نوع مقاله : اصیل پژوهشی
نویسندگان
1 گروه آموزشی مامایی، دانشکده علوم پزشکی گناباد، گناباد، ایران
2 استادیار گروه مامایی، مرکز تحقیقات توسعه اجتماعی و ارتقاء سلامت، دانشکده پزشکی، دانشگاه علوم پزشکی گناباد، گناباد، ایران
3 مرکز تحقیقات توسعه اجتماعی و ارتقای سلامت، دانشگاه علوم پزشکی گناباد، گناباد، ایران
4 جراح و متخصص زنان، زایمان و نازایی، دانشگاه علوم پزشکی شیراز، شیراز، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Polycystic ovary syndrome (PCOS) is the most common cause of ovulation disorder in women of childbearing age, with a prevalence of 20% reported worldwide.
Methods: This three-blind clinical trial study was performed on 60 infertile women with polycystic ovary syndrome in 2021. Subjects were randomly assigned to the intervention (Vitex Agnus-Castus) and control (placebo) groups. The intervention group used two Vitex Agnus-Castus tablets and one Folic Acid daily and the control group used two placebo tablets and one Folic Acid tablet for two months. In the second month, in addition to the mentioned drugs, all participants from the third to the seventh day of menstruation used 2.5 mg Letrozole for five days and on the 13 day of the cycle, they referred for ultrasound.
Results: After the intervention, the mean number of follicles in the Vitex Agnus-Castus group was significantly higher than the control group (2.73 ±0.90 vs. 2.06 ± 0.98, P = 0.008). Also in the Vitex Agnus-Castus group, the mean size of follicles was significantly higher than the control group (19.71± 1.98 vs. 17.73 ± 3.44, P = 0.009).
Conclusion: The results of the present study indicate that the use of Vitex Agnus-Castus tablets with Letrozole in comparison with Letrozole alone can improve the quality of follicles.
کلیدواژه‌ها [English]
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