The effect of ondansetron and K-K9 Acupressure with ondansetron in treatment of nausea and vomiting of pregnancy

Document Type : Original Article


1 M.Sc. in Midwifery, Reproductive Health Promotion Research Center, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Ph.D. in Reproductive Health, Reproductive Health Promotion Research Center, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 M.Sc. in Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


Introduction: Nausea and vomiting in pregnancy is one of the most common problems during pregnancy. Given that there is no research on the use of a combination method of acupressure and antiemetic drugs in reducing nausea and vomiting in pregnancy, therefor, this study was performed with aim to compare the effect of ondansetron and K-K9 Acupressure with ondansetron in nausea and vomiting of pregnancy.
Methods: This randomized clinical trial study was performed in 2018-2019 on 84 pregnant women referred to Ahvaz teaching hospitals. The subjects were randomly divided in two groups of ondansetron with K-K9 acupressure and ondansetron alone. The severity and frequency of nausea and vomiting were recorded by Rhodes questionnaire for 8 days. At days of 1-5 days, both groups received ondansetron tablets 4 mg and in the ondansetron with K-K9 acupressure group in addition to ondansetron tablets, K-K9 acupressure was performed by the research unit. There was no intervention in the two groups on days 6-8. Data were analyzed using SPSS software (version 22) and independent t-test, Chi-square, paired t-test, and repeated measures. P<0.05 was considered statistically significant.
Results: During the intervention, there was significant difference between the two groups in the mean severity of vomiting (P˂0.001) and the mean severity of nausea (P = 0.01), but no significant difference was found between the two groups in the mean number of nausea (P = 0.08) and the mean number of vomiting (P = 0.05). Need to hospitalization and additional drug was less in ondansetron with K-K9 acupressure group, and also satisfaction of treatment was higher.
Conclusions: Ondansetron and K-K9 acupressure is more effective in reducing the severity of nausea and vomiting. Therefore, it is recommended to use ondansetron and K-K9 acupressure to reduce nausea and vomiting during pregnancy.


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