بررسی تأثیر کپسول گیاه بومادران بر میزان و مدت خونریزی قاعدگی در زنان مبتلا به منوراژی

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد مامایی، سازمان تأمین اجتماعی، اصفهان، ایران.

2 دانشیار گروه مامایی و بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 استاد گروه فارماکوگنوزی، مرکز تحقیقات علوم دارویی، دانشکده داروسازی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

4 دانشیار گروه آمار زیستی، مرکز تحقیقات بیماری‌های گوارش و کبد، پژوهشکده بیماری‌های گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: منوراژی، یکی از شایع‌ترین مشکلات ژنیکولوژیک و یکی از علل کم‌خونی فقر آهن در زنان می­باشد. با توجه به فقدان پژوهش در این زمینه، مطالعه حاضر با هدف تعیین اثر عصاره هیدروالکلی گیاه بومادران بر منوراژی انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی، شاهددار و سه‌سوکور در سال 1395 بر روی 120 نفر از زنان مبتلا به منوراژی مراجعه‌کننده به مرکز درمانی ولیعصر وابسته به دانشگاه علوم پزشکی تهران انجام شد. ابزار مطالعه شامل فرم اطلاعاتی، چارت ارزیابی میزان خونریزی پکتوریال (PBAC)، وزنه و متر بود. پس از تأیید منوراژی در سیکل پایه، گروه مداخله با 150‌ میلی‌گرم کپسول بومادران و 500 میلی‌گرم کپسول مفنامیک‌اسید و گروه دارونما با کپسول دارونمای بومادران و مفنامیک‌اسید هر 8 ساعت در 7 روز سیکل قاعدگی، طی 2 ماه متوالی درمان و در سیکل بعدی با چارت PBAC پیگیری شدند. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه19) و آزمون‌های آماری تی‌مستقل، تی‌زوجی، آنالیز واریانس با اندازه‌گیری‌های مکرر، فریدمن، ویلکاکسون، من‌ویتنی، فیشر و کای‌اسکوئر انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: مدت و میزان خونریزی قاعدگی در هر دو گروه کاهش یافت (001/0>p). کاهش میزان و مدت خونریزی (001/0>p) در گروه بومادران بیشتر بود. هرچند مدت و میزان خونریزی طی دوره پیگیری پس از درمان در هر دو گروه نسبت به دوره مداخله افزایش یافت (001/0>p)، ولی نسبت به قبل از مداخله کمتر بود (001/0>p).
نتیجه‌گیری: با توجه به تأثیر بومادران در کاهش میزان خونریزی قاعدگی، می‌توان از بومادران در درمان منوراژی استفاده نمود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of Achillea millefolium on the intensity and duration of menstrual bleeding of women with menorrhagia

نویسندگان [English]

  • Farzaneh Ebrahimi Varzaneh 1
  • Fatemeh Nahidi 2
  • Faraz Mojab 3
  • Mohamad Amin Pourhoseingholi 4
1 M.Sc. in Midwifery, Social Security Organization, Esfahan, Iran.
2 Associate Professor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Professor, Department of Pharmacognosy, Pharmaceutical Sciences Research Center, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Associate Professor, Department of Biostatistics, Gastroenterology and Liver Diseases Research Center, Research Institute Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Menorrhagia is one of the common gynecological problems and one of the reasons for iron deficiency anemia in women. Regarding to the lack of researches in this field, this study was performed with aim to determine the effect of hydro alcoholic extract of Achillea Milefolium (AM) on Menorrhagia.
Methods: This triple-blind randomized controlled clinical trial was performed on 120 women with Menorrhagia referred to Valiasr medical center of Tehran University of Medical Sciences in 2016. Study instruments were demographic form, pictorial blood loss assessment chart (PBAC), weight and meter. After confirming Menorrhagia in basic cycle, the intervention group was treated with 150mg AM capsule and 500mg Mefenamic-acid capsules and the placebo group was treated with AM placebo capsules and Mefenamic-acid capsules every eight hours in seven days of menstruation for two consecutive months. In the next cycle, they were followed-up by the PBAC. Data were analyzed by SPSS software (version 19) and independent t-test, paired t-test, Repeated measurement variance analysis, Friedman, Wilcoxon, Mann-Whitney, Fisher and Chi-square tests (p<0.05).
Results: The intensity and duration of menstrual bleeding significantly decreased in both groups (p<0.001). Reduction of intensity and duration of bleeding was significantly higher in the AM group (p<0.001) and duration of bleeding in intervention group was insignificantly higher (p>0.001). Although, intensity and duration of bleeding in both groups increased after the intervention compared with intervention period (p<0.001), but was lower compared with before the intervention (p<0.001).
Conclusion: According to the effect of AM on reduction of menstrual bleeding, AM can be used in treatment of Menorrhagia.

کلیدواژه‌ها [English]

  • Achillea Milefolium
  • Mefenamic-acid
  • Menorrhagia

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مجله زنان، مامایی و نازایی ایران
دوره 23، شماره 2
اردیبهشت 1399
صفحه 67-77

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