foods can be useful for the health of menopausal women. Considering the importance of non-pharmacological treatments in reducing menopausal symptoms and confirming the effectiveness of phytoestrogen consumption in reducing these symptoms, this study was conducted to investigate the amount of phytoestrogen consumption and its relationship with menopausal symptoms.
Methods: This cross-sectional study was performed in 2022 on 130 middle-aged (45 to 55 years old) women living in Jahrom, Iran. Tools used in this study included a demographic questionnaire, a menopause rating scale, knowledge and attitude regarding phytoestrogen-containing foods and a 3-day food record questionnaire. Data were analyzed using SPSS software (version 24) and Pearson correlation coefficient. P<0.05 was considered statistically significant.
Results: The mean amount of phytoestrogen consumed daily by the participants was 72.92±33.36 mg. Pearson correlation analyses indicated that the total amount of phytoestrogens consumed had an inverse and significant correlation with the psychological symptoms of menopause (p=.01, r=-0.190), but no significant relationship was found with the physical, urogenital, and total symptoms of menopause with amount of phytoestrogens consumed (p=0.11).
Conclusion: The consumption of phytoestrogens to some extent leads to a reduction of mental symptoms in menopausal women, but they have no effect on physical symptoms.

Keywords


  1. Shakiba M, Rouhbakhsh M, Kermansaravi F, Navidian A. The effect of couple counseling on severity of menopausal symptoms in women. HAYAT 2019; 25(1):25-38.
  2. Moghadam R, Ozgoli G, Molayi B, Majid H, Soori H, Ghanati K. Effect of omega3 on vasomotor disorders in menopausal women. Journal of Arak University of Medical Sciences 2012; 15(1):116-26.
  3. Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Human reproduction 1992; 7(10):1342-6.
  4. Minkin MJ, Reiter S, Maamari R. Prevalence of postmenopausal symptoms in North America and Europe. Menopause 2015; 22(11):1231-8.
  5. Labrie F, Martel C, Pelletier G. Is vulvovaginal atrophy due to a lack of both estrogens and androgens?. Menopause 2017; 24(4):452-61.
  6. Delamater L, Santoro N. Management of the perimenopause. Clinical obstetrics and gynecology 2018; 61(3):419.
  7. Palma F, Xholli A, Cagnacci A. The most bothersome symptom of vaginal atrophy: Evidence from the observational AGATA study. Maturitas 2018; 108:18-23.
  8. Bahri N, Yoshany N, Morowatisharifabad MA, Noghabi AD, Sajjadi M. The effects of menopausal health training for spouses on women's quality of life during menopause transitional period. Menopause 2016; 23(2):183-8.
  9. Santoro N. Perimenopause: From Research to Practice. J Womens Health (Larchmt) 2016; 25(4):332-9.
  10. Abernethy K. Managing short-term menopausal symptoms (Section 8). Post Reproductive Health 2016; 22(2):63-6.
  11. Aemi SZ, Dadgar S, Pourtaghi F, Hoseini ZA, Moghadam ZE. The effect of exercise program using elastic band in improving the old women's health. Iran J Obstet Gynecol Infertil 2016; 18(177):20-5.
  12. Abbaspour Z, Mohammadi Nik F, Zand Moghadam A, Saadati N, Latifi S. A study on effect of isolated soy on hot flushes of menopausal women. Sci Med J 2003; 36:18-25.
  13. Barnabei VM, Cochrane BB, Aragaki AK, Nygaard I, Williams RS, McGovern PG, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative. Obstetrics & Gynecology 2005; 105(5 Part 1):1063-73.
  14. Forouhari S, Safarirad M, Moatari M, Mohit M, Ghaem H. The effect of education on quality of life in menopausal women referring to Shiraz Motahhari clinic in 2004. Journal of Birjand University of Medical Sciences 2009; 16(1):39-44.
  15. Dizavandi FR, Ghazanfarpour M, Roozbeh N, Kargarfard L, Khadivzadeh T, Dashti S. An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri-and post-menopausal women. Post Reproductive Health 2019; 25(1):11-20.
  16. Caruso S, Cianci S, Fava V, Rapisarda A, Cutello S, Cianci A. Vaginal health of postmenopausal women on nutraceutical containing equol. Menopause 2018; 25(4):430-5.
  17. Hasler CM. Functional foods: their role in disease prevention and health promotion. Food Technology-Champaign then Chicago 1998; 52:63-147.
  18. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. The scientific world journal 2013; 2013.
  19. Wroblewski Lissin L, Cooke JP. Phytoestrogens and cardiovascular health. Journal of the American College of Cardiology 2000; 35(6):1403-10.
  20. Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicology in vitro 2006; 20(2):187-210.
  21. Taavoni S, Shakeri F, Haghani H. Effect of red clover on vasomotor symptoms and heart discomfort of menopausal women. Complementary Medicine Journal 2012; 2(3):235-45.
  22. Jefferson WN, Patisaul HB, Williams CJ. Reproductive consequences of developmental phytoestrogen exposure. Reproduction (Cambridge, England) 2012; 143(3):247.
  23. Knight DC, Eden JA. Phytoestrogens—a short review. Maturitas 1995; 22(3):167-75.
  24. Chiechi LM. Dietary phytoestrogens in the prevention of long-term postmenopausal diseases. International Journal of Gynecology & Obstetrics 1999; 67(1):39-40.
