Effect of Vitex agnus-castus plant on sexual function in women of reproductive age

Document Type : Original Article

Authors

1 M.Sc. student of Midwifery, Student Research Committee, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Assistant professor, Department of Obstetrics and Gynecology, Reproductive Health Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

3 Professor, Department of Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Associate professor, Department of Pharmacology, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Assistant professor, Department of Biostatistics, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

6 Associate professor, Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Introduction: It is important to pay attention to the sexual function of women of childbearing age due to long-term conflict with it and its impact on personal health, marital relations and childbearing. The phytoestrogenic effect of the Vitex agnus-castus plant on sexual function of postmenopausal women as well as in limited animal studies has been shown to improve, enhance sexual behavior and hormones, but it has not been studied in women of childbearing age. Therefore, this study was performed with aim to determine the effect of Vitex agnus-castus plant consumption on sexual dysfunction in women of childbearing age.
 Methods: This double-blind clinical trial study was performed on 102 women referred to Alzahra Women's Clinic of Rasht for doing Pap smears in 2019. Eligible candidates completed the Female Sexual Function Index (FSFI) questionnaire; if they were placed in the group of sexual dysfunction and then randomly assigned to two groups of Vitex agnus-castus tablet or placebo. FSFI questionnaire was again completed after 4 weeks. Data were analyzed by SPSS software (version 21) and Chi-square, Fisher, Mann-Whitney, Independent-t and paired t-test. P<0.05 was considered statistically significant.
Results: Two groups were homogeneous in terms of demographic, social and midwifery characteristics, and mean scores of total sexual function and domains were similar between the two groups before the (p≥0.05). After one month of the intervention, mean score of total sexual function and domains was not statistically significant between two groups (p≥0.05). In comparison of the scores within-group, only the score of orgasm domain was improved (p=0.02).
Conclusion: There was no change in sexual function of women before and after the intervention; so it is recommended that given the mechanism of the effects of phytoestrogens and similar studies in postmenopausal women, this study be conducted over a long period of time.

Keywords


  1. SadocK BJ, Sadock VA, Ruiz P. Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry. 11nd Ed. Philadelphia: Lippincott Williams & Winlkinson; 2014.
  2. Wolpe RE, Zomkowski K, Silva FP, Queiroz APA, Sperandio FF. Prevalence of female sexual dysfunction in Brazil: a systematic review. Eur J Obstet Gynecol Reprod Biol 2017; 211:26-32.
  3. Ghiasi A, Keramat A. Prevalence of Sexual Dysfunction among Reproductive-age Women in Iran: A Systematic Review and Meta-analysis. Journal of Midwifery and Reproductive Health 2018; 6(3):1390-1398.
  4. Tahmasebi H, Abasi E. Sexual function and its relation with depression in referring women to health centers affiliated to medical science university in Sari Township. Family Health (Journal of Helth Breeze) 2013; 1(3):40-44.
  5. Shakarami M, Davarnia R, Zahrakar K, Gohari S. The effect of sex education on sexual intimacy of married women. Iranian Journal of Psychiatric Nursing 2014; 2(1):34-42.
  6. Nappi RE, Cucinella L, Martella S, Rossi M, Tiranini L, Martini E. Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Maturitas 2016; 94:87-91.
  7. Sobecki JN, Curlin FA, Rasinski KA, Lindau ST. What we don't talk about when we don't talk about sex: results of a national survey of U.S. obstetrician/gynecologists. J Sex Med 2012; 9(5):1285‐1294.
  8. ISSWSH/NAMS Consensus Committee. ISSWSH position statement. J Sex Med 2014; 11(5):1109.
  9. Lipshultz LI, Pastuszak AW, Goldstein AT, Giraldi A, Perelman MA. Management of Sexual Dysfunction in Men and Women: An Interdisciplinary Approach Springer; 2016.
  10. Sumalatha K, Kumar S, Lakshmi SM. Review on natural aphrodisiac potentials to treat sexual dysfunction. Int J Pharm Ther 2010; 1(1):6-14.
  11. Chauhan NS, Sharma V, Dixit VK, Thakur M. A review on plants used for improvement of sexual performance and virility. Biomed Res Int 2014; 2014:868062.
  12. Shifren JL. Overview of sexual dysfunction in women: Management [Internet]. Up to Date; 2020.
  13. Abdnejad R, Simbar M. A review on herbal medicines effective of premenstrual syndrome in Iran. Iran J Obstet Gynecol Infertil 2016; 19(11):18-30.
  14. Sadeghi T, Azimi A, Loripoor M. Comparing the effect of black Cohosh versus Vitagnus on the impovement of menopause symptoms. Iran J Obstet Gynecol Infertil 2019; 21(12):1-10.
  15. Rani A, Sharma A. The genus Vitex: A review. Pharmacogn Rev 2013; 7(14):188‐198.
  16. van Die MD, Burger HG, Teede HJ, Bone KM. Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013; 79(7):562‐575.
  17. Mirheidar H. Botany application of plants in prevention and treatment of diseases. Tehran: Daftar-e Nashr-e-Farhang Islami; 2003.
  18. Upton R, Pharmacopoeia AH. Chaste Tree Fruit: Vitex Agnus-castus: Standards of Analysis, Quality Control, and Therapeutics: American Herbal Pharmacopoeia; 2001.
  19. Peggy Hsu P. Natural medicines comprehensive database. J Med Libr Assoc 2002; 90(1):114.
  20. Hoffmann D. Medical herbalism: the science and practice of herbal medicine. 1nd ed. Healing Arts Press: Simon and Schuster; 2003. p. 672.
  21. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003; 10(4):348‐357.
  22. Jarry H, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V. Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones. Planta Med 2003; 69(10):945‐947.
  23. Heuzé-Joubert I, Mennecier P, Simonet S, Laubie M, Verbeuren TJ. Effect of vasodilators, including nitric oxide, on the release of cGMP and cAMP in the isolated perfused rat kidney. European journal of pharmacology 1992; 220(2-3):161-71.
  24. Konishi M, Su C. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension.1983; 5(6):881‐886.
  25. Durand S, Davis SL, Cui J, Crandall CG. Exogenous nitric oxide inhibits sympathetically mediated vasoconstriction in human skin. J Physiol 2005; 562(Pt 2):629‐634.