مرور نظام‌مند عصاره چای سبز (سینکاتچین): یک درمان گیاهی برای زگیل تناسلی خارجی

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 استادیار گروه مامایی، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: زگیل‌های تناسلی خارجی ناشی از ویروس پاپیلوم انسانی، شایع‌ترین عفونت منتقل شونده جنسی هستند. گزینه‌های درمانی زیادی برای زگیل‌های تناسلی وجود دارند که می‌توانند به پزشک کمک کنند، اما بسیاری از بیماران تمایل دارند درمانی را انتخاب کنند که در خانه استفاده شود. عصاره چای سبز (سینکاتچین) یک درمان گیاهی برای زگیل ژنیتال خارجی است که توسط بیمار قابل استفاده است. مطالعه حاضر با هدف مرور نظام‌مند بر مطالعات مرتبط با چای سبز در درمان زگیل تناسلی انجام شد.
روش‌کار: در این مطالعه مروری، مقالات مربوطه در پایگاه‌های اطلاعاتی Pubmed، Scopus، Siencedirect، Proquest و Google Scholar در بازه زمانی سال 2019-2000 با ترکیبات مختلف کلمات کلیدی چای سبز و زگیل تناسلی انتخاب شدند. از مجموع 21 مقاله، 9 مقاله مرتبط با هدف انتخاب شدند.
یافته‌ها: از میان مطالعات بررسی شده، 9 مطالعه در دو گروه پلاسبو و پماد سینکاتچین 15% و 10% مورد تجزیه و تحلیل قرار گرفتند. در همه مطالعات در خصوص بهبودی کامل همه زگیل‌های ژنیتال، اختلاف آماری معنی‌داری بین پماد 15% و 10% سینکاتچین وجود نداشت، اما این اختلاف در مقایسه با پلاسبو معنی‌دار بود. شمار کمتری از عود زگیل پس از پایان درمان در گروه سینکاتچین نسبت به پلاسبو مشاهده شد.
نتیجه‌گیری: عصاره چای سبز دارویی اثربخش و ایمن، با عوارض جانبی و میزان عود کمتر در درمان زگیل تناسلی شناخته شده است.

کلیدواژه‌ها

عنوان مقاله [English]

Green Tea Extract (Syncatchin) an herbal remedy for external genital warts (Systematic Review)

نویسندگان [English]

  • Zohre Mousavi 1
  • Nahid Golmakani 2
1 M.Sc. of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant Professor, Department of Midwifery, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: External genital warts caused by human papillomavirus are the most common sexually transmitted infections. There are many treatment options for genital warts that can help the doctor, but many patients tend to use a home-based treatment. Green tea extract (syncatchin) is an herbal remedy for external genital warts that can be used by the patient. This study was performed with aim to systematic review the studies related to green tea in the treatment of genital warts.
Methods: In this review study, the relevant articles were selected in the databases of Pubmed, Scopus, Siencedirect, Proquest, and Google Scholar in 2000-2019 with different combinations of "green tea" and "genital wart" keywords. From a total of 21 articles, 9 articles related to the purpose were selected.
Results: Among the studied articles, 9 studies were analyzed in two groups of placebo and syncatin ointment 15% and 10%. In all studies about complete recovery of all genital warts, there was no statistically significant difference between 15% and 10% syncatchin ointment, but this difference was significant compared to placebo group. There was less number of warts recurrences at the end of treatment in the Sincatchin group compared to placebo group.
Conclusion: Green tea extract is known as an effective and safe drug with less side effects and recurrence rate in the treatment of genital warts.

کلیدواژه‌ها [English]