  25. Lof M, Weiderpass E. Epidemiologic evidence suggests that dietary phytoestrogen intake is associated with reduced risk of breast, endometrial, and prostate cancers. Nutrition Research 2006; 26(12):609-19.
  26. Jefferson WN, Padilla-Banks E, Newbold RR. Disruption of the female reproductive system by the phytoestrogen genistein. Reproductive Toxicology 2007; 23(3):308-16.
  27. Davis SR. Phytoestrogen therapy for menopausal symptoms?: There's no good evidence that it's any better than placebo. BMJ 2001; 323(7309):354-5.
  28. Welty FK, Lee KS, Lew NS, Nasca MM, Zhou JR. The association between soy nut consumption and decreased menopausal symptoms. Journal of women's health 2007; 16(3):361-9.
  29. Reed SD, Lampe JW, Qu C, Gundersen G, Fuller S, Copeland WK, et al. Self-reported menopausal symptoms in a racially diverse population and soy food consumption. Maturitas 2013; 75(2):152-8.
  30. Glisic M, Kastrati N, Musa J, Milic J, Asllanaj E, Fernandez EP, et al. Phytoestrogen supplementation and body composition in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials. Maturitas 2018; 115:74-83.
  31. Fait T. Menopause hormone therapy: latest developments and clinical practice. Drugs in context 2019; 8.
  32. Camplese L, Hamza T. Phytoestrogens in Breast Cancer. Worcester Polytechnic Institute. Retrieved February 2020; 27:2022.
  33. Golyan Tehrani S, Ghobadzadeh M, Arastou M. Promoting health status of menopausal women by educating self care strategies. Hayat Journal 2007; 13(3):67-75.
  34. Del Sueldo M, Martell-Claros N, Abad-Cardiel M, Zilberman JM, Marchegiani R, Fernández-Pérez C. Health perception in menopausal women. International journal of women's health 2018; 10:655.
  35. Pond M. When the Menopause Carnival Comes to Town. InMenopause. Penn State University Press 2021: 96-111.
  36. Heinemann K, Ruebig A, Potthoff P, Schneider HP, Strelow F, Heinemann LA, Do MT. The Menopause Rating Scale (MRS) scale: a methodological review. Health Qual Life Outcomes. 2004 Sep 2;2:45. doi: 10.1186/1477-7525-2-45. PMID: 15345062; PMCID: PMC516787.
  37. Allahverdipour H, Asghari Jafarabadi M, Burri A, Javadivala Z. The Persian Version of Menopause Rating Scale (MRS): A Psychometric Study. Int J Womens Health 2020; 12:505-512.
  38. Lawshe CH. A quantitative approach to content validity. Personnel psychology 1975; 28(4):563-75.
  39. Waltz CF, Bausell RB. Nursing research: design, statistics, and computer analysis.Illustrated ed. Philadelphia: F.A. Davis Co; 1981.
  40. Reinli K, Block G. Phytoestrogen content of foods—a compendium of literature values. Nutrition and cancer 1996; 26(2):123-48.
  41. Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998; 7(12):1101-8.
  42. Barnes S. Soy isoflavones—phytoestrogens and what else?. The Journal of nutrition 2004; 134(5):1225S-8S.
  43. Cederroth CR, Zimmermann C, Nef S. Soy, phytoestrogens and their impact on reproductive health. Molecular and cellular endocrinology 2012; 355(2):192-200.
  44. Mohammad K, Hashemi SM, Farahani FK. Age at natural menopause in Iran. Maturitas 2004; 49(4):321-6.
  45. Akbarian A, Mehdizadeh A, Bibiamin E, Malekafzali H. Age of onset of menopause and effective factors on it in the women of Reye town during the year 1371. KAUMS Journal (FEYZ) 1999; 3(3):46-52.
  46. Greer W, Sandridge AL, Chehabeddine RS. The frequency distribution of age at natural menopause among Saudi Arabian women. Maturitas 2003; 46(4):263-72.
  47. Özdemir O, Çöl M. The age at menopause and associated factors at the health center area in Ankara, Turkey. Maturitas 2004; 49(3):211-9.
  48. Blieszner PB. Promises and pitfalls of the interactive television approach to teaching adult development and aging. Educational Gerontology 1999; 25(8):741-53.
  49. Wylie-Rosett J. Menopause, micronutrients, and hormone therapy. The American journal of clinical nutrition 2005; 81(5):1223S-31S.
  50. Salehi K, Ehsanpour S, Zolfaghari B, Salehi Z, Honargoo M. Effect of red clover Isoflavones extract on menopausal symptoms. Journal of Gorgan University of Medical Sciences 2013; 15(2):21-8.
  51. Najar S, Yaralizadeh M, Abedi P, Namjooyan F. Effect of fennel vaginal cream on dysparonia and sexual satisfaction among postmenopausal women: a double-blind randomized controlled trial. Iran J Obstet Gynecol Infertil 2015; 18(171):8-16.
  52. Abdali K, Dowran P, Emamghoreishi M, Kasraian M, Tabatabaei H. Comparison of the effect of Foeniculum vulgare and St John’s wort (Hypericum perforatum) on the climacteric symptoms and sexual activity in menopausal woman. Int J Adv Biotechnol Res 2016; 7(7):148-54.
  53. Abdnezhad R, Simbar M. A review of the effective herbal medicines on hot flashes in menopausal women. Iran J Obstet Gynecol Infertil 2020; 23(8):107-19.
  54. Krebs EE, Ensrud KE, MacDonald R, Wilt TJ. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstetrics & Gynecology 2004; 104(4):824-36.