بررسی اثر لیزر و نور شدید پالسی در درمان هیرسوتیسم در زنان مبتلا به سندرم تخمدان پلی‌کیستیک: مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 دکترای بهداشت باروری، مرکز تحقیقات اندوکرینولوژی تولید مثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 استاد، مرکز تحقیقات اندوکرینولوژی تولید مثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: در طی دهه‌های اخیر لیزردرمانی یکی از روش‌های محبوب در درمان هیرسوتیسم در افراد مبتلا به سندرم تخمدان پلی‌کیستیک بوده است. مطالعه حاضر با هدف تعیین اثر درمانی لیزر بر هیرسوتیسم در زنان مبتلا به سندرم تخمدان پلی‌کیستیک به‌صورت مرور سیستماتیک انجام شد.
روش‌کار: در این مطالعه جستجوی مطالعات تجربی و نیمه‌تجربی فارسی و انگلیسی در پایگاه‌های PubMed، Scopus، Web of Science،Cochrane library ، Magiran، SID،IranDoc  در ماه جولای 2020 انجام شد. جستجو با استفاده از کلید واژه‌های فارسی سندرم تخمدان پلی‌کیستیک، هیرسوتیسم، لیزر، درمان، مو و کلید واژه‌های لاتین مرتبط انجام شد. پیامد اصلی مورد بررسی شامل: اثر مداخله بر کاهش موها، مدت زمان کاهش موها، مدت زمان رشد موهای جدید و عوارض جانبی لیزر درمانی بود.
یافته‌ها: پس از جستجوی پیشرفته، 11 مقاله (638 شرکت‌کننده) دارای معیارهای ورود بودند. نوع پوست شرکت‌کنندگان بر اساس معیار فیتزپاتریک بود. در اکثر مطالعات دستگاه لیزر الکساندیرت مورد استفاده قرار گرفته بود. مدت زمان درمان در مطالعات حداکثر 6 ماه با فواصل درمانی 6-4 هفته بود. پیامد اصلی مورد بررسی شامل: کاهش معنادار تعداد مو و شدت موهای زائد، افزایش میانگین زمان رشد موهای جدید، میزان انرژی در بازه 50-10 ژول بر سانتی‌متر‌ مربع و مدت زمان 50-20 میلی‌ثانیه و عوارض شامل هیپرپیگمانتاسیون و اریتم و درد بود.
نتیجه‌گیری: یافته‌ها حاکی از تأثیر فناوری‌های مبتنی بر نور بر انواع مختلف پیامدهای مرتبط با درمان هیرسوتیسم در بیماران مبتلا به سندرم تخمدان پلی‌کیستیک می‌باشد، اما هنوز اتفاق نظر در مورد مناسب‌ترین نوع لیزر، فلوئنس و تعداد جلسات درمانی وجود ندارد. مطالعات کارآزمایی بالینی گسترده‌ای جهت تدوین دستورالعمل بالینی نیاز می‌باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of Laser and Intense Pulsed Light in treatment of hirsutism in women with polycystic ovary syndrome (PCOS): A systematic review

نویسندگان [English]

  • Marzieh Saei Ghare Naz 1
  • Fahimeh Ramezani Tehrani 2
1 PhD of Reproductive Health, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Professor, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: During recent decades, laser therapy has been one of the most popular methods in treatment of hirsutism in women with polycystic ovary syndrome (PCOS). This study was performed with aim to determine the therapeutic effect of laser on hirsutism in women with PCOS as a systematic review.
Methods: The search process of experimental and semi-experimental studies (Persian and English language) was performed in databases including PubMed, Scopus, Web of Science, Cochrane library, Magiran, SID, and IranDoc up to July 2020. The search was performed using the keywords of polycystic ovary syndrome, hirsutism, laser, treatment, hair, and the related latin keywords. The main outcomes were the effect of interventions on hair loss, hair loss duration, the duration of new hair growth, and the side effects of laser treatment.
Results: After the advanced search, 11 articles (638 participants) had inclusion criteria. The skin type of the participants was based on Fitzpatrick scale. The majority of studies used the Alexandrite laser device. The duration of treatment in the studies was a maximum of 6 months with treatment intervals of 4 to 6 weeks. The main outcomes of this study included: significant reduction in the number of hairs and the intensity of excess hair, an increase in the mean growth time of new hair, energy levels in the range of 10 to 50 j/cm2 and duration of 20-50 milliseconds. The complications included hyperpigmentation, erythema, and pain.
Conclusion: The findings indicated the impact of light-based technologies on different types of outcomes associated with the treatment of hirsutism in women with PCOS, but due to the limitations, there is no consensus on the most appropriate type of laser, fluorescence, and the number of treatment sessions. Greater clinical trial studies are needed to develop the clinical guidelines.

کلیدواژه‌ها [English]

  • Polycystic Ovary Syndrome
  • Laser
  • Hirsutism
  • Treatment
  • Systematic Review

مراجع

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مجله زنان، مامایی و نازایی ایران
دوره 23، شماره 10
دی 1399
صفحه 96-108

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