The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial

Document Type : Original Article


1 Instructor, Department of Midwifery, Community Mental Health Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Professor, Department of Endocrinology, Endocrine and Metabolism Research Center, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Assistant professor, Department of Radiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

4 Professor, Department of Pharmacology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

5 Assistant professor, Department of Midwifery, Maternal-Fetal Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.


Introduction: Rapid bone loss after menopause is partly due to the formation of free radicals; the phenolic compounds of some plants eliminate these free radicals and most likely suppress bone destruction. This study was performed with aim to compare the effect of vitex and salvia officinalis extract on some osteogenic factors in postmenopausal women.
Methods: This triple-blind randomized clinical trial study was performed in 2015 on 99 postmenopausal women referred to the bone mass density center. The subjects were randomly divided into three groups of Vitex tablet, Salvia Officinalis extract and placebo; the intervention was performed for 3 months. Tests for osteogenic factors (alkaline phosphatase, osteocalcin, telopeptide-c (CTx)) were performed before and after the intervention. Chi-square, analysis of variance, paired t-test and LSD post hoc tests were used. P<0.05 was considered statistically significant.
Results: Mean alkaline phosphatase, osteocalcin and telopeptide-c decreased after the intervention compared to before the intervention in the vitex and salvia officinalis groups (p<0.001). Based on the results of LSD post hoc test, the difference between the mean scores of alkaline phosphatase (p <0.05), osteocalcin and telopeptide-c was significantly different between the vitex and salvia officinalis groups with the control group after the intervention (p <0.05), but the difference of mean score of telopeptide-c was not statistically significant between the vitex and salvia officinalis groups after the intervention (p = 0.118).
Conclusion: Vitex and Salvia Officinalis extract after the intervention were effective in reducing some estrogenic factors such as alkaline phosphatase, osteocalcin and telopeptide c after the intervention.


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