The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Investigating the effect of ferrous sulfate on thyroid function in pregnant women with acquired hypothyroidism during the second trimester of pregnancy in Urmia Kowsar Hospital

Articles in Press

Document Type : Original Article

Authors
Somayeh Ghasemzadeh
Mobina Porghahramani
Javad Rasouli
Fatemeh Bahadori
Clinical Research Development Unit of Kowsar Women’s Medical Center, Urmia University of Medical Sciences, Urmia, Iran
10.22038/ijogi.2026.86918.6387
Abstract
Introduction: Pregnant women are more susceptible to iron deficiency anemia, and iron deficiency anemia is commonly observed in individuals with hypothyroidism. This study aimed to investigate the effect of ferrous sulfate on thyroid function in pregnant women with acquired hypothyroidism during the second trimester at the Kosar Women’s Hospital in Urmia.

Methodology: In this randomized clinical trial, 48 pregnant women with acquired hypothyroidism in their second trimester, referred to Kosar Hospital in Urmia, were randomly divided into two groups of 24. The intervention group received two daily tablets of ferrous sulfate containing 50 mg of elemental iron, while the control group received two placebo tablets. After three months, serum levels of ferritin, iron, and TSH were evaluated in both groups.

Findings: The mean age of the participants was 30.90 ± 11.24 years. The mean serum ferritin and iron levels in the intervention group were significantly higher than those in the control group (37.22 vs. 14.96, P < 0.001; 89.35 vs. 24, P < 0.001, respectively). Additionally, the mean TSH levels showed a statistically significant difference between the control and intervention groups (6.29 vs. 16.41, P < 0.001).

Conclusion: The findings indicated that the use of ferrous sulfate could influence thyroid function in pregnant women with acquired hypothyroidism during pregnancy. Further research could provide a more detailed insight.
Keywords
Thyroid
Ferritin
Iron
Pregnancy
Subjects
The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 08 June 2026