Changes in prevalence and epidemiology of female genital cancers in northeastern Iran in a 35-year study

Document Type : Original Article

Authors

1 Resident, Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Professor, Department of Obstetrics and Gynecology, Women's Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Community medicine specialist, Department of Community Medicine, Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Associate professor, Department of Oncology, Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

5 General Physician, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

6 General Physician, Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

7 Community medicine specialist, Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

8 Associate professor, Department of Community Medicine, Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Gynecologic cancers are the important cause of women's mortality in the world. Considering the importance of epidemiological recognition of gynecologic cancers in regional form for planning the preventive measures, this study was performed with aim to assess the epidemiologic characteristics of patients with gynecologic cancers referring to Mashhad oncologic centers in 1982-2016.
Methods: In this cross-sectional study, after evaluation of all patients’ files recorded in the last 35 years, the required data were extracted and recorded. The study period was categorized into 4 intervals: before 1990, 1991-2000, 2001-2010, and 2011-2016. The relative frequency, mean age at the time of diagnosis, and the 35-year trend were then assessed. Data were analyzed by SPSS software (version 16) and Chi-Square, Anova, and Scheffe tests. P Results: Among 2953 studied patients, mean age was (49.32 ± 13.69 years. The highest mean age was observed among the patients with uterine body neoplasms (52.21±12.49) and the lowest mean age in those with ovarian cancer (46.09±16.09). The mean age at the time of diagnosis of ovarian cancer has significantly increased in the last decades (p<0.001) while decreased in those with cervical cancer (p=0.017). Cervical and ovarian cancers had the highest relative frequency during the entire study period (39.3% (1161 cases) and 36.6% (1080 cases), respectively). There was also a significant difference in the frequency of various cancers across different decades (p<0.001).
Conclusion: Cervical cancer was the most frequent neoplasm in this study. The mean age of diagnosis had increased in patients with ovarian cancer and decreased in cervical cancer. Since cervical cancer can be controlled by preventive measures, more attention to screening of this cancer is recommended.

