The effect of 12 weeks of Pilates exercises on ghrelin serum level and appetite in women with type 2 diabetes

Document Type : Original Article

Authors

1 PhD student of Exercise Physiology, Department of Sports Sciences, School of Humanities, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

2 Assistant Professor of Exercise Physiology, Department of Exercise Science, School of Humanities, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

3 Assistant Professor, Department of Sports Sciences, School of Humanities, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

10.22038/ijogi.2024.73467.5775

Abstract

Introduction: An increase in appetite and lack of enough movement accelerates the process of contracting chronic diseases, including diabetes, so the present study was conducted with aim to investigate the effect of 12 weeks of Pilates exercises on ghrelin serum levels and appetite in women with type 2 diabetes.
Methods: This experimental study was conducted on women with type 2 diabetes (from the Najafabad Diabetes Association) with an age range of 35 to 55 years in Najafabad city. People were randomly divided into experimental and control groups. The first group performed Pilates exercises for 12 weeks incrementally, 3 sessions a week and each session lasted 50 minutes, and for the control group who continued the routine life program, before and after the implementation of the exercise protocol, blood was taken and ghrelin was measured by Eliza method. Data was analyzed by SPSS software (version 22) and Mann-Whitney test. P<0.05 was considered statistically significant.
Results: The result showed that performing 12 weeks of Pilates exercises was significant on the serum level of ghrelin (P≤0.001), feelings of hunger (P≤0.001), feelings of fullness (P≤0.001), feelings of satiety (P≤0.001) and feeling of desire for food (P≤0.001) in women with type 2 diabetes.
Conclusion: Pilates exercises can improve the serum level of ghrelin and appetite, therefore Pilates exercises may be an effective treatment method for women with type 2 diabetes.

Keywords

Main Subjects


  1. Hill-Briggs F, Adler NE, Berkowitz SA, Chin MH, Gary-Webb TL, Navas-Acien A, et al. Social determinants of health and diabetes: a scientific review. Diabetes care 2021; 44(1):258-79.
  2. Bergmann NC, Gasbjerg LS, Heimbürger SM, Krogh LS, Dela F, Hartmann B, et al. No acute effects of exogenous glucose-dependent insulinotropic polypeptide on energy intake, appetite, or energy expenditure when added to treatment with a long-acting glucagon-like peptide 1 receptor agonist in men with type 2 diabetes. Diabetes Care 2020; 43(3):588-96.
  3. Afrasyabi S, Marandi SM, Kargarfard M. The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight. Journal of Diabetes & Metabolic Disorders 2019; 18:107-17.
  4. Akalu Y, Molla MD, Dessie G, Ayelign B. Physiological effect of ghrelin on body systems. International journal of endocrinology 2020; 2020.
  5. Mills JG, Larkin TA, Deng C, Thomas SJ. Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin. Psychiatry research 2019; 279:244-51.
  6. Mani BK, Shankar K, Zigman JM. Ghrelin’s relationship to blood glucose. Endocrinology 2019; 160(5):1247-61.
  7. Pulkkinen L, Ukkola O, Kolehmainen M, Uusitupa M. Ghrelin in diabetes and metabolic syndrome. International journal of peptides 2010; 2010.
  8. Malin SK, Heiston EM, Gilbertson NM, Eichner NZ. Short-term interval exercise suppresses acylated ghrelin and hunger during caloric restriction in women with obesity. Physiology & Behavior 2020; 223:112978.
  9. Mifune H, Tajiri Y, Sakai Y, Kawahara Y, Hara K, Sato T, et al Voluntary exercise is motivated by ghrelin, possibly related to the central reward circuit. Journal of Endocrinology 2020; 244(1):123-32.
  10. Beaulieu K, Blundell JE, van Baak MA, Battista F, Busetto L, Carraça EV, et al. Effect of exercise training interventions on energy intake and appetite control in adults with overweight or obesity: A systematic review and meta‐analysis. Obesity reviews 2021; 22:e13251.
  11. Sabzevari F, Mogharnasi M, Golestani F. Effect of 6 weeks Pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocalin-2, and insulin resistance in females with overweight and obesity: A randomized controlled trial. Journal of Research in Medical Sciences 2022; 27(1):59.
  12. Chen Z, Ye X, Wang Y, Shen Z. Effect of pilates on glucose and lipids: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Physiology 2021; 12:641968.
  13. Habibi A, Aghamohammadi M, Khajehlandi M. Examine the effects of exercise training on serum levels of Ghrelin and Pilates index of insulin resistance in overweight inactive women. Research on Medicine 2017; 41(2):130-7.
  14. Yosefi Chermahini Z, Taghian F, Hedayati M. Effects of Combined Training on the Levels of Obestatin, Ghrelin, and Insulin Resistance in Overweight Women. Journal of Research and Health 2020; 10(5):287-94.
  15. Akhtegan S, Atashak S, Roshdi Bonab R. The changes of some total antioxidant capacity and lipid peroxidation markers following the combined with high intensity interval training in sedentary postmenopausal women. The Iranian Journal of Obstetrics, Gynecology and Infertility 2022; 24(13):70-9.
  16. Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. International journal of obesity 2000; 24(1):38-48.
  17. Zakavi I, Zakavi E, Taghiyan F. Effect of pilates training on plasma levels of ghrelin and obestatin in obese older men. SSU_Journals 2015; 23(3):2021-31.
  18. Ouerghi N, Feki M, Bragazzi NL, Knechtle B, Hill L, Nikolaidis PT, et al. Ghrelin response to acute and chronic exercise: Insights and implications from a systematic review of the literature. Sports medicine 2021; 51(11):2389-410.
  19. Heden TD, Liu Y, Kanaley JA. Impact of exercise timing on appetite regulation in individuals with type 2 diabetes. Medicine and science in sports and exercise 2016; 48(2):182.
  20. Ronveaux CC, Tomé D, Raybould HE. Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling. The Journal of nutrition 2015; 145(4):672-80.