The Relationship between Uterine Leiomyoma with Premature Rupture of Membranes in Pregnant Women

Document Type : Original Article

Authors

1 Assistant professor, Department of Obstetrics and Gynecology, Laparoscopy Fellowship, Pregnancy Health Research Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

2 PhD student in Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Medical Student, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

4 Assistant professor, Department of Obstetrics and Gynecology, Infertility Fellowship, Pregnancy Health Research Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract

Introduction: Uterine leiomyoma is the most prevalent benign uterine tumor in women which develop in nearly 20-40% of women of reproductive age. Pregnancy in women with uterine leiomyoma is considered as a high-risk pregnancy that lead to many complications. This study was performed with aim to investigate the relationship of uterine leiomyoma with premature rupture of membranes in pregnant women.
Methods: This descriptive-analytical study was conducted on 500 pregnant women referred to Ali-ibn Abi Talib Hospital in Zahedan from April 2015 to March2017.
The qualified pregnant women were divided into two groups of leiomyoma and non-leiomyoma, based on the presence of uterine lymphoma diagnosed in early pregnancy ultrasound. Two groups were examined for number, size and location of leiomyoma. Data were analyzed using SPSS software (version 21), descriptive and Chi-square tests. P
Results: Among 500 pregnant women who were included in the study, 18.6% (N=93) had uterine lymphoma and 81.4% (N=407) were without uterine leiomyoma. The prevalence of premature rupture of the membrane in the uterine leiomyoma group was 25.85% (N=24) and 9.33% (N=38) in without uterine leiomyoma group. There was significant relationship between premature rupture of membranes with the number and location of uterine lymphoma in pregnant women (p <0.001).
Conclusion: There was significant relationship between premature rupture of membranes with uterine leiomyoma (number, size and location). Premature rupture of membranes was more prevalent in intramural mayoma and in mayoma with diameter more than 5 cm.

Keywords

References

  1. Geethamala K, Murthy VS, Vani BR, Rao S. Uterine leiomyomas: an ENIGMA. J Midlife Health 2016; 7(1):22-7.
  2. Bromberg JV, Goldberg J, Rychlak K, Weinstein L. The effects of uterine fibroid on pregnancy outcomes. Proceedings of the Advances in Uterine Leiomyoma Research: NIH 2nd International Congress, Bethesda; 2005.
  3. Gurmeet LC, Patel LC, Mansingh CS. A successful management of myoma complicating pregnancy by conservative treatment: a case report. Int J Sci Res 2018; 6:10.
  4. Hadnott TN, Parker W. Myomas and pregnancy. Non-obstetric surgery during pregnancy. New York: Springer; 2019. P. 283-92.
  5. Noor S, Fawwad A, Sultana R, Bashir R, Jalil H, Suleman N, et al. Pregnancy with fibroids and its obstetric complications. J Ayub Med Coll Abbottabad 2009; 21(4):37-40.
  6. Ouyang DW, Economy KE, Norwitz ER. Obstetric complications of fibroids. Obstet Gynecol Clin 2006; 33(1):153-69.
  7. McKenzie F, Edmonds BT. Offering induction of labor for 22-week premature rupture of membranes: a survey of obstetricians. J Perinatol 2015; 35(8):553-7.
  8. Medina TM, Hill DA. Preterm premature rupture of membranes: diagnosis and management. Am Fam Physician 2006; 73(4):659-64.
  9. ACOG Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol 2007; 109(4):1007-19.
  10. Caughey AB, Robinson JN, Norwitz ER. Contemporary diagnosis and management of preterm premature rupture of membranes. Rev Obstet Gynecol 2008; 1(1):11-22.
  11. Hashemnezhad M. Obstetric outcomes in pregnant women with and without uterine leiomyoma. Ann Mil Health Sci Res 2008; 6(2):123-9.
  12. Qidwai GI, Caughey AB, Jacoby AF. Obstetric outcomes in women with sonographically identified uterine leiomyomata. Obstet Gynecol 2006; 107(2):376-82.
  13. Shavell VI, Thakur M, Sawant A, Kruger ML, Jones TB, Singh M, et al. Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertil Steril 2012; 97(1):107-10.
  14. Iqbal M, Akhtar Z, Jamal T. Outcome of pregnancies associated with fibroids. J Med Sci 2014; 22(1):3-5.
  15. Majeed T, Waheed F, Sattar Y, Mobusher I, Saba K. Impact of uterine fibroids on the obstetric performance of the women; complications and pregnancy outcome. Pak J Med Sci 2011; 5:274-7.
  16. Stout MJ, Odibo AO, Graseck AS, Macones GA, Crane JP, Cahill AG. Leiomyomas at routine second-trimester ultrasound examination and adverse obstetric outcomes. Obstet Gynecol 2010; 116(5):1056-63.
  17. Wang HM, Tian YC, Xue ZF, Zhang Y, Dai YM. Associations between uterine fibroids and obstetric outcomes in twin pregnancies. Int J Gynecol Obstet 2016; 135(1):22-7.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 22, Issue 1
March 2019
Pages 15-19

Files

Share

How to cite

Statistics