Investigating the Relationship between Glucose-6-Phosphate Dehydrogenase and Preeclampsia

Document Type : Original Article

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Guilan University of Medical Sciences, Guilan, Iran.

2 M.Sc. of Epidemiology, School of Medicine, Guilan University of Medical Sciences, Guilan, Iran.

3 Resident of Obstetrics and Gynecology, School of Medicine, Guilan University of Medical Sciences, Guilan, Iran.

Abstract

Introduction: Preeclampsia has high prevalence and important complications. According to the possibility of being a relationship between Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency and preeclampsia and the controversial results of few studies which done in this topic, the present study was carried out to investigate the relationship between G6PD and preeclampsia.
Methods: This case-control study was conducted on 115 postpartum women with or without preeclampsia. Sampling method was available. Demographic variables and clinical laboratory results (levels of G6PD enzyme, hemoglobin, red blood cells and reticulocytes) were assessed. Data were analyzed using SPSS software version 16 and kolmogorov-smirnov, t-test, non parametric and chi-square tests. P value less than 0.05 was considered significant.
Results: 115 women with mean age of 28.4±5.4 years were divided into two groups of postpartum women with history of preeclampsia (n=58) and without history of preeclampsia (n=57). The G6PD enzyme level (p<0.001) and reticulocytes level (p=0.005) were significantly lower in women with preeclampsia. There was significant difference in mean of systolic and diastolic blood pressure between two groups (p<0.001). But the differences of mean age (p=0.207), gravidity (p=0.194), gestational age (p=0.1), mean of hemoglobin (p=0.104) and mean of red blood cell (p=0.163) were not statistically significant in both groups.
Conclusion: G6PD enzyme and reticulocytes levels are significantly lower in women with preeclampsia.
 

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