Serum sodium and potassium levels in mothers with term and preterm delivery: a case-control study

Document Type : Original Article

Authors

1 Instructor, Department of Midwifery, Gonabad Branch, Islamic Azad University, Gonabad, Iran.

2 Assistant Professor, Department of Reproductive Health, Social Development and Health Promotion Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

3 PhD of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

4 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Abstract

Introduction: Preterm labor is a common concern of the World Health Organization. Studies have shown that Potassium and sodium channels in the smooth muscles of the uterus are involved in causing uterine contractions. Therefore, this study was performed with aim to evaluate the serum levels of sodium and potassium in preterm labor.
Methods: This case-control study was performed on 86 pregnant women referred to Gonabad Allameh Behlool Hospital in 2019-2020 in two groups of preterm and term delivery. The two groups were matched in terms of body mass index in early pregnancy, number of pregnancies and deliveries, level of education, income, and employment status. Blood sample was taken from the mothers after obtaining the inclusion criteria at the time of admission in labor to assess serum sodium and potassium levels. Demographic and midwifery information were collected using a questionnaire and patient's file. Data were analyzed by SPSS statistical software (version 26), and Mann-Whitney, Chi-square and Fisher tests. P< 0.05 was considered statistically significant.
Results: The mean serum sodium level in the case group (123.98±21.11 mEq/L) was lower than the control group (131.43±11.39 mEq/L) and the mean serum potassium level in the case group (4.66±5.92 mEq/L) was more than the control group (3.82±0.34 mEq/L) but these differences were not statistically significant (p> 0.05).
Conclusion: There is no relationship between serum sodium and potassium levels with preterm delivery. To investigate the relationship between maternal serum sodium and potassium and preterm delivery, further research is needed to evaluate the intracellular level of sodium and potassium.

