Effect of Grape Seed Powder on Postpartum Hemorrhage in Vaginal Delivery: A Randomized Controlled Clinical Trial

Document Type : Original Article

Authors

1 Instructor, Department of Nursing, East Nursing and Midwifery Research Center, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.

2 M.Sc. Student in Nursing education, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.

3 Instructor, Department of Midwifery, East Nursing and Midwifery Research Center, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.

4 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

5 Assistant Professor, Department of Public Health, Social Determinants of Health Research Center, School of Health, Birjand University of Medical Sciences, Birjand, Iran

Abstract

Introduction: Postpartum hemorrhage is one of the most major problems that threaten the mothers' health and is regarded as one of the most important reasons for mortality especially in developing countries. So far, many studies have been conducted with regard to the effectiveness of chemical and herbal medicine on the decrease of postpartum hemorrhage. Given the importance of postpartum bleeding management for mother and child, this study aimed to evaluate the effect of grape seed powder on postpartum hemorrhage.
Methods: This randomized controlled clinical trial study was performed on 120 pregnant women referred to Vali-e-Asr Maternity Hospital of Birjand in 2016. The mothers were randomly divided into four groups each one with 30 cases. The three groups received grape seed powder doses of 50, 100, and 150 mg and there was a placebo group. The capsules were taken by the mother with a glass of warm water after taking the pair. The volume of maternal hemorrhage was measured 24 hours after the delivery. Data were analyzed by SPSS software (version 16) using one-way analysis of variance, Tukey's test, and Bonferroni post hoc test. P-value less than 0.05 was considered statistically significant.
Results: In all four groups, the bleeding volume from the first to the third hour showed a significant decrease )P<0/001(. At the first, second, and third hours after the intervention, the highest volume of bleeding in the control group and the lowest volume of bleeding in the intervention group with 100 mg of grape seed were observed. In the control group, the highest volume of bleeding was 24 h and in the 150-mg group the lowest volume of bleeding was observed. There was a significant difference between the mean volume of 24 h bleeding in the four groups and the mean volume of bleeding in all groups was also significant in the control group )P<0/001(.
Conclusion: Grape seed powder seems to be safe and effective for preventing postpartum hemorrhage and is recommended to use in the third stage of labor.

Keywords

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 21, Issue 10
December 2018
Pages 30-37

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