The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Efficacy of Solifenacin Succinate in Treatment of Mixed Urinary Incontinence

Document Type : Original Article

Authors
Soodabeh Darvish 1
Nastaran Teymoorianfard 2
1 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2026.88676.6456
Abstract
Introduction: Given the prevalence and high physical and psychological complications of urinary incontinence, as well as the need to identify more effective treatments, this study was conducted with aim to determine the efficacy of Solifenacin succinate in treatment of mixed urinary incontinence.
Methods: In this randomized controlled clinical trial, 200 women with mixed urinary incontinence who visited Taleghani Hospital in Tehran between 2022 and 2024 were selected based on inclusion criteria and through convenience sampling. They were randomly assigned using block randomization into two groups: the intervention group (n=100, 5 mg oral solifenacin succinate once daily for three months) and the placebo group (n=100). The severity of urinary incontinence was assessed using the standardized QUID questionnaire once before the study and then at 1.5 and 3 months after the study, with comparisons made between the two groups. Data analysis was performed using SPSS statistical software (version 23) and the paired t-test, Mann-Whitney, Chi-square, and Fisher's exact tests. P<0.05 was considered significant.
Results: The QUID scores decreased significantly more in the intervention group compared to the control group at 1.5 months post-study (-8.47 ± 2.94 vs. -0.88 ± 1.42, p<0.001) and at 3 months post-study (-11.87 ± 3.04 vs. -5.70 ± 4.24, p<0.001). In the intervention group compared to the control group, the QUID questionnaire scores were significantly lower at 1.5 months (6.65 ± 1.08 vs. 14.80 ± 2.52, p<0.001) and at 3 months post-study (3.25 ± 1.11 vs. 9.98 ± 4.34, p<0.001).
Conclusion: It appears that Solifenacin succinate is an effective medication for treatment of mixed urinary incontinence.
Keywords
Urinary Incontinence
Solifenacin Succinate
Mixed Urinary Incontinence
Subjects
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 29, Issue 1
March 2026
Pages 9-17