Comparison of serum levels of vitamin D after mastectomy in women with and without postoperative infection: case-control study

Document Type : Original Article

Authors

1 Assistant Professor, Department of General Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Assistant Professor, Department of Infectious Diseases, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Introduction: Post-mastectomy infection can dramatically increase the duration of recovery. Considering the potential role of vitamin D in preventing infection, this study was performed with aim to compare serum levels of post-mastectomy vitamin D in women with and without postoperative infection.
Methods: This case-control study was performed on 50 women after mastectomy at Tabriz Imam Reza Hospital in 2017-2018. Demographic information and vitamin D levels (taking blood samples) were included in a researcher-made instrument containing disease-related information. Data were analyzed by SPSS software (version 20) and independent t-test and Chi-square tests. P< 0.05 was considered statistically significant.
Results: The mean of vitamin D in the infected group was 27.33 ±2.41 and in the uninfected group was 49.55±4.11 (p=0.004). Also, most patients in the infected group (48%) had vitamin D deficiency, while most subjects in the uninfected group (60%) had normal vitamin