The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Effect of eight Weeks Aerobic Training on Serum parathormone, estrogen and Alkaline phosphatase concentration in obese women with premature menopause

Document Type : Original Article

Authors
Mehrdad Fathi 1
Seyed Reza Attarzadeh Hosseini 2
Somayeh khair abadi 3
Keyvan Hejazi 3
1 Associate professor, Department of Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
2 Professor, Department of Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
3 PhD Student in Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
10.22038/ijogi.2017.9503
Abstract
Introduction: Osteoporosis is the most common metabolic bone disease that could causes many dangerous fractures. In this condition bone mass reduces, so fractures can easily occur. The aim of this study was assessing the effect of eight weeks of aerobic training on serum parathormone, estrogen and Alkaline phosphatase concentration in Women with premature menopause.
Methods: Methods: In this study semi-experimental study, in 2014, 21 women with premature menopause (age 35-45 year, body mass index (BMI>30 kg/m2), height: 161.19±2.64 and weight 83.97±1.98) were selected by convenience sampling method and they were randomly divided into two groups experimental (n=10) and control (n=11). The subject in experimental group had an aerobic training program for eight week (3 sessions in week, each session 45-60 minutes, the intensity of exercise was 65 to 75 percent of maximum heart rate). Blood samples were taken from the subjects’ 24 hours before the first session and 48 hours after the last training session at end of eight week in order to measure factors such as (parathyroid hormone (PTH), estrogen and some bone metabolism) by using a radioimmunoassay (RIA) and ELISA method in 12 hours of fasting. Then Data for inter and between group comparison, paired and ANCOVA test were used (significance level p<0.05).
Results: The result of this study show that, eight weeks aerobic training lead to a significant increase in mean values of serum calcium (p=0.001), phosphor (p=0.001), estrogen (p=0.001), parathormone (p=0.001) in aerobic training group; while, the amount of alkaline phosphatase did not change at the end of period (p=0.92).
Conclusion: Eight weeks aerobic training with 65 to 75 percent of maximum heart rate intensity was efficient in increasing of serum calcium, phosphor, estrogen, parathormone in women with premature menopause. It is concluded that regular training can help to increase bone density and reduces the risk of fractures in women with premature menopause.
Keywords
Parathormone
Estrogen
Alkaline phosphatase
Calcium
Aerobic training
  1. Sato Y, Abe T. KAATSU-walk training increases serum bone-specific alkaline phosphatase in young men. Int J KAATSU Train Res 2005; 1(2):77-81.
  2. Rizzoli R, Åkesson K, Bouxsein M, Kanis J, Napoli N, Papapoulos S, et al. Subtrochanteric fractures after long-term treatment with bisphosphonates: a European society on clinical and economic aspects of osteoporosis and osteoarthritis, and international osteoporosis foundation working group report. Osteoporos Int 2011; 22(2):373-90.
  3. World Health Organization. WHO scientific group on the assessment of osteoporosis at primary health care level. Summary meeting report. Geneva: World Health Organization; 2004.
  4. Soltani M, Soltani S, Abrishami LH, Zeiaadini L, Ashkanifar M. The analysis of relation between physical activity level with paratormone and calcitonin in middle aged women's. Biol Forum 2015; 7(2):142-7.
  5. Esmaili H, Alimi R, Javanrouh N, Azizi H, Vahid Roudsari F. Age at menopause and associated factors in middle-aged women in Mashhad city, 2010-2011. Iran J Obstet Gynecol Infertil 2013; 15(36):1-7. (Persian).
  6. Shabani R, Yosefizad L, Fallah F. Effects of eight weeks of endurance-resistance training on some inflammatory markers and cardiovascular endurance in sedentary postmenopausal women. Iran J Obstet Gynecol Infertil 2017; 20(1):23-30. (Persian).
  7. Mödder UI, Clowes JA, Hoey K, Peterson JM, McCready L, Oursler MJ, et al. Regulation of circulating sclerostin levels by sex steroids in women and in men. J Bone Miner Res 2011; 26(1):27-34.
  8. Lapauw B, Vandewalle S, Taes Y, Goemaere S, Zmierczak H, Collette J, et al. Serum sclerostin levels in men with idiopathic osteoporosis. Eur J Endocrinol 2013; 168(4):615-20.
  9. Izquierdo M, Häkkinen K, Ibanez J, Garrues M, Anton A, Zuniga A, et al. Effects of strength training on muscle power and serum hormones in middle-aged and older men. J Appl Physiol 2001; 90(4):1497-507.
  10. Simon D, Preziosi P, Barrett-Connor E, Roger M, Saint-Paul M, Nahoul K, et al. Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study. Diabetologia 1992; 35(2):173-7.
  11. Watkins ES. The estrogen elixir: a history of hormone replacement therapy in America. Maryland: JHU Press; 2007.
  12. Mohammadsani K. Examination amount of calcitonin and parathyroid hormones on women before and after postmenopausal and it’s relation with osteoprosis. J Med Sci Coll Gonabad 2001; 4:19-25.
  13. Rong H, Ji H, Tsai JA, Pernow Y, Bucht E. Calcitonin-suppressed expression of parathyroid hormone-related protein in breast cancer cells. Biochem Biophys Res Commun 1999; 265(1):260-4.
  14. Schipani E, Kruse K, Juppner H. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 1995; 268(5207):98-100.
  15. Calvi LM, Sims NA, Hunzelman JL, Knight MC, Giovannetti A, Saxton JM, et al. Activated parathyroid hormone/parathyroid hormone–related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J Clin Invest 2001; 107(3):277-86.
  16. Woitge HW, Friedmann B, Suttner S, Farahmand I, Müller M, Schmidt-Gayk H, et al. Changes in bone turnover induced by aerobic and anaerobic exercise in young males. J Bone Miner Res 1998; 13(12):1797-804.
