Document Type : Original Article
Authors
1
M.Sc. Student of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Assistant professor, Department of Midwifery, Evidence-Based Health Care Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Instructor, Department of Nursing, Evidence-Based Caring Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Associate Professor, Department of Nanotechnology and Nanotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
Introduction: Cesarean section is one of the most common gynecological surgeries and pain is one of the most common problems after that. The silver nanoparticles with anti-inflammatory mechanism may be useful in reducing pain. Therefore, this study was performed with aim to determine the effect of silver nanoparticles (Nivasha ) spray on the intensity of cesarean wound pain.
Methods: This triple-blind randomized controlled clinical trial was performed on 92 women with cesarean section in Mashhad Omolbanin educational hospital in 2017. Research units were randomly assigned in 3 groups. In two groups, Nyvasha and placebo spray was used on the caesarian wound twice a day for 10 consecutive days and each time 3 puffs; the control group didn’t receive any drug. The intensity of pain was measured 20-28 hours after cesarean section and on the 5th and 10th days after it by Visual Analogue Scale. Data was analyzed by SPSS software (version 16) and Chi-square test and Kruskal Wallis test. P ˂ 0.05 was considered statistically significant.
Results: After the intervention, the mean of pain intensity on day 5 in the silver nanoparticles, placebo, and control groups were 2.2 ± 1.1, 4.8 ± 1.3, 4.7±1.3 and on day 10 in the silver nanoparticles, placebo and control groups were 0.1 ± 0.4, 2.4 ± 1.5 and 2.0 ± 1.6, respectively. There was statistically significant difference in the pain intensity reduction in the silver nanoparticles group compared to the other two groups (P<0.001), however there was no significant difference between placebo and control group on day 5 (P = 0.84) and on day 10 (P = 0.37).
Conclusion: Regarding the decrease in the intensity of cesarean section pain after the intervention, spray silver nanoparticles (Nivasha) is recommended as a suitable drug for reducing post-cesarean section pain in mothers.
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