Evaluation of Spatial Memory in Women with Polycystic Ovary Syndrome

Document Type : Original Article

Authors

1 Professor, Department of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

2 General Physician, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Instructor, Department of Emergency and Critical Care, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran.

4 Instructor, Department of Nursing, School of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

5 B.Sc., Department of Nursing, School of Nursing, Maragheh Branch, Islamic Azad University, Maragheh, Iran.

6 Professor, Department of Obstetrics and Gynecology, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

7 M.Sc. of Epidemiology, Psychiatry and Behavioral Sciences Research Center, Tabriz University of Medical Science, Tabriz, Iran.

Abstract

Introduction: Polycystic ovary syndrome is a common endocrine disorder in women of reproductive age. This syndrome may affect cognitive function and impair spatial memory. Therefore, this study was performed with aim to evaluate spatial memory in women with polycystic ovary syndrome.
Methods: This correlation descriptive study was performed in 2013 on 50 women with polycystic syndrome and 50 women without polycystic syndrome who were selected among those referring to specialized obstetrics and gynecology clinics. PCO criterion was used to diagnose polycystic ovary syndrome and Computer Spatial Working Memory Test was used to assess spatial memory. Then the score of spatial memory of the two groups were analyzed by SPSS software (version 21) and independent t-test, Chi-square and Pearson correlation test. p < 0.05 was considered statistically significant.
Results: Mean scores of spatial memory test in case and control groups were 0.52±0.88± 0.39±06 and, respectively. The difference in cognitive performance between the case and control groups was statistically significant (P <0.0001) and women with this syndrome had better performance than the control group. Also, spatial memory scores were significantly correlated with age (p = 0.002), but not significantly correlated with education level (p = 0.99) and body mass index (p = 0.38).
Conclusion: Patients with polycystic ovary syndrome had better spatial memory, but since this capability originates from a pathological process, it does not imply an overall improvement in cognitive function, so, comprehensive follow up of these patients and possible complications of the disease may be necessary.

