Effect of selected elastic band resistance training on serum levels of fibroblast growth factor 23, TNF-α and hsCRP in overweight elderly women

Document Type : Original Article

Authors

1 Associate Professor, Department of Sport Sciences, School of Literature and Humanity Sciences, Shahrekord University, Shahrekord, Iran.

2 M.Sc. in Exercise Physiology, School of Literature and Humanity Sciences, Shahrekord University, Shahrekord, Iran.

Abstract

ntroduction: Chronic inflammation can be the main cause of many common diseases in old age. Elevated level of CRP and proinflammatory cytokines such as TNF-α is positively associated with fibroblast growth factor 23 (FGF23). Therefore, considering the potentially beneficial effect of elastic band resistance training (EBRT) on these variables, this study was performed with aim to investigate the effect of 12 weeks of selected EBRT on serum levels of FGF23, TNF-α and hsCRP in overweight elderly women.
Methods: This clinical trial study was performed in 2017 on 28 elderly women in Shahrekord.  The subjects were randomly divided into experimental and control groups. EBRT was performed for 12 weeks. Fasting blood samples were taken 24 hours before the first training session and 48 hours after the last training session to measure serum levels of FGF23, TNF-α and hsCRP. Data were analyzed by SPSS software (version 25) and repeated measure two-way ANOVA test. P<0.05 was considered statistically significant.
Results: EBRT had no significant effect on serum FGF23 levels, BMI, and Waist-to-hip ratio in elderly women (P>0.05); but serum levels of TNF-α (P=0.046), hsCRP (P=0.037), and also body fat percentage (P=0.023) significantly decreased after EBRT.
Conclusion: Regardless to no significant changes in FGF23 levels, it seems that 12 weeks of EBRT can have a significant effect on reducing chronic inflammation in the elderly by reducing the levels of hsCRP and proinflammatory cytokine TNF-α.

