The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

The changes of some total antioxidant capacity and lipid peroxidation markers following the combined with high intensity interval training in sedentary postmenopausal women

Document Type : Original Article

Authors
Sara Akhtegan 1
Sirvan Atashak 2
Reza Roshdi Bonab 3
1 M.Sc. Student of Exercise Physiology, Bonab Branch, Islamic Azad University, Bonab, Iran.
2 Associate professor, Department of Exercise Physiology, Mahabad Branch, Islamic Azad University, Mahabad, Iran.
3 Assistant professor, Department of Exercise Physiology, Bonab Branch, Islamic Azad University, Bonab, Iran.
10.22038/ijogi.2022.20045
Abstract
Introduction: It has been proposed that regular exercise training is effective methods to reduce the levels of oxidative stress and its disorders. Therefore, this study was performed aimed to evaluate the changes of some total antioxidant capacity and lipid peroxidation markers following the combined with high intensity interval training in sedentary postmenopausal women.
Methods: This semi-experimental study was performed  in 2020 on 45 sedentary menopause women  in Bonab city. The subjects were randomly assigned to 3 groups: high-intensity interval training, combined exercise training and control. Exercise training programs were done in 3 nonconsecutive days for twelve week. Blood samples were collected 48 hours before and after exercise training and the level of malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. Data were analyzed by SPSS software (version 24) and correlated t-test and Covariance of analysis (ANCOVA) test. P<0.05 was considered statistically significant.
Results: There were no differences between three groups in the physical physiological indices at the beginning of the study (p>0.05). The twelve week of both type of exercise training methods significantly decreased the MDA and significantly increased the TAC levels in sedentary menopause women  (p<0.05). While, there were no significant differences in these indicators during the study period in the control group. However, there were no significant difference between two exercise training methods (p>0.05). Moreover, significant correlation was observed between the changes of this markers with the changes in some of body composition indices in training groups (p<0.05).
Conclusion: Performing 12 weeks of combined and high intensity interval training can lead to increase of total antioxidant capacity and decrease lipid peroxidation indicators, therefore, it can be recommend these exercises training methods for postmenopausal women to improve oxidative stress.
Keywords
Combined training
High intensity interval training
Malondialdehyde
Postmenopausal women
Total antioxidant capacity
  1. Firozeh HE, Mehide A, Azizi F, MIran PM. The effect of menopause on anthropometric changes and risk factors for cardiovascular disease. Iranian Journal of Diabetes and Lipid Disorders 2011; 10(6):636-46. eng.
  2. Bourgonje AR, Abdulle AE, Al-Rawas AM, Al-Maqbali M, Al-Saleh M, Enriquez MB, et al. Systemic oxidative stress is increased in postmenopausal women and independently associates with homocysteine levels. International journal of molecular sciences 2020; 21(1):314.
  3. Montoya-Estrada A, Velázquez-Yescas KG, Veruete-Bedolla DB, Ruiz-Herrera JD, Villarreal-Barranca A, Romo-Yañez J, et al. Parameters of oxidative stress in reproductive and postmenopausal Mexican women. International journal of environmental research and public health 2020; 17(5):1492.
  4. Doshi SB, Agarwal A. The role of oxidative stress in menopause. Journal of mid-life health 2013; 4(3):140.
  5. Ghorbanian B, Saberi Y, Shokrolahi F, Mohamadi H. Effect of an Incremental Interval Endurance Rope-Training Program on Antioxidant Biomarkers and Oxidative Stress in Non-Active Women. Scientific Journal of Nursing, Midwifery and Paramedical Faculty 2018; 4(1):29-40.
  6. Zovari F, Parsian H, Bijani A, Moslemnezhad A, Shirzad A. Evaluation of salivary and serum total antioxidant capacity and lipid peroxidation in postmenopausal women. International Journal of Dentistry 2020; 2020.
  7. Moldogazieva NT, Mokhosoev IM, Mel’nikova TI, Porozov YB, Terentiev AA. Oxidative stress and advanced lipoxidation and glycation end products (ALEs and AGEs) in aging and age-related diseases. Oxidative medicine and cellular longevity 2019; 2019.
  8. Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radical Biology and Medicine 2008; 44(2):153-9.
