Evaluation of Early and Late Complications of Amniocentesis in Ommolbanin Hospital in Mashhad, Iran during 2014-2016

Document Type : Original Article

Authors

1 Professor, Department of Obstetrics and Gynecology, Women's Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran .

2 Associate Professor, Department of Obstetrics and Gynecology, Women's Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Assistant Professor, Department of Obstetrics and Gynecology, Women's Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Amniocentesis is usually performed to genetically assess the fetus before birth. The most common complications associated with amniocentesis include the rupture of membrane (ROM), miscarriage, amniocentesis, as well as direct and indirect harm to fetus. The study aimed to evaluate the early and late complications of amniocentesis.
Methods: This cohort study was conducted on 1,000 pregnant women, who referred to the Perinatology Clinic of Ommolbanin Hospital in Mashhad, Iran during 2014-2016 to undergo amniocentesis by a perinatologist. To obtain 20 cc amniotic fluid, a needle was inserted into the gestational sac through the skin of the abdominal area of mothers using the ultrasound guidance. Subsequently, the researchers collected the data related to the early and late complications, pregnancy termination date, and neonatal complications through phone calls. Data analysis was performed in SPSS version 20 using Kolmogorov-Smirnov test.
Results: From the evaluated neonates, 887 newborns (88.7%) were healthy. According to the results, spontaneous abortion, amniotic fluid leakage, spotting, amnionitis, and childbirth before 37 weeks of gestation were reported in 10 (1%), 16 (1.6%), 16 (1.6%), 2 (0.2%), and 173 (17.3%) of the cases, respectively. Furthermore, there were no reports of ocular, dermatologic and orthopedic complications in the study.
Conclusion: According to the results of the study, the most common early complications of amniocentesis were spotting and amniotic fluid leakage. Furthermore, preterm birth was the most common late complication of this procedure.

Keywords

References

  1. Eddleman KA, Malone FD, Sullivan L, Dukes K, Berkowitz RL, Kharbutli Y, et al. Pregnancy loss rates after midtrimester amniocentesis. Obstet Gynecol 2007; 108(5):1067-72.
  2. Mazza V, Pati M, Bertucci E, Re C, Ranzi A, Percesepe A, et al. Age-specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases. Prenat Diagn 2007; 27(2):180-3.
  3. Berkowitz RL, Bussel JB, McFarland JG. Alloimmune thrombocytopenia: state of the art 2006. Am J Obstet Gynecol 2006; 195(4):907-13.
  4. Halliday JL, Lumley J, Sheffield LJ, Robinson HP, Renou P, Carlin JB. Importance of complete follow-up of spontaneous fetal loss after amniocentesis and chorion villus sampling. Lancet 1992; 340(8824):886-90.
  5. Welch RA, Salem-Elgharib S, Wiktor AE, Van Dyke DL, Blessed WB. Operator experience and sample quality in genetic amniocentesis. Am J Obstet Gynecol 2006; 194(1):189-91.
  6. Hockstein S, Chen PX, Thangavelu M, Pergament E. Factors associated with maternal cell contamination in amniocentesis samples as evaluated by fluorescent in situ hybridization. Obstet Gynecol 1998; 92(4 Pt 1):551-6.
  7. Risch HA, Weiss NS, Clarke EA, Miller AB. Risk factors for spontaneous abortion and its recurrence. Am J Epidemiol 1988; 128(2):420-30.
  8. Niederstrasser SL, Hammer K, Möllers M, Falkenberg MK, Schmidt R, Steinhard J, et al. Fetal loss following invasive prenatal testing: a comparison of transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis. J Perinat Med 2017; 45(2):193-8.
  9. Beta J, Lesmes-Heredia C, Bedetti C, Akolekar R. Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. Minerva Ginecol 2017; 70(2):215-9.
  10. Tara F, Lotfalizadeh M,Moeindarbari S. The effect of diagnostic amniocentesis and its complications on early spontaneous abortion. Electron Physician. 2016 Aug 25;8(8):2787-2792. eCollection 2016 Aug.
  11. Kalman CW, Leung TN, Leung TY, Chan LW, Sahota DS, Fung TY, et al. Risk factors for procedure-related fetal losses after mid-trimester genetic amniocentesis. Prenat Diagn 2013; 26(10):925-30.
  12. Weisz B, Rodeck CH. Invasive diagnostic procedures in twin pregnancies. Prenat Diagn 2005; 25(9):751-8.
  13. Mazza V, Pati M, Bertucci E, Cani C, Latella S, Gargano G, et al. Second trimester amniocentesis is not a risk factor for very low birth weight and extremely low birth weight. ISRN Obstet Gynecol 2011; 2011:313206.
  14. Kong CW, Leung TN, Leung TY, Chan LW, Sahota DS, Fung TY, et al. Risk factors for procedure-related fetal losses after mid-trimester genetic amniocentesis. Prenat Diagn 2006; 26(10):925-30.
  15. Isenberg SJ, Heckenlively JR. Traumatized eye with retinal damage from amniocentesis. J Pediatr Ophthalmol Strabismus 1985; 22(2):65-7.
  16. Monteagudo B, del Pozo J, Suárez-Traba B, Sacristán F. Skin dimpling as a complication of amniocentesis: histopathologic findings. Actas Dermosifiliogr 2013; 104(8):729-31.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 21, Issue 3
May 2018
Pages 1-4

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