Keywords

References

  1. Kasović M, Štefan L, Zvonař M. More Time Spent in Sedentary Behaviors is Associated with Higher Plantar Pressures in Older Women. International journal of environmental research and public health 2020; 17(6):2089.
  2. Perkin OJ, Travers RL, Gonzalez JT, Turner JE, Gillison F, Wilson C, et al. Exercise strategies to protect against the impact of short-term reduced physical activity on muscle function and markers of health in older men: study protocol for a randomised controlled trial. Trials 2016; 17:381.
  3. Habibi A, Nemadi-Vosoughi M, Habibi S, Mohammadi M. Quality of life and prevalence of chronic illnesses among elderly people: A cross-sectional survey. Journal of Health 2012; 3(1):58-66.
  4. Sartori AC, Vance DE, Slater LZ, Crowe M. The impact of inflammation on cognitive function in older adults: implications for health care practice and research. The Journal of Neuroscience Nursing 2012; 44(4):206-17.
  5. Monteiro-Junior RS, de Tarso Maciel-Pinheiro P, Portugal ED, da Silva Figueiredo LF, Terra R, Carneiro LS, et al. Effect of exercise on inflammatory profile of older persons: systematic review and meta-analyses. Journal of Physical Activity and Health 2018; 15(1):64-71.
  6. Singh S, Grabner A, Yanucil C, Schramm K, Czaya B, Krick S, et al. Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease. Kidney international 2016; 90(5):985-96.
  7. Francis C, David V. Inflammation regulates fibroblast growth factor 23 production. Curr Opin Nephrol Hypertens 2016; 25(4):325-32.
  8. David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, et al. Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. Kidney Int 2016; 89(1):135-46.
  9. Zhang B, Yan J, Umbach AT, Fakhri H, Fajol A, Schmidt S, et al. NFκB-sensitive Orai1 expression in the regulation of FGF23 release. J Mol Med (Berl) 2016; 94(5):557-66.
  10. Czaya B, Faul C. The Role of Fibroblast Growth Factor 23 in Inflammation and Anemia. Int J Mol Sci 2019; 20(17):4195.
  11. Ito N, Wijenayaka AR, Prideaux M, Kogawa M, Ormsby RT, Evdokiou A, et al. Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli. Mol Cell Endocrinol 2015; 399:208-18.
  12. Fitzpatrick EA, Han X, Xiao Z, Quarles LD. Role of Fibroblast Growth Factor-23 in Innate Immune Responses. Front Endocrinol (Lausanne) 2018; 9:320.
  13. Glosse P, Fajol A, Hirche F, Feger M, Voelkl J, Lang F, et al. A high-fat diet stimulates fibroblast growth factor 23 formation in mice through TNFα upregulation. Nutr Diabetes 2018; 8(1):36.
  14. Durlacher-Betzer K, Hassan A, Levi R, Axelrod J, Silver J, Naveh-Many T. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney Int 2018; 94(2):315-325.
  15. Tuzun D, Oguz A, Aydin MN, Kurutas EB, Ercan O, Sahin M, et al. Is FGF-23 an early indicator of atherosclerosis and cardiac dysfunction in patients with gestational diabetes?. Archives of endocrinology and metabolism 2018; 62(5):506-13.
  16. Plaisance EP, Grandjean PW. Physical activity and high-sensitivity C-reactive protein. Sports Med 2006; 36(5):443-58.
  17. Walsh NP, Gleeson M, Pyne DB, Nieman DC, Dhabhar FS, Shephard RJ, et al. Position statement part two: maintaining immune health. Exerc Immunol Rev 2011; 17:64-103.
  18. Ertek S, Cicero A. Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions. Archives of medical science: AMS 2012; 8(5):794-804.
  19. Charansonney OL, Vanhees L, Cohen-Solal A. Physical activity: from epidemiological evidence to individualized patient management. International journal of cardiology 2014; 170(3):350-7.
  20. Hosseini Khakhk SA, Sharifi A, Hamedi Nia MR. A comparison of the effect of traditional resistance training with resistance training with vascular occlusion on ‌muscular function and cardiovascular endurance in young females. Sport Bioscience J 2011; 3(10):95-114.
  21. Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC, et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007; 39(8):1435-45.
  22. Martins WR, Safons MP, Bottaro M, Blasczyk JC, Diniz LR, Fonseca RM, et al. Effects of short term elastic resistance training on muscle mass and strength in untrained older adults: a randomized clinical trial. BMC Geriatr 2015; 15:99.
  23. Colado JC, Garcia-Masso X, Pellicer M, Alakhdar Y, Benavent J, Cabeza-Ruiz R. A comparison of elastic tubing and isotonic resistance exercises. Int J Sports Med 2010; 31(11):810-7.
  24. Huang SW, Ku JW, Lin LF, Liao CD, Chou LC, Liou TH. Body composition influenced by progressive elastic band resistance exercise of sarcopenic obesity elderly women: a pilot randomized controlled trial. Eur J Phys Rehabil Med 2017; 53(4):556-563.
  25. Li DJ, Fu H, Zhao T, Ni M, Shen FM. Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle. Metabolism 2016; 65(5):747-56.
  26. Fakhrpour R, Ebrahim K, Ahmadizad S, Khoroshahi HT. Effects of combined training on FGF23 and some vascular calcification risk factors in hemodialysis patients. Medical Journal of Tabriz University of Medical Sciences and Health Services 2016; 38(3):84-91.
  27. Keshavarzi ZA, Daryanoosh FA, Kooshki Jahromi M, Mohammadi ME. The effect of 12 weeks of aerobic exercise on plasma levels of fibroblast growth factor 23, Angiotensin converting enzyme and left ventricular hypertrophy in hypertensive elderly women. SSU_Journals 2017; 25(3):222-9.
  28. Zhou Y, Hellberg M, Hellmark T, Höglund P, Clyne N. Twelve months of exercise training did not halt abdominal aortic calcification in patients with CKD–a sub-study of RENEXC-a randomized controlled trial. BMC nephrology 2020; 21(1):233.
  29. Mendoza JM, Isakova T, Ricardo AC, Xie H, Navaneethan SD, Anderson AH, et al. Fibroblast growth factor 23 and Inflammation in CKD. Clinical Journal of the American Society of Nephrology 2012; 7(7):1155-62.
  30. Abd El-Kader SM, Al-Jiffri OH. Aerobic exercise modulates cytokine profile and sleep quality in elderly. African health sciences 2019; 19(2):2198-207.
  31. Zheng G, Qiu P, Xia R, Lin H, Ye B, Tao J, et al. Effect of aerobic exercise on inflammatory markers in healthy middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials. Frontiers in aging neuroscience 2019; 11:98.
  32. Shabani R, Yosefizad L, Fallah F. Effects of eight weeks of endurance-resistance training on some inflammatory markers and cardiovascular endurance in sedentary postmenopausal women. Iran J Obstet Gynecol Infertil 2017; 20(1):23-30.
  33. Azamian Jazi A, Emdi S, Hemati S. Effect of six weeks of continuous running on oxidative stress, lipid peroxidation and aerobic power in female survivors of breast cancer. Iran J Obstet Gynecol Infertil 2017; 19(38):24-32.
  34. Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, et al. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget 2018; 9(24):17181-98.
  35. Ihalainen JK, Schumann M, Eklund D, Hämäläinen M, Moilanen E, Paulsen G, et al. Combined aerobic and resistance training decreases inflammation markers in healthy men. Scand J Med Sci Sports 2018; 28(1):40-7.
  36. Taghian F, Ghatreh Samani K. Dose 12 week resistance training Influence IL-18 and CRP levels in Elderly men?. Razi Journal of Medical Sciences 2018; 24(165):77-84.
  37. Kohut ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD, et al. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults. Brain, behavior, and immunity 2006; 20(3):201-9.
  38. Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society 2004; 52(7):1098-104.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 24, Issue 1
March 2021
Pages 26-35

Files

Share

How to cite

Statistics