تأثیر تمرین مقاومتی بر شاخص مچ پایی بازویی، فشارخون و پروتئین 4 مورفوژنتیک استخوان در زنان مبتلا به نوروپاتی محیطی دیابت نوع 2: یک کارآزمایی بالینی تصادفی شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشکده تربیت بدنی، دانشگاه صنعتی شاهرود، شاهرود، ایران.

2 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشکده تربیت بدنی، دانشگاه صنعتی شاهرود، شاهرود، ایران.

چکیده

مقدمه: به‌نظر می‌رسد عملکرد عروقی در پیشرفت دیابت نقش داشته باشد، مطالعه حاضر با هدف بررسی اثر تمرین مقاومتی بر شاخص مچ پایی بازویی، فشارخون و BMP-4 در زنان مبتلا به دیابت نوروپاتی محیطی انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی در سال 1403 بر روی 28‌ زن ‌دیابتی ‌نوع ‌‌‌‌2 مبتلا‌ به ‌نوروپاتی ‌محیطی (نمره بالای 7 میشیگان) انجام شد. افراد در دو گروه تمرین مقاومتی (13 نفر) و گروه کنترل (15 نفر) قرار گرفتند. گروه تمرین مقاومتی به‌‌مدت ۱۲ هفته، تمرین شامل ۱۱ حرکت با شدت 60-۵۰% از قدرت بیشینه و ۳-1 ست پیش‌رونده (هر ۴ هفته یک ست افزایش) در سه روز هفته انجام دادند. قبل از اولین جلسه و 48 ساعت پس از آخرین جلسه تمرین، فشارخون، شاخص پایی‌بازویی (ABI) و شاخص‌های تن‌سنجی اندازه‌گیری و خونگیری نیز انجام شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (27 نسخه) و آزمون تی وابسته و تحلیل کوواریانس انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته ­ها: در شاخص پایی بازویی (011/0=p)، فشارخون سیستولی (02/0=p)، قند خون (001/0=p)، مقاومت به انسولین (001/0=p) و 4-BMP (001/0=p) بر اساس مقادیر کوواریانس در مقادیر گروه تمرین به نسبت گروه کنترل کاهش معناداری وجود داشت؛ اما برای متغیرهای وزن، شاخص توده بدنی، درصد چربی و فشارخون دیاستولی تفاوت معنادار نبود (05/0<p).
نتیجه­ گیری: با توجه به نتایج، 4-BMP طی تمرینات مقاومتی کاهش پیدا کرده و به‌نظر می‌رسد این کاهش می‌تواند در ارتباط با تغییرات شریانی به واسطه تمرین باشد، ولی نیاز به تحقیقات بیشتر در این زمینه احساس می‌شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Resistance Training on Brachial Ankle Index, Blood Pressure and Bone Morphogenetic Protein 4 in Type-2 Diabetic Women With Peripheral Neuropathy: A Randomized Clinical Trial

نویسندگان [English]

  • Naeimeh Nourmohammadian 1
  • Adel Donyaei 2
1 M.Sc. in Sports Physiology, Department of Physical Education and Sports Sciences, School of Physical Education, Shahrood University of Technology, Shahrood, Iran.
2 Assistant Professor of Sports Physiology, Department of Physical Education and Sport Sciences, School of Physical Education, Shahrood University of Technology, Shahrood, Iran.
چکیده [English]

Introduction: It seems that vascular function plays a role in the development of diabetes; the present study was conducted with aim to investigate the effect of resistance training on ankle-brachial index, blood pressure and bone morphogenetic protein 4 in women with diabetic peripheral neuropathy.
Methods: This randomized clinical trial study was conducted in 2024 on 28 type 2 diabetic women with peripheral neuropathy (Michigan Score higher than 7).The subjects were placed in two groups of resistance training (n=13) and control (n=15). The training group performed 12 weeks of 1RM training including 11 movements at intensity of 50-60% of maximum strength and 1-3 progressive sets (increasing by one set every 4 weeks) performed three days a week. Before the first session and 48 hours after the last training session, blood pressure, brachial plexus index (ABI), and anthropometric indices were measured and blood sampling was collected. Data analysis was performed using SPSS statistical software (version 27) and dependent t-test and analysis of covariance. P<0.05 was considered significant.
Results: In ankle-brachial index (P=0.011), systolic blood pressure (P=0.02), blood sugar (P=0.001), insulin resistance (P=0.001) and 4-BMP (P=0.001) based on the covariance values, there was a significant decrease in the values ​​of the training group compared to the control group; However, there was no significant difference for weight, body mass index, fat percentage and diastolic blood pressure (P>0.05).
Conclusion: According to the results, BMP-4 decreased during resistance training and it seems that the decrease may be related to exercise-induced arterial changes, but needs more research in this field.

کلیدواژه‌ها [English]

  • Ankle Brachial Index
  • Bone Morphogenetic Protein 4
  • Diabetic Neuropathy
  • Resistance Training

مراجع

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مجله زنان، مامایی و نازایی ایران
دوره 28، شماره 11
بهمن 1404
صفحه 58-67

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