Prevalence of Chlamydia trachomatis infection and its effect on semen of infertile men referred to infertility clinics in Tabriz

Document Type : Original Article

Authors

1 Assistant professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

2 Assistant Professor, Department of Infectious Diseases, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Assistant Professor, Department of Infectious and tropical Diseases, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Introduction: Chlamydia trachomatis in men can be a cause of infertility which sometimes is not considered in the infertility criteria; on the other hand, this infection has adverse effects on the morphology of semen. Regarding to the unknown prevalence and destructive effects of this infection on semen, this study was performed with aim to investigate the prevalence of Chlamydia trachomatis infection and its effect on semen of infertile men referred to infertility clinics in Tabriz.
Methods: In this descriptive study, which was performed during 2015 with the participation of 268 infertile men referred to infertility clinics affiliated to Tabriz University of Medical Sciences, the prevalence of Chlamydia trachomatis infection in men and its effect on semen were investigated. Data were compared by SPSS software (version 20) and t-test. P<0.05 was considered statistically significant.
Results: The prevalence of Chlamydia trachomatis infection in infertile men was 35.82%; the morphological results of semen analysis showed that the number (P=0.009), progressive movement (P=0.026), morphology (P=0.001) and viability (P=0.003) of men sperm with chlamydia trachomatis infection was significantly lower than men without infection, while volume (P=0.012), in situ movement (P=0.009), sperm immobility (P=0.008) was significantly higher in men with infection than men without infection.
Conclusion: Incidence of Chlamydia trachomatis infection was higher than normal in the present study and this infection has led to destructive effects on semen morphology.

Keywords


  1. Klevens RM, Edwards JR, Richards CL Jr, Horan TC, Gaynes RP, Pollock DA, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007; 122(2):160-6.
  2. Aghamohammadi D, Mehdinavaz Aghdam A, Khanbabayi Gol M. Prevalence of Infections Associated with Port and Predisposing Factors in Women with Common Cancers Under Chemotherapy Referred to Hospitals in Tabriz in 2015. Iran J Obstet Gynecol Infertil 2019; 21(11):7-13.
  3. CCDR (Canada Communicable Disease Report). Sexually transmitted infections. CCDR 2017; 43.
  4. Haghdoost M, Mousavi S, Gol MK, Montazer M. Frequency of Chlamydia trachomatis infection in spontaneous abortion of infertile women during first pregnancy referred to tabriz university of medical sciences by nested PCR method in 2015. International Journal of Women's Health and Reproduction Sciences 2019; 7(4):526-30.
  5. Smith L, Angarone MP. Sexually transmitted infections. Urologic Clinics 2015; 42(4):507-18.
  6. Fuchs W, Brockmeyer NH. Sexually transmitted infections. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 2014; 12(6):451-64.
  7. Scott HM, Klausner JD. Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US. AIDS Res Ther 2016; 13:5.
  8. Matteelli A, Capelli M, Sulis G, Toninelli G, Carvalho ACC, Pecorelli S, et al. Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infection in adolescents in Northern Italy: an observational school-based study. BMC Public Health 2016; 16:200.
  9. Goshayeshi L, Vahid Roudsari F, Ghazvini K, Nomani H, Amel Jamehdar S. Pilot prevalence evaluation of Chlamydia Trachomatis by PCR in female infertile referred to study center of infertility in Mashhad. ISMJ 2015; 18(1):92-9.
  10. Han JS, Rogers ME, Nurani S, Rubin S, Blank S. Patterns of chlamydia/gonorrhea positivity among voluntarily screened New York City public high school students. J Adolesc Health 2011; 49(3):252-7.
  11. Asbel LE, Newbern EC, Salmon M, Spain CV, Goldberg M. School-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae among Philadelphia public high school students. Sexually transmitted diseases 2006; 33(10):614-20.
  12. Papp JR, Schachter J, Gaydos CA, Van Der Pol B. Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae—2014. MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommendations and reports/Centers for Disease Control 2014; 63:1.
  13. Owusu-Edusei Jr K, Bohm MK, Chesson HW, Kent CK. Chlamydia screening and pelvic inflammatory disease: Insights from exploratory time–series analyses. American journal of preventive medicine 2010; 38(6):652-7.
  14. Price MJ, Ades AE, De Angelis D, Welton NJ, Macleod J, Soldan K, et al. Risk of pelvic inflammatory disease following Chlamydia trachomatis infection: analysis of prospective studies with a multistate model. American journal of epidemiology 2013; 178(3):484-92.
  15. Dukers-Muijrers NH, Schachter J, van Liere GA, Wolffs PF, Hoebe CJ. What is needed to guide testing for anorectal and pharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae in women and men? Evidence and opinion. BMC Infect Dis 2015; 15:533.
  16. Geisler WM. Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies. J Infect Dis 2010; 201 Suppl 2:S104-13.
  17. Pattanasin S, Dunne EF, Wasinrapee P, Tongtoyai J, Chonwattana W, Sriporn A, et al. Screening for Chlamydia trachomatis and Neisseria gonorrhoeae infection among asymptomatic men who have sex with men in Bangkok, Thailand. Int J STD AIDS 2018; 29(6):577-587.
  18. Moazenchi M, Totonchi M, Salman Yazdi R, Hratian K, Mohseni Meybodi MA, Ahmadi Panah M, et al. The impact of Chlamydia trachomatis infection on sperm parameters and male fertility: A comprehensive study. Int J STD AIDS 2018; 29(5):466-473.
  19. Dehghan Marvast L, Talebi AR, Ghasemzadeh J, Hosseini A, Pacey AA. Effects of Chlamydia trachomatis infection on sperm chromatin condensation and DNA integrity. Andrologia 2018; 50(3):e12918.
  20. Dehghan Marvast L, Aflatoonian A, Talebi AR, Ghasemzadeh J, Pacey AA. Semen inflammatory markers and Chlamydia trachomatis infection in male partners of infertile couples. Andrologia 2016; 48(7):729-36.
  21. Sellami H, Znazen A, Sellami A, Mnif H, Louati N, Ben Zarrouk S, et al. Molecular detection of Chlamydia trachomatis and other sexually transmitted bacteria in semen of male partners of infertile couples in Tunisia: the effect on semen parameters and spermatozoa apoptosis markers. PLoS One 2014; 9(7):e98903.
  22. Liu J, Wang Q, Ji X, Guo S, Dai Y, Zhang Z, et al. Prevalence of Ureaplasma urealyticum, Mycoplasma hominis, Chlamydia trachomatis infections, and semen quality in infertile and fertile men in China. Urology 2014; 83(4):795-9.
  23. Samplaski MK, Domes T, Jarvi KA. Chlamydial infection and its role in male infertility. Advances in Andrology 2014; 2014.