Keywords

References

  1. Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 2013; 6:1‐13.
  2. Shayan A, Masoumi SZ, Shobeiri F, Ahmadinia H. Analysis of the factors affecting polycystic ovary syndrome. Iran J Obstet Gynecol Infertil 2017; 19(36):11-18.
  3. Ibáñez L, Oberfield SE, Witchel S, et al. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence. Horm Res Paediatr 2017; 88(6):371‐395.
  4. Qi X, Pang Y, Qiao J. The role of anti-Müllerian hormone in the pathogenesis and pathophysiological characteristics of polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2016; 199:82‐87.
  5. Deswal R, Nanda S, Dang AS. Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome. Syst Biol Reprod Med. 2019;65(5):400‐408.
  6. Korol DL, Pisani SL. Estrogens and cognition: Friends or foes?: An evaluation of the opposing effects of estrogens on learning and memory. Horm Behav 2015; 74:105‐115.
  7. Phan A, Suschkov S, Molinaro L, et al. Rapid increases in immature synapses parallel estrogen-induced hippocampal learning enhancements. Proc Natl Acad Sci U S A 2015; 112(52):16018‐16023.
  8. Barry JA, Parekh HS, Hardiman PJ. Visual-spatial cognition in women with polycystic ovarian syndrome: the role of androgens. Hum Reprod 2013; 28(10):2832‐2837.
  9. Schattmann L, Sherwin BB. Testosterone levels and cognitive functioning in women with polycystic ovary syndrome and in healthy young women [published correction appears in Horm Behav. 2007 Aug;52(2):280]. Horm Behav 2007; 51(5):587‐596.
  10. Halari R, Hines M, Kumari V, et al. Sex differences and individual differences in cognitive performance and their relationship to endogenous gonadal hormones and gonadotropins. Behav Neurosci 2005; 119(1):104‐117.
  11. Zangeneh F. Polycystic ovary syndrome and sympathoexcitation: management of stress and lifestyle. J Biol Today's World 2017; 6(8):146-54.
  12. Huang-Doran I, Franks S. Genetic Rodent Models of Obesity-Associated Ovarian Dysfunction and Subfertility: Insights into Polycystic Ovary Syndrome. Front Endocrinol (Lausanne) 2016; 7:53.
  13. Cooney LG, Milman LW, Hantsoo L, Kornfield S, Sammel MD, Allison KC, et al. Cognitive-behavioral therapy improves weight loss and quality of life in women with polycystic ovary syndrome: A pilot randomized clinical trial. Fertility and sterility 2018; 110(1):161-71. e1.
  14. Bahrami H, Mohseni M, Amini L, Karimian Z. The effect of six weeks yoga exercises on quality of life in infertile women with polycystic ovary syndrome (PCOS). Iran J Obstet Gynecol Infertil 2019; 22(5):18-26.
  15. Alekseichuk I, Turi Z, Amador de Lara G, Antal A, Paulus W. Spatial Working Memory in Humans Depends on Theta and High Gamma Synchronization in the Prefrontal Cortex. Curr Biol 2016; 26(12):1513‐1521.
  16. Van de Weijer-Bergsma E, Kroesbergen EH, Prast EJ, Van Luit JE. Validity and reliability of an online visual-spatial working memory task for self-reliant administration in school-aged children. Behav Res Methods 2015; 47(3):708‐719.
  17. soltanlo M, Olyaei GH, Tehrani Dost M, Abdolvahab M, Bagheri H, Faghihzadeh S. Comparison of spatial working memory and strategy use in cerebral palsy children with normal subjects with 7-12 years old. Journal of Modern Rehabilitation 2008; 2(1):9-14.
  18. Sheikh M, Ramezani SH, Maghsoudy G, Ahmadi K. The Effects of Spark Training on Visual-Spatial Working Memory Operation in Children with Mental Retardation. Shefaye Khatam 2019; 7(3):13-22.
  19. Kawwass JF, Sanders KM, Loucks TL, Rohan LC, Berga SL. Increased cerebrospinal fluid levels of GABA, testosterone and estradiol in women with polycystic ovary syndrome. Hum Reprod 2017; 32(7):1450‐1456.
  20. Ross JL, Kushner H, Kowal K, et al. Androgen Treatment Effects on Motor Function, Cognition, and Behavior in Boys with Klinefelter Syndrome. J Pediatr 2017; 185:193‐199.e4.
  21. Flannigan R, Patel P, Paduch DA. Klinefelter Syndrome. The Effects of Early Androgen Therapy on Competence and Behavioral Phenotype. Sex Med Rev 2018; 6(4):595‐606.
  22. Stangl B, Hirshman E, Verbalis J. Administration of dehydroepiandrosterone (DHEA) enhances visual-spatial performance in postmenopausal women. Behav Neurosci 2011; 125(5):742‐752.
  23. Huang G, Wharton W, Travison TG, et al. Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose-response randomized trial. J Endocrinol Invest 2015; 38(4):455‐461.
  24. Moodley K, Minati L, Contarino V, et al. Diagnostic differentiation of mild cognitive impairment due to Alzheimer's disease using a hippocampus-dependent test of spatial memory. Hippocampus 2015; 25(8):939‐951.
  25. Haimov-Kochman R, Berger I. Cognitive functions of regularly cycling women may differ throughout the month, depending on sex hormone status; a possible explanation to conflicting results of studies of ADHD in females. Front Hum Neurosci 2014; 8:191.
  26. Burnham V, Sundby C, Laman-Maharg A, Thornton J. Luteinizing hormone acts at the hippocampus to dampen spatial memory. Horm Behav 2017; 89:55‐63.
  27. Davari S, Reisi P. Role of Insulin in Cognitive Functions of the Central Nervous System. Journal of Isfahan Medical School 2013; 31(227).
  28. Johansson P, Åberg D, Johansson JO, et al. Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease. Psychoneuroendocrinology 2013; 38(9):1729‐1737.
  29. Kort JD, Winget C, Kim SH, Lathi RB. A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility. Fertil Steril 2014; 101(5):1400‐1403.
  30. Barnard L, Balen AH, Ferriday D, Tiplady B, Dye L. Cognitive functioning in polycystic ovary syndrome. Psychoneuroendocrinology 2007; 32(8-10):906‐914.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 23, Issue 5
July 2020
Pages 1-9

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