The Effect of Anethum graveolen seed extract on Intestinal Function after cesarean section: a single-blind randomized clinical trial

Document Type : Original Article


1 M.Sc. student of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Instructor, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Specialist in Traditional Pharmacy, School of Traditional and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Introduction: Many women suffer from bloating and abdominal distension after cesarean section. This study was performed with aim to investigate the effect of Anethum graveolenseed extract on intestinal function after cesarean section.
Methods: This single-blind clinical trial study was performed on 80 cesarean section women in the hospitals of Mashhad University of Medical Sciences in 2019. Pregnant women were divided into intervention and control groups. The intervention group received Anethum graveolenseed extract 4 hours after cesarean section. Intestinal function was measured before the intervention up to 12 hours after cesarean section. It was measured using visual scale of bloating, tape meter and check list containing the first time of hearing intestinal sounds, flatulence and excretion. For the control group, only the intestinal function was measured as the intervention group. Data were analyzed using SPSS software (version 24) and Mann-Whitney, independent t, Chi-square, and Fisher's exact tests. P<0.05 was considered statistically significant.
Results: Mean of intensity of bloating was significantly different between the intervention and control groups (p<0.001). There was no statistically significant difference between the two groups in mean scores of abdominal distension (p<0.05). The mean time of hearing first intestinal sounds, flatulence and excretion after the surgery was significantly different between the intervention and control groups (p<0.001).
Conclusion: Consumption of dill seed drops improves the intestinal function after cesarean section.


  1. Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. 25nd ed.McGraw-Hill Education; 2018.
  2. Fitzpatrick KE, Kurinczuk JJ, Bhattacharya S, Quigley MA. Planned mode of delivery after previous cesarean section and short-term maternal and perinatal outcomes: A population-based record linkage cohort study in Scotland. PLoS medicine 2019; 16(9):e1002913.
  3. Hoseini Haji SZ, Firoozi M. Shared decision-making about birth after cesarean: review study. Iran J Obstet Gynecol Infertil 2020; 23(4):89-97.
  4. Mosadeghrad AM, Eslambolchi L. The futurology of normal birth promotion in Iran: letter to editor. Tehran University Medical Journal TUMS Publications 2019; 77(4):272-.
  5. Doherty GM. Current diagnosis and​ treatment surgery. McGraw-Hill; 2015.
  6. Potter PA, Perry AG, Hall AE, Stockert PA. Fundamentals of nursing. Elsevier mosby; 2009.
  7. Sun W, Li M, Lin T, Sun Z, Zhuang Z, Wen J, et al. Effectiveness of acupuncture for recovery of flatulence after cesarean section: A case report. Medicine 2018; 97(50).
  8. Ghorat F, Khadem E, Shirazi M, Rahimi R, Bioos S, Khademi A. Physiopathology and Treatment of Post-Operative Ileus in Viewpoint of Traditional Medicine and Classic Medicine: A Review Article. MEDICAL History 2015; 7(23):173-192.
  9. Schwartz SI, Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG. Schwartz's principles of surgery. 10nd ed. Mc Graw Hill Education; 2015.
  10. Shang H, Yang Y, Tong X, Zhang L, Fang A, Hong L. Gum chewing slightly enhances early recovery from postoperative ileus after cesarean section: results of a prospective, randomized, controlled trial. American journal of perinatology 2010; 27(05):387-91.
  11. Quah HM, Samad A, Neathey AJ, Hay DJ, Maw A. Does gum chewing reduce postoperative ileus following open colectomy for left‐sided colon and rectal cancer?–a prospective randomized controlled trial. Colorectal disease 2006; 8(1):64-70.
  12. Fazeli N, Tafazoli M, Ramezani M, Esmaeili H. The Effect of Supermint Oil on the Flatulence Intensity after Cesarean Section. Journal of Ardabil University of Medical Sciences (JAUMS) 2005; 4(14):41-46.
  13. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. The Journal of pediatrics 2001; 138(1):125-8.
  14. Sayah M, Peirouvi A, Kamalinezhad M. Anti-nociceptive effect of the fruit essential oil of Cuminum cyminum L. in rat. Iranian Biomedical Journal 2002; 6(4):141-145.
  15. Kellar SP, Kelvin EA. Munro's Statistical Methods for Health Care Research. 6nd ed. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012.
  16. Gharib Naseri MK, Haeidari A. Spasmolytic effect of Anethum graveolens (dill) fruit extract on rat ileum. Physiology and Pharmacology 2006; 10(2):99-105.
  17. Zargari A. Medicinal plants. Tehran University of Medical Sciences; 1997.
  18. Abasi Z, Alavi F, Salehian M, Rashidi Fakari F, Taherpour M, Farazmand T, et al. An investigation on the effect of chewing gum on gastrointestinal function after cesarean operation. Nursing And Midwifery Journal 2014; 12(3):214-20.
  19. Adeli M, ShamayianRazavi N, Kabiriyan M, Razmjoo N, Tara F. Comparison of Oral Intake Profiles at 4 and 12 Hours Following Cesarean Section under General Anesthesia. Journal of Torbat Heydariyeh University of Medical Sciences 2013; 1(3):7-15.
  20. Aali E, Mahmoudi R, Kazeminia M, Hazrati R, Azarpey F. Essential oils as natural medicinal substances. Tehran University Medical Journal TUMS Publications 2017; 75(7):480-9.
  21. Iovino P, Bucci C, Tremolaterra F, Santonicola A, Chiarioni G. Bloating and functional gastro-intestinal disorders: where are we and where are we going?. World Journal of Gastroenterology: WJG 2014; 20(39):14407.
  22. Jafarzade P, Mohseni Mehran SM, Moladoust H, Norasfard MR, Ghorbani A, Abedinzade M. Effect of hydroalcoholic extract of anethum graveolens l. Seed on tracheal smooth muscle contractions in male rats. Journal of Mazandaran University of Medical Sciences 2018; 28(160):146-50.
  23. Omidvar S, Nasiri-Amiri F, Bakhtiari A, Begum K. Clinical trial for the management dysmenorrhea using selected spices. Complementary therapies in clinical practice 2019; 36:34-8.
  24. Sakhavar N, Mirteimoori M. comparison of cuminum cyminum with milk of magnesia in prevention of gastrointestinal discomforts after emergentcesarean section. Journal of Babol University of Medical Sciences 2009; 10(6):42-48.
  25. Fazel N, Esmaili H. The effect of cumin oil on the flatulence intensity after cesarean section. KAUMS Journal (FEYZ) 2005; 9(3):8-12.
  26. Lubbers T, Buurman W, Luyer M. Controlling postoperative ileus by vagal activation. World journal of gastroenterology: WJG 2010; 16(14):1683.