  9. Friedenreich CM, Pialoux V, Wang Q, Shaw E, Brenner DR, Waltz X, Conroy SM, Johnson R, Woolcott CG, Poulin MJ, Courneya KS. Effects of exercise on markers of oxidative stress: an Ancillary analysis of the Alberta Physical Activity and Breast Cancer Prevention Trial. BMJ Open Sport & Exercise Medicine. 2016 Oct 1;2(1):e000171.
  10. Poblete Aro CE, Russell Guzmán JA, Soto Muñoz ME, Villegas González BE. Effects of high intensity interval training versus moderate intensity continuous training on the reduction of oxidative stress in type 2 diabetic adult patients: CAT. Medwave 2015; 15(07).
  11. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise; 2011.
  12. Shimojo GL, Silva Dias DD, Malfitano C, Sanches IC, Llesuy S, Ulloa L, et al. Combined aerobic and resistance exercise training improve hypertension associated with menopause. Frontiers in physiology 2018; 9:1471.
  13. Salehi I, Zarrinkalam E, Mirzaei F, Oshaghi EA, Ranjbar K, Asl SS. Effects of resistance, endurance, and concurrent exercise on oxidative stress markers and the histological changes of intestine after morphine withdrawal in rats. Avicenna Journal of Medical Biochemistry 2018; 6(2):44-9.
  14. Yoon JR, Ha GC, Ko KJ, Kang SJ. Effects of exercise type on estrogen, tumor markers, immune function, antioxidant function, and physical fitness in postmenopausal obese women. Journal of exercise rehabilitation 2018; 14(6):1032.
  15. Rohani H, Safarimosavi S, Mohebbi H. The Comparison of 12 Weeks Continuous Training at Fatmax and Anaerobic Threshold Intensities and High Intensity Interval Training on Antioxidant Enzymes and Lipid Peroxidation Index in Pre-diabetic Patients. Medical Journal of Tabriz University of Medical Sciences 2020; 42(2):168-76.
  16. Azamian Jazi A, Shokouhi R. The effect of an eight week combined exercise training on oxidative stress and lipid peroxidation in postmenopausal women with type 2 diabetes. SSU_Journals 2016; 24(8):667-78.
  17. Jackson AS, Pollock ML. Practical assessment of body composition. The Physician and sportsmedicine 1985; 13(5):76-90.
  18. Afrasyabi S, Marandi SM, Kargarfard M. The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight. Journal of Diabetes & Metabolic Disorders 2019; 18(1):107-17.
  19. Kargarfard M, Shariat A, Shaw I, Haddadi P, Shaw BS. Effects of resistance and aerobic exercise training or education associated with a dietetic program on visfatin concentrations and body composition in overweight and obese women. Asian Journal of Sports Medicine 2017; 8(4).
  20. Farzanegi P, Habibian M, Kaftari A. Effect of 6-weeks aerobic exercise training on oxidative stress and enzymatic antioxidants in postmenopausal women with hypertension: Case Study. Journal of Mazandaran University of Medical Sciences 2014; 23(108):134-6.
  21. Conti FF, Brito JD, Bernardes N, Dias DD, Malfitano C, Morris M, et al. Positive effect of combined exercise training in a model of metabolic syndrome and menopause: autonomic, inflammatory, and oxidative stress evaluations. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2015; 309(12):R1532-9.
  22. Azizbeigi K, Stannard SR, Atashak S, Haghighi MM. Antioxidant enzymes and oxidative stress adaptation to exercise training: Comparison of endurance, resistance, and concurrent training in untrained males. Journal of Exercise Science & Fitness 2014; 12(1):1-6.
  23. Powers SK, Duarte J, Kavazis AN, Talbert EE. Reactive oxygen species are signalling molecules for skeletal muscle adaptation. Experimental physiology 2010; 95(1):1-9.
  24. Jamka M, Bogdański P, Krzyżanowska-Jankowska P, Miśkiewicz-Chotnicka A, Karolkiewicz J, Duś-Żuchowska M, et al. Endurance training depletes antioxidant system but does not affect endothelial functions in women with abdominal obesity: a randomized trial with a comparison to endurance-strength training. Journal of clinical medicine 2021; 10(8):1639.
  25. Sahhaf F, Nazari M, Dorosti A. Effect of eight weeks intermittent exercise training on oxidative stress indices in women with preterm labor after coronary artery bypass graft surgery (CABG): randomized clinical trial. Iran J Obstet Gynecol Infertil 2020; 23(3):1-8.
  26. Emadi S, Azamian Jazi A, Hemati S. Effect of 6 weeks of low-volume high-intensity interval training on antioxidant defense and aerobic power in female survivors of breast cancer. medical journal of mashhad university of medical sciences 2018; 60(6):779-91.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 24, Issue 13
February 2022
Pages 70-79