Keywords

References

  1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC cancer base no. 11 [Internet]. International Agency for Research on Cancer, Lyon; 2013. Available from: http://www.globocan.iarc.fr. [Last accessed on 2016 Sep 24].
  2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136(5):E359-86.
  3. Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture. Eur J Cancer 2001; 37 Suppl 8:S4-66.
  4. Khajehkazemi R, Sadeghirad B ,Karamouzian M, Fallah MS, Mehrolhassani MH, Dehnavieh R, et al. The projection of burden of disease in Islamic Republic of Iran to 2025. PLoS One 2013; 8(10):e76881.
  5. Kim K, Zang R, Choi SC, Ryu SY, Kim JW. Current status of gynecological cancer in China. J Gynecol Oncol 2009; 20(2):72-76.
  6. Tabrizi AD, Alizadeh M, Sayyah-Melli M, Jafari M, Madarek E. Incidence rate of cervical cancer and precancerous lesions in East Azarbayjan, Iran. Asia-Pac J Clin Oncol 2006; 2(2):87-90.
  7. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin 1999; 49(1):33-64.
  8. Center for disease control. National cancer registration report, 2008. Tehran: Ministry of health and medical education; 2012.[Persian]
  9. Mitchell RS, Padwal RS, Chuch AW, Klarenbach SW. Cancer screening among the overweight and obese in Canada. Am J Prev Med 2008; 35(2):127-32.
  10. Amant F, Van Calsteren K, Halaska MJ, Beijnen J, Lagae L, Hanssens M, et al. Gynecologic cancers in pregnancy: guidelines of an international consensus meeting. Int J Gynecol Cancer 2009; 19 Suppl 1:S1-12.
  11. Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012; 62(4):220-41.
  12. Gilani MM, Behnamfar F, Zamani F, Zamani N. Frequency of different types of ovarian cancerin Vali-e-Asr hospital. (Tehran University of Medical Sciences) 2001-2003. Pak J Biol Sci 2007; 10(17):3026-8.
  13. Razi S, Salehiniya H, Fathali Loy Dizaji M. Epidemiology of prevalent cancer among Iranian women and its incidence trends from 2003-2009 in Iran. J Arak Univ Med Sci 2015; 18(2):17-24.
  14. Taherian AA, Fatahie E. Study of Effective Factors in Cervical Cancer in Isfahan. Journal of Guilan University of Medical Sciences 2001; 10(37-38):6-12.
  15. Sasco AJ, Ah-Song R, Gendre I, Zlatoff P, Bobin JY, Hallonet P, et al. Cancer de l’endomètre et tamoxifène. Discussion à partir d’une série de cas. Bulletin du cancer 1997; 84(1):51-60.
  16. Nojomi M, Modares Gilani M, Erfani A, Mozafari N, Mottaghi A. The study of frequency of risk factors of cervical cancer among women attending general hospitals in Tehran, 2005-2006. Razi J Med Sci 2007; 14(56):189-95.
  17. Turgut A, Özler A, Sak ME, Evsen MS, Soydinç HE, Alabalık U, et al. Jinekolojik kanserli olguların retrospektif analizi: 11 yıllık deneyim. Journal of Clinical and Experimental Investigations 2012; 3(2):209-13.
  18. Razavi E, Aghajani H, Haghazali M. The most common cancers in Iranian women. Iranian Journal of Public Health 2009; 38(Suppl 1):109-112.
  19. Anderson KC, Alsina M, Bensinger W, Biermann JS, Chanan-Khan A, Cohen AD, et al. NCCN clinical practice guidelines in oncology: multiple myeloma. J Natl Comprehen Cancer Network 2009; 7(9):908.
  20. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61(2):69-90.
  21. Mohammed A, Ahmed SA, Oluwole OP, Avidime S. Malignant tumours of the female genital tract in Zaria, Nigeria: Analysis of 513 cases. Ann African Med 2006; 5(2):93-96.
  22. Arab M, Khayamzadeh M, Mohit M, Hosseini M, Anbiaee R, Tabatabaeefar M, et al. Survival of ovarian cancer in Iran: 2000-2004. Asian Pac J Cancer Prev 2009; 10(4):555-8.
  23. Bray F, Loos AH, Tognazzo S, La Vecchia C. Ovarian cancer in Europe: Cross-sectional trends in incidence and mortality in 28 countries, 1953-2000. Int J Cancer 2005; 113(6):977-90.
  24. Hirabayashi Y, Marugame T. Comparison of time trends in ovary cancer mortality (1990-2006) in the world, from the WHO Mortality Database. Jpn J Clin Oncol 2009 ;39(12):860-1.
  25. Lotfi MH, Amiri F. Evaluation of 5 Years Trend of Occurrence for the Genital System Carcinoma Amongst Women Yazd Province -2006-2010. Journal of Community Health Research 2015; 4(1):65-73.
  26. Dolinsky C, Taylor J. Endometrial cancer: the basics. Pennsylvania: Abramson Cancer Center of the University of Pennsylvania. 2013.
  27. Babazadeh M, Porali L, Ataran N, Nikfarjam Z, Masodi T, Salehi M. Demographic survey of 600 patients with gynecologic cancers in Mashhad, Iran in 1985-2012. Iran J Obstet Gynecol Infertil 2016; 19(3):1-8.
  28. Furau G, Dascau V, Furau C, Paiusan L, Radu A, Stanescu C. Gynecological cancer age groups at the "Dr. salvator vuia" clinical obstetrics and gynecology hospital during the 2000-2009 Period. Maedica (Buchar) 2011; 6(4):268-71.
  29. Bassey EA, Ekpo MD, Abasiatai A. Female genital tract malignancies in Uyo, South-South Nigeria. Niger Postgrad Med J 2007; 14(2):134-6.
  30. Emami Razavi S, Aaghajani H, Haghazali M, Nadali F, Ramazani R, Dabiri E, et al. The Most Common Cancers in Iranian Women. Iran J Public Health 2009; 38(Supple 1):109-112.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 22, Issue 12
February 2020
Pages 11-18

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