Keywords

References

  1. Fakheri T, Hemati M, Shah Hossaini E, Nankali A. Prevalence of Group B Streptococcus in pregnant women at 24-34 weeks of gestation, with symptoms of preterm labor with and without rupture of membrane. Iran J Obstet Gynecol Infertil 2020; 23(1):19-24.
  2. Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Practice & Research Clinical Obstetrics & Gynaecology 2018; 52:3-12.
  3. Varni H, Krips JM, Jejor KL. Varni obstetrics. Translated by: Taghizadeh Z, Granmayeh M, Rahimpoor F. 1nd Tehran: Andisheh Rafie publication 2008.
  4. Guvenal T, Kantas E, Erselcan T, Culhaoglu Y, Cetin A. Beta-human chorionic gonadotropin and prolactin assays in cervicovaginal secretions as a predictor of preterm delivery. Int J Obstet Gynecol 2001; 75(3):229-34.
  5. Suff N, Story L, Shennan A. The prediction of preterm delivery: What is new?. InSeminars in Fetal and Neonatal Medicine 2019; 24(1):27-32.
  6. Purisch SE, Gyamfi-Bannerman C. Epidemiology of preterm birth. InSeminars in perinatology 2017; 41(7):387-91.
  7. Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bulletin of the World Health Organization 2010; 88:31-8.
  8. Vakilian K, Ranjbaran M, Khorsandi M, Sharafkhani N, Khodadost M. Prevalence of preterm labor in Iran: A systematic review and meta-analysis. Int J Reprod Biomed 2015; 13(12):743.
  9. Lasiuk GC, Comeau T, Newburn-Cook C. Unexpected: an interpretive description of parental traumas’ associated with preterm birth. BMC pregnancy and childbirth 2013; 13(1):S13.
  10. Gaucher N, Payot A. From powerlessness to empowerment: Mothers expect more than information from the prenatal consultation for preterm labour. Paediatrics & child health 2011; 16(10):638-42.
  11. Khakazan Z, Geranmayeh M, Taghizadeh G, Haghani H. The survey of association between occupational factors and preterm childbirth, HAYAT-J Fac Nurs Midwifery 2008; 13(4):5-14.
  12. Sotiriadis A, Papatheodorou S, Kavvadias A, Makrydimas G. Transvaginal cervical length measurement for prediction of preterm birth in women with threatened preterm labor: a meta‐ Ultrasound in Obstetrics and Gynecology: Ultrasound Obstet Gynecol 2010; 35(1):54-64.
  13. Haas DM, Imperiale TF, Kirkpatrick PR, Klein RW, Zollinger TW, Golichowski AM. Tocolytic therapy: a meta-analysis and decision analysis. Obstetrics & Gynecology 2009; 113(3):585-94.
  14. Chehreh R, Karamolahi Z, Aevazi A, Borji M, Saffar A. Prevalence of preterm birth recurrence and related factors in Ilam. Iran J Obstet Gynecol Infertil 2018; 21(10):20-9.
  15. Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. Williams Obstetrics. 25nd New York: McGraw-Hill Education; 2018.
  16. Meis PJ, Goldenberg RL, Mercer BM, Iams JD, Moawad AH, Miodovnik M, et al. The preterm prediction study: risk factors for indicated preterm births. Am J Obstet Gynecol 1998; 178(3):562-7.
  17. Passini Jr R, Cecatti JG, Lajos GJ, Tedesco RP, Nomura ML, Dias TZ, et al. Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth. PloS one 2014; 9(10):e109069.
  18. Buxton IL, Heyman N, Wu YY, Barnett S, Ulrich C. A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction. Acta Pharmacol Sin 2011; 32(6):758-64.
  19. Cheung KL, Lafayette RA. Renal physiology of pregnancy. Advances in chronic kidney disease 2013; 20(3):209-14.
  20. Williams SR. Basic nutrition and diet therapy. Basic nutrition and diet therapy 1995(Ed. 10).
  21. Van Leeuwen AM, Bladh ML. Davis's Comprehensive Manual of Laboratory and Diagnostic Tests with Nursing Implications. FA Davis; 2019.
  22. Lindheimer MD, Richardson DA, Ehrlich EN, Katz AI. Potassium homeostasis in pregnancy. The Journal of reproductive medicine 1987; 32(7):517-22.
  23. Wolak T, Sergienko R, Wiznitzer A, Ben Shlush L, Paran E, Sheiner E. Low potassium level during the first half of pregnancy is associated with lower risk for the development of gestational diabetes mellitus and severe pre-eclampsia. J Matern Fetal Neonatal Med 2010; 23(9):994-8.
  24. Wolak T, Shoham-Vardi I, Sergienko R, Sheiner E. High potassium level during pregnancy is associated with future cardiovascular morbidity. J Matern Fetal Neonatal Med 2016; 29(6):1021-4.
  25. Thorneloe KS, Nelson MT. Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Can J Physiol Pharmacol 2005; 83(3):215-42.
  26. Reinl EL, Zhao P, Wu W, Ma X, Amazu C, Bok R, et al. Na+-leak channel, non-selective (NALCN) regulates myometrial excitability and facilitates successful parturition. Cellular Physiology and Biochemistry 2018; 48(2):503-15.
  27. Khan RN, Matharoo-Ball B, Arulkumaran S, Ashford ML. Potassium channels in the human myometrium. Experimental physiology 2001; 86(2):255-64.
  28. Amazu C, Ferreira JJ, Santi CM, England SK. Sodium channels and transporters in the myometrium. Current Opinion in Physiology 2020; 13:141-4.
  29. Mitrovic-Jovanovic A, Dragojevic-Dikic S, Zamurovic M, Nikolic B, Gojnic M, Rakic S, et al. Comparison of electrolytic status (Na+, K+, Ca2+, Mg2+) in preterm and term deliveries. Clin Exp Obstet Gynecol 2012; 39(4):479-82.
  30. Maamouri G, Boskabadi H, Noria M, Ayatollahi H, Ghayour-Mobarhan M, Heshmati A, et al. Maternal and neonatal zinc and copper levels and birth
  31. Ellory JC, Flatman PW, Stewart GW. Inhibition of human red cell sodium and potassium transport by divalent cations. The Journal of physiology 1983; 340(1):1-17.
  32. Owusu Darkwa E, Djagbletey R, Antwi-Boasiako C, Aryee G, Sottie D, Akowuah A. Serum sodium and potassium levels in preeclampsia: a case-control study in a large tertiary hospital in Ghana. Cogent Medicine 2017; 4(1):1376898.
  33. Anjum KS, Alka NS. Electrolyte status in Preeclampsia. Online Internat Interdiscip Res J 2013; 3:30-6.
  34. Saha S, Singh YA, Naorem S, Marbaniang RS, Kshetrimayum V, Das T, et al. Correlation between Serum Sodium and Potassium Levels in Preeclampsia. Int J Biochem Res Rev 2020: 74-80.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 24, Issue 12
January 2022
Pages 35-42

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