  17. Tosun A, Bölükbaşı N, Çıngı E, Beyazova M, Ünlü M. Acute effects of a single session of aerobic exercise with or without weight-lifting on bone turnover in healthy young women. Mod Rheumatol 2006; 16(5):300-4.
  18. Meier C, Seibel MJ, Kraenzlin ME. Use of bone turnover markers in the real world: are we there yet? J Bone Miner Res 2009; 24(3):386-8.
  19. Garnero P, Delmas PD. Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J Clin Endocrinol Metab 1993; 77(4):1046-53.
  20. Beshgetoor D, Nichols JF, Rego I. Effect of training mode and calcium intake on bone mineral density in female master cyclists, runners, and non-athletes. Int J Sport Nutr Exerc Metab 2000; 10(3):290-301.
  21. Duncan CS, Blimkie CJ, Kemp A, Higgs W, Cowell CT, Woodhead H, et al. Mid-femur geometry and biomechanical properties in 15-to 18-yr-old female athletes. Med Sci Sports Exerc 2002; 34(4):673-81.
  22. Thorsen K, Kristoffersson A, Hultdin J, Lorentzon R. Effects of moderate endurance exercise on calcium, parathyroid hormone, and markers of bone metabolism in young women. Calcif Tissue Int 1997; 60(1):16-20.
  23. Ay A, Yurtkuran M. Evaluation of hormonal response and ultrasonic changes in the heel bone by aquatic exercise in sedentary postmenopausal women. Am J Phys Med Rehabil 2003; 82(12):942-9.
  24. Moazami M, Jamali FS. The effect of 6-months aerobic exercises on bone-specific alkaline phosphatase and parathyroid hormone in obese inactive woman. J Sport Biomotor Sci 2014; 10(2):71-9.
  25. Bemben DA, Sharma-Ghimire P, Chen Z, Kim E, Kim D, Bemben M. Effects of whole-body vibration on acute bone turnover marker responses to resistance exercise in young men. J Musculoskelet Neuronal Interact 2015; 15(1):23-31.
  26. Alp A. Effects of aerobic exercise on bone specific alkaline phosphatase and urinary CTX levels in premenopausal women. Turkish J Physical Med Rehabil 2013; 59(4):310-3.
  27. Sternfeld B, Ainsworth BE, Quesenberry CP. Physical activity patterns in a diverse population of women. Prev Med 1999; 28(3):313-23.
  28. Acevedo EO, Starks MA. Exercise testing and prescription lab manual. Canada: Human Kinetics; 2003.
  29. Ghahremani Moghadam M. Effect of aerobic training for 8 weeks on c-reactive protein, uric acid and total bilirubin in sedentary elderly women. Horizon Med Sci 2015; 21(2):81-9.
  30. Emami H, Rahnama N, Nuri R, Damirchi A, Rahmani-Nia F, Afshar-Nejad T. Effect of combination exercise training on sex hormone binding globulin in postmenopausal women with breast cancer. Gazzetta Med Italian 2012; 171(5):639-51.
  31. McCaulley GO, McBride JM, Cormie P, Hudson MB, Nuzzo JL, Quindry JC, et al. Acute hormonal and neuromuscular responses to hypertrophy, strength and power type resistance exercise. Eur J Appl Physiol 2009; 105(5):695-704.
  32. Silveira LC, Tezini GC, Schujmann DS, Porto JM, Rossi BR, Souza HC. Comparison of the effects of aerobic and resistance training on cardiac autonomic adaptations in ovariectomized rats. Auton Neurosci 2011; 162(1-2):35-41.
  33. Souster MJ. The effect of high-intensity resistance training on the hormonal and strength responses in healthy elderly males. [Master Thesis]. Canada: University of Alberta; 2000.
  34. Ebrahim K, Rezaei Sahraei A. Effect of eight weeks of aerobic and progressive exercises on changes of estrogen hormone and effective factors on bone mass in menopaused sedentary women. Iran J Endocrinol Metab 2010; 12(4):401-8.
  35. Salesi M, Khoshneshin Ghashghaee Z, Daryanoosh F, Tahmasebi S, Taleie A. The effect of eight weeks aerobic exercise on cardiovascular and hormonal risk factors in breast cancer patients. Razi J Med Sci 2015; 22(131):35-43.
  36. Aldahr MH. Bone mineral status response to aerobic versus resistance exercise training in postmenopausal women. World Appl Sci J 2012; 16(6):806-13.
  37. Lin LL, Hsieh SS. Effects of strength and endurance exercise on calcium-regulating hormones between different levels of physical activity. J Mechan Med Biol 2005; 5(2):267-75.
  38. Alghadir AH, Aly FA, Gabr SA. Effect of moderate aerobic training on bone metabolism indices among adult humans. Pakistan J Med Sci 2014; 30(4):840-4.
  39. Townsend R, Elliott-Sale KJ, Jessica Pinto A, Thomas C, Scott JP, Currell K, et al. Parathyroid hormone secretion is controlled by both ionised calcium and phosphate during exercise and recovery in men. J Clin Endocrinol Metab 2016; 101(8):3231-9.
  40. Takada H, Washino K, Hanai T, Iwata H. Response of parathyroid hormone to exercise and bone mineral density in adolescent female athletes. Environ Health Prev Med 1998; 2(4):161-6.
  41. Bellew JW, Gehrig L. A comparison of bone mineral density in adolescent female swimmers, soccer players, and weight lifters. Pediatr Phys Ther 2006; 18(1):19-22.
  42. Colletti LA, Edwards J, Gordon L, Shary J, Bell NH. The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men. Calcif Tissue Int 1989; 45(1):12-4.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 20, Issue 7
September 2017
Pages 8-17