The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Comparative study of the role of zinc in the scar recovery after abdominal hysterectomy in women with and without cancer and its relation with anthropometric indices of women referred to Tabriz hospitals: A case-control study

Document Type : Original Article

Authors
Farshad Mahdavi 1
Mehdi Haghdoost 2
1 Assistant professor, Department of General Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Assistant Professor, Department of Infectious Diseases, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
10.22038/ijogi.2020.16285
Abstract
Introduction: It is possible that zinc levels in cancer patients are lower than normal people and this may prolong the treatment process of these patients. Therefore, the present study was performed with aim to compare the role of zinc in scar recovery after abdominal hysterectomy in women with and without cancer and its relation to anthropometric indices of women referring to Tabriz hospitals.
Methods: This case-control study was conducted in Tabriz hospitals with the participation of 84 women )after abdominal hysterectomy( in 2018. Demographic data, anthropometric indices, serum zinc level and scar recovery status (based on researcher-made questionnaire) of each patient were recorded after abdominal hysterectomy. Data were analyzed by SPSS software (version 20) and Pearson correlation coefficient, Chi-square and independent t-test. P<0.05 was considered statistically significant.
Results: Mean serum zinc level in cancer patients was 43.13±4.93 μg / dl and in those without cancer was 118.73 ± 11.42 μg / dl (P=0.009). The majority of patients with cancer (71.42% ) had a better-than-average period of wound healing, while the majority of patients without cancer (80.95%) were associated with normal healing (P=0.003). Significant positive correlation was found between zinc level only in weight index in cancer patients (r=0.112 , P=0.005) and positive relationships were seen in other indicators of cancer patients and non-cancer patients, but were not statistically significant.
Conclusion: Low levels of zinc lead to undesirable effects on timely recovery in cancer patients after abdominal hysterectomy compared to non-cancer ones.
Keywords
Cancer
Hysterectomy
Wound healing
Zinc
  1. Gol MK, Dadashzadeh M, Anvari HM. Design and Implementation of a Checklist for Prediction of Anesthesia-Induced Nausea and Vomiting in Candidate Patients for Mastectomy. International Journal of Women’s Health and Reproduction Sciences 2020; 8(1):90-94.
  2. Khanbabaei Gol M, Rezvani F, Ghavami Z, Mobaraki-Asl N. Prevalence of neuropathic pain and factors affecting sleep quality in women with breast cancer after radiotherapy. Iran J Obstet Gynecol Infertil 2019; 22(6):46-53.
  3. Montazer M, Hadadi Z, Ghavami Z, Khanbabaei Gol M. Relationship of Body Mass Index with Chronic Pain after Breast Surgery in Women with Breast Cancer. Iran J Obstet Gynecol Infertil 2019; 22(8):10-18.
  4. Sandberg EM, Twijnstra ARH, Driessen SRC, Jansen FW. Total laparoscopic hysterectomy versus vaginal hysterectomy: a systematic review and meta-analysis. J Minim Invasive Gynecol 2017; 24(2):206-217.e22.
  5. Khanbabaei Gol M, Aghamohammadi D. Effect of intravenous infusion of magnesium sulfate on opioid use and hemodynamic status after hysterectomy: double-blind clinical trial. Iran J Obstet Gynecol Infertil 2019; 22(7):32-38.
  6. Liu F, Pan Y, Liang Y, Zhang C, Deng Q, Li X, et al. The epidemiological profile of hysterectomy in rural Chinese women: a population-based study. BMJ open 2017; 7(6):e015351.
  7. Matsuhashi T, Nakanishi K, Hamano E, Kamoi S, Takeshita T. Laparoscopic repair of vaginal evisceration after abdominal hysterectomy for uterine corpus cancer: a case report and literature review. J Nippon Med Sch 2017; 84(2):90-95.
  8. Asher R, Obermair A, Janda M, Gebski V. Disease-free and survival outcomes for total laparoscopic hysterectomy compared with total abdominal hysterectomy in early-stage endometrial carcinoma: a meta-analysis. In J Gynecol Cancer 2018; 28(3):529-538.
  9. Andersen LL, Zobbe V, Ottesen B, Gluud C, Tabor A, Gimbel H, et al. Five‐year follow up of a randomised controlled trial comparing subtotal with total abdominal hysterectomy. BJOG 2015; 122(6):851-7.
  10. Mowers EL, Lim CS, Skinner B, Mahnert N, Kamdar N, Morgan DM, et al. Prevalence of endometriosis during abdominal or laparoscopic hysterectomy for chronic pelvic pain. Obstet Gynecol 2016; 127(6):1045-53.
  11. Colling KP, Glover JK, Statz CA, Geller MA, Beilman GJ. Abdominal hysterectomy: reduced risk of surgical site infection associated with robotic and laparoscopic technique. Surg Infect (Larchmt) 2015; 16(5):498-503.
  12. Meriwether KV, Antosh DD, Olivera CK, Kim-Fine S, Balk EM, Murphy M, et al. Uterine preservation vs hysterectomy in pelvic organ prolapse surgery: a systematic review with meta-analysis and clinical practice guidelines. Am J Obstet Gynecol 2018; 219(2):129-146.e2.
  13. Stanirowski PJ, Wnuk A, Cendrowski K, Sawicki W. Growth factors, silver dressings and negative pressure wound therapy in the management of hard-to-heal postoperative wounds in obstetrics and gynecology: a review. Arch Gynecol Obstet 2015; 292(4):757-75.
  14. Ismail A, Abushouk AI, Elmaraezy A, Menshawy A, Menshawy E, Ismail M, et al. Cutting electrocautery versus scalpel for surgical incisions: a systematic review and meta-analysis. J Surg Res 2017; 220:147-163.
  15. Woo KY, Beeckman D, Chakravarthy D. Management of moisture-associated skin damage: a scoping review. Adv Skin Wound Care 2017; 30(11):494-501.
  16. Dhaliwal S, Nguyen M, Vaughn AR, Notay M, Chambers CJ, Sivamani RK. Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence. Am J Clin Dermatol 2020; 21(1):21-39.
  17. Bogdan J, Pławińska-Czarnak J, Zarzyńska J. Nanoparticles of titanium and zinc oxides as novel agents in tumor treatment: a review. Nanoscale Res Lett 2017; 12(1):225.
  18. Jouybari L, Kiani F, Akbari A, Sanagoo A, Sayehmiri F, Aaseth J, et al. A meta-analysis of zinc levels in breast cancer. J Trace Elem Med Biol 2019; 56:90-99.
  19. Wu X, Tang J, Xie M. Serum and hair zinc levels in breast cancer: a meta-analysis. Sci Rep 2015; 5:12249.
  20. Takatani-Nakase T. Zinc Transporters and the Progression of Breast Cancers. Biol Pharm Bull 2018; 41(10):1517-22.
  21. Zeng YF, Sang J. Five zinc finger protein 350 single nucleotide polymorphisms and the risks of breast cancer: a meta-analysis. Oncotarget 2017; 8(63):107273-82.
  22. Bonaventura P, Benedetti G, Albarède F, Miossec P. Zinc and its role in immunity and inflammation. Autoimmun Rev 2015; 14(4):277-85.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 23, Issue 4
June 2020
Pages 24-30