The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Effect of high intensity interval training and use of Echium amoenum on serum ferritin and CRP levels in overweight and obese women

Document Type : Original Article

Authors
Maryam Nasri 1
Farzaneh Taghian 2
1 M.Sc. of Sport Physiology, School of Physical Education and Sport Science, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
2 Associate professor, Department of Sport Physiology, School of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
10.22038/ijogi.2020.15739
Abstract
Introduction: During obesity, inflammatory markers such as ferritin and C-reactive protein are increased, which is a major mechanism of atherosclerosis and insulin resistance. Regular exercise and medication can reduce these factors and reduce the risk of chronic diseases. This study was performed with aim to compare the effect of 12 weeks of high intensity interval training (HIIT) and use of borage (Echium amoenum L.) on serum CRP and ferritin levels in overweight and obese women.
Methods: This randomized clinical trial study was performed on 40 overweight and obese women in 2018. The subjects were randomly divided into four groups of 10 cases in each group (Exercise-Supplement, Exercise, Supplement and Control). Blood samples were collected and analyzed before and after 12 weeks to measure the levels of CRP and ferritin. A high intensity interval training program (85-95% of maximal heart rate) was performed three times a week for 12 weeks, and groups that used Echium amoenum daily received 4 g dissolved in 250 ml of water, for 12 weeks. Data were analyzed by SPSS software (version 21) and Paired t-test and covariance tests and Shapirowilk and Levin tests. PResults: After 12 weeks HIT training, serum ferritin levels increased after the intervention compared to the pre-intervention, so that this increase was significant in the training group (p=0.033) and Echium amoenum group (p=0.016), but was not significant in the training-Echium amoenum group (p=0.323) and control group (p=0.612). Also, CRP decreased after the intervention compared to the pre-intervention, so that this decrease was significant in the training group (p=0.05) and Echium amoenum group (p=0.001), but was not significant in the training-Echium amoenum group (p=0.196) and control group (p=0.571).
Conclusion: Performing severe intermittent exercise along with use of Echium amoenum supplementation by reducing CRP and increasing serum ferritin level can improve the complications and diseases caused by obesity. It has also had an impact on general obesity.
Keywords
CRP
Echium amoenum supplement
Ferritins
HIT training
  1. Fathi R, Nazarali P, Adabi Z. Effect of 8 week resistance training on omentin levels and insulin resistance index in Obese and overwight women. Journal of Applied Exercise Physiology 2014; 10(19):109-119. (Persian).
  2. Schrager MA, Metter EJ, Simonsick E, Ble A, Bandinelli S, Lauretani F, et al. Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol (1985) 2007; 102(3):919-25.
  3. Albert MA, Ridker PM. The Role of C-reactive Protein in Cardiovascular Disease Risk. Curr Cardiol Rep 1999; 1(2):99-104.
  4. Tchernof A, Nolan A, Sites CK, Ades PA, Poehlman ET. Weight Loss Reduces C-reactive protein Levels in Obese Postmenopausal Women. Circulation 2002; 105(5):564-9.
  5. Turgeon O'Brien , Blanchet R, Gagné D, Lauzière J, Vézina C. Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. Anemia 2016; 2016:6430214.
  6. Haidari F, Haghighi-Zade MH, Kayedani GA, Birgani NK. Evaluation of the relationship between iron status with obesity and obesity-induced inflammation in female students. Tehran University Medical Journal 2018; 76(2):129-134.
  7. Boutcher SH, Dunn SL. Factors that may impede the weight loss response to exercise-based interventions. Obes Rev 2009; 10(6):671-80.
  8. Naseri N, Kalantar K, Amirghofran Z. Anti-inflammatory activity of Echium amoenum extract on macrophages mediated by inhibition of inflammatory mediators and cytokines expression. Res Pharm Sci 2018; 13(1):73-81.
  9. Salimi Avansar M, Abdolsaleh Z. Comparing the Effect of Endurance and High Intensity Interval Trainings on Levels of Chemerin and Protein of C-reactive Plasma in Obese Children. Arak Medical University Journal 2017; 20(119):54-66.
  10. Heydari Sharif Abadi B, Taghian F. The Impact of Intensity Interval Training and Supplementation of Green Tea on Serum Levels of Irisin, Insulin Resistance in Obese Women with Type 2 Diabetes Women. Iranian Journal of Diabetes and Metabolism 2018; 17(6):307-316. (Persian).
  11. Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports Med 2015; 45(5):679-92.
  12. Ghasemi Dehkordi N. Iranian Herbal Pharmacopoeia. Iranian Herbal Pharmacopoeia Editing Committee. 1nd ed. Teh: Ministry of Health, Medical Education; 2002. p. 667.
  13. Mohammadi Jozani S, Emad M, Khanjanzadeh R, Gheibi F, Rasooli M. Medicinal - Industrial Borage.1nd ed. Teh: Pooneh; 2012. p. 44.
  14. Taghian F, Kargarfard M, Kelishadi R. Effects of 12 Weeks Aerobic Training on Body Composition, Serum Homocysteine and CRP Levels in Obese Women. Journal of Isfahan Medical School 2011; 29(149):1037-45.
  15. Martins RA, Verissimo MT, Coelho e Silva MJ, Cumming SP, Teixeira AM. Effects of aerobic and strength-based training on metabolic health indicators in older adults. Lipids Health Dis 2010; 9(76):184-220.