  • Genital Warts
  • Green Tea Extract
  • Polyphenol E
  • Syncatchin

مراجع

  1. Layegh P, Pezeshkpour F, EMAM GT, Shakeri MT. Cryotherapy versus podophyllin in the treatment of genital wart. Iran J Obstet Gynecol Infertil 2007; 10(2):133-8.
  2. Tatti S, Swinehart JM, Thielert C, Tawfik H, Mescheder A, Beutner KR. Sinecatechins, a defined green tea extract, in the treatment of external anogenital warts: a randomized controlled trial. Obstetrics & Gynecology 2008; 111(6):1371-9.
  3. Gupta AK, Daigle D. Sinecatechins 10% ointment: a green tea extract for the treatment of external genital warts. Skin therapy letter 2015; 20(1):6-8.
  4. Akhavan S, Mousavi A, Modaresgilani M, Alibakhshi A. Genital Warts. Journal of Obstetrics, Gynecology and Cancer Research (JOGCR) 2017; 2(1).
  5. Ryan KJ. Kistner's gynecology and women's health. Mosby Incorporated; 1999.
  6. Schöfer H, Tatti S, Lynde CW, Skerlev M, Hercogová J, Rotaru M, et al. Sinecatechins and imiquimod as proactive sequential therapy of external genital and perianal warts in adults. International journal of STD & AIDS 2017; 28(14):1433-43.
  7. Malakouti J, Mirghafourvand M, Gorbani M, Salehi Poormehr H, Pourasad Shahrak S, Jafari Shabiri M. Incidence of Human Papilloma Virus (HPV) infection and its relevant factors among women referring to Alzahra Therapeutic-Educational Center of Tabriz, September 2013 to March 2014. Iran J Obstet Gynecol Infertil 2016; 18(185):16-22.
  8. Soori T, Hallaji Z, Noroozi-Nejad E. Genital warts in 250 Iranian patients and their high-risk sexual behaviors. Archives of Iranian medicine 2013; 16(9):518.
  9. Trottier H, Franco EL. The epidemiology of genital human papillomavirus infection. Vaccine 2006; 24:S4-15.
  10. Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's textbook of dermatology. 7nd ed. John Wiley & Sons; 2008.
  11. Berek JS. Berek & Novak's Gynecology. 14nd ed. Lippincott Williams & Wilkins; 2007.
  12. Shahali S, Amin M, Hassani MK, Yaghoobi R, Saki M. Effects of shallomin and podophyllin solution 25% for genital HPV warts in women: a randomized controlled trial. Journal of Acute Disease 2019; 8(3):118.
  13. Langley PC. A cost-effectiveness analysis of sinecatechins in the treatment of external genital warts. Journal of medical economics 2010; 13(1):1-7.
  14. Meltzer SM, Monk BJ, Tewari KS. Green tea catechins for treatment of external genital warts. American journal of obstetrics and gynecology 2009; 200(3):233-e1.
  15. Stockfleth E, Meyer T. The use of sinecatechins (polyphenon E) ointment for treatment of external genital warts. Expert opinion on biological therapy 2012; 12(6):783-93.
  16. Gross G, Meyer KG, Pres H, Thielert C, Tawfik H, Mescheder A. A randomized, double‐blind, four‐arm parallel‐group, placebo‐controlled Phase II/III study to investigate the clinical efficacy of two galenic formulations of Polyphenon® E in the treatment of external genital warts. Journal of the European Academy of Dermatology and Venereology 2007; 21(10):1404-12.
  17. Tatti S, Stockfleth E, Beutner KR, Tawfik H, Elsasser U, Weyrauch P, et al. Polyphenon E®: a new treatment for external anogenital warts. British Journal of Dermatology 2010; 162(1):176-84.
  18. World Health Organization. Human papillomavirus (HPV) and cervical cancer hwwimffe, accessed 14 November 2016).
  19. On SC, Linkner RV, Haddican M, Yaroshinsky A, Gagliotti M, Singer G, et al. A single-blinded randomized controlled study to assess the efficacy of twice daily application of sinecatechins 15% ointment when used sequentially with cryotherapy in the treatment of external genital warts. J Drugs Dermatol 2014; 13(11):1400-5.
  20. Ahn WS, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, et al. Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. European journal of cancer prevention 2003; 12(5):383-90.
  21. Stockfleth E, Meyer T. Sinecatechins (Polyphenon E) ointment for treatment of external genital warts and possible future indications. Expert opinion on biological therapy 2014; 14(7):1033-43.
  22. Tuong W, Walker L, Sivamani RK. Polyphenols as novel treatment options for dermatological diseases: A systematic review of clinical trials. Journal of Dermatological Treatment 2015; 26(4):381-8.
  23. Panelists GG, Taylor M, Berman B, Kaufmann M, Abramovits W, Zeichner J. Sinecatechins ointment, 15% for the treatment of external genital and perianal warts: proceedings of an expert panel roundtable meeting. The Journal of clinical and aesthetic dermatology 2016; 9(3 Suppl 1):S2.
  24. Lacey CJ, Goodall RL, Tennvall GR, Maw R, Kinghorn GR, Fisk PG, et al. Randomised controlled trial and economic evaluation of podophyllotoxin solution, podophyllotoxin cream, and podophyllin in the treatment of genital warts. Sexually Transmitted Infections 2003; 79(4):270-5.
  25. Juhl ME, Seferovic V, Antonijevic S, Krunic A. Combined treatment of anogenital HPV infection with cryodestruction, podophyllin 25% and post-ablation immunomodulation with sinecatechins 15% ointment–a retrospective analysis. International journal of STD & AIDS 2016; 27(12):1071-8.
  26. Khan N, Mukhtar H. Multitargeted therapy of cancer by green tea polyphenols. Cancer letters 2008; 269(2):269-80.
  27. Stockfleth E, Beti H, Orasan R, Grigorian F, Mescheder A, Tawfik H, et al. Topical Polyphenon® E in the treatment of external genital and perianal warts: a randomized controlled trial. British Journal of Dermatology 2008; 158(6):1329-38.
مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 4
تیر 1400
صفحه 100-107

فایل ها

هم رسانی

ارجاع به این مقاله

آمار