Frequency of pregnancy and its predicting factors in IUI cycles at Milad Infertility Center during 2011-2013

Document Type : Original Article


1 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, Iran.

2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, Iran.

3 General Practitioner, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, Iran.


Introduction: High incidence of infertility in our society (24.9%) is considered as a main problem. Intrauterine insemination (IUI) due to its low cost and non-invasiveness is selected as a first-line treatment for infertility treatment in assisted reproductive technique. This study was performed with aim to evaluate the frequency of pregnancy and its predicting factors in IUI cycles.
Methods: This cross-sectional study was performed on 308 infertile couples who had referred to Milad infertility center during 2011-2013. A total of 370 IUI cycles were performed for infertile women. Infertile women underwent Letrozole regimen along with recombinant FSH, and after monitoring by transvaginal ultrasound, when observing at least one mature follicle with size over 16 mm, HCG (5000 IU intramuscularly) was injected. 36 hours later, IUI was performed. IUI success and pregnancy rate were confirmed by pregnancy test and transvaginal ultrasound. Data was analyzed by SPSS software (version 16). PResults: The overall pregnancy rate was 23.8% in this study. The factors such as less IUI cycles (P=0.035), existence of just one known infertility factor (P=0.01), at least two mature follicles (P=0.001), endometrial thickness of at least 10mm (P=0.003), no use of tenaculum (P=0.01), ratio of progressive motile sperm more than 50% (P=0.015) and Total Motile Functional Sperm more than 5 million (P=0.015) significantly affect pregnancy rate. The woman's age (P =0.08), duration of infertility (P =0.94), type and etiology of infertility (P =0.083) and sperm concentration (P=0.269) and sperm morphology (P=0.67) did not significantly affect the pregnancy rate.
Conclusion: Less IUI cycles, existence of just one known infertility factor, at least two mature follicles, endometrial thickness of at least 10mm, no use of tenaculum, ratio of progressive motile sperm more than 50%, and TMFS more than 5 million are significantly effective on pregnancy rate in IUI cycles.


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