  16. Namazi A, Aghaalinejad H, Peeri M, Rahbarizadeh F. The Effects of Short Term Circuit Resistance Training on Serum Homocysteine and CRP Concentrations in Active and Inactive Females. Iranian Journal of Endocrinology and Metabolism 2010; 12(2):169-176.
  17. Hubner-Wozniak E, Ochocki P. Effects of training on resting plasma levels of homocysteine and C-reactive protein in competitive male and female wrestlers. Biomedical Human Kinetics 2009; 25(1):42-46.
  18. Buchan DS, Olis S, Young JD, Thomas NE, Cooper SM, Tong TK, et al. The effects of Time and Intensity of Exercise on Novel and Established Markers of CVD in Adolescent Youth. Am J Hum Biol 2011; 23(4):517-26.
  19. Zolfi HR, Sari SarrafV, Babaei H, Amirsasan R. The effect of grape seed (vitis vinifera L.) extract supplementation on lipid profile and high-sensitivity C- reactive protein levels after aerobic exercise in non-athlete males. Feyz 2015; 19(3):204-213.
  20. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, et al. Exercise training and plasma C- reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 2008; 56(11):2045-52.
  21. Malekyian Fini E, Shavandi N, Saremi A, Tabibi Rad S. Effect of short-term Resvin supplementation on total antioxidant capacity‚ super oxide dismutase, and creatine kinase in elite women volleyball players. Iranian Journal of Nutrition Sciences & Food Technology 2013; 8(3):79-86.
  22. Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, et al. Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J physiol 2004; 558(2):633-45.
  23. Okita M, Hayashi M, Sasagawa T, Takagi K, Suzuki K, Kinoyama S, et al. Effect of a Moderately Energy-Restricted Diet on Obese Patients With Fatty Liver. J Nutrition 2001; 17(7-8):542-7.
  24. Devaraj S, Jialal I. α-Tocopherol Decreases Interleukin-1β Release From Activated Human Monocytes by Inhibition of 5-Lipoxygenase. Arteriosclerosis, Thrombosis, and Vascular Biology 1999; 19(4):1125-33.
  25. Marcell TJ, McAuley KA, Traustadottir T, Reaven PD. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 2005; 54(4):533-41.
  26. Bahram ME, Najarian M, Pourvaghar MJ. Relationship between blood homocysteine and maximum oxygen consumption in intactive men. Daneshvar Medicine 2014; 21(110).
  27. Ishii T, Yamakita T, Tanaka S, Fujii S. Resistance training improves insulin sensitivity in NIDDM Subjects without altering maximal oxygen uptake. Diabetes Care 1998; 21(8):1353-5.
  28. Powers Sk, Ji LL, Leeuwenburgh C. Exercise training induced alterations in skeletal muscle antioxidant. Capacity: a brief review. Med Sci Sports Exerc 1999; 31(7):987-97.
  29. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Plasma concentration of C- reative protein and risk of developing peripheral vascular Disease. Circulation 1998; 97(5):425-8.
  30. Toorang F, Jazayery A, Jalali M. Effects of Omega-3 Fatty Acids Supplement on Antioxidant Enzymes Activity in Type 2 Diabetic Patients. Iran J Public Health 2016; 45(3):340-45. (Persian).
  31. Wong PC, Chia MY, Tsou IY, Wansaicheong GK, Tan B, Wang JC, et al. Effects of a 12-week Exercise Training Programme on Aerobic Fitness, Body Composition, Blood Lipids and C-Reactive Protein in Adolescents with Obesity. Ann Acad Med Singapore 2008; 37(4):286-93.
  32. Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, et al. An anti-inflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab 2010; 95(9):E1-8.
  33. Auobi Asl R, Taghian F. The effect of eight weeks of pilates training and consumption of β-glucan on plasma concentrations of obestatin and cholecystokinin in overweight women. Razi Journal of Medical Sciences 2019; 25(11):1-12.
  34. Pahlevaninejad S, Taghian F. Comparing the Effects of Eight-Week Zinc Supplementation and Yoga Exercise on Serum Apelin Level and Kidney Function Among Women with Type II Diabetes Mellitus. Mod Care J 2019; 16(2):457-92. (Persian).
  35. Lakka TA, Laaksonen DE . Physical activity in prevention and treatment of the metabolic syndrome. Appl physiol Nutr Metab 2007; 32(1):76-88.
  36. Hamedinia MR, Amiri Parsa T, Azarnive MS, Hosseini Kakhk AR. The Effect of Resistance Training, Aerobic Training and Detraining on the Lipid Profile and CRP in Obese Girls. Journal of Sabzevar University of Medical Sciences 2011; 18(3):188-97. (Persian).
  37. Glaister M. Multiple sprint work: physiological responses, mechanisms of fatigue and the influence of aerobic fitness. Sports Med 2005; 35(9):757-77.
  38. Khoshkam F, Taghian F, Jalali Dehkordi K. Effect of eight weeks of supplementation of omega-3 supplementation and TRX training on visfatin and insulin resistance in women with polycystic ovary syndrome. Iran J Obstet Gynecol Infertil 2018; 21(9):58-70.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 23, Issue 1
March 2020
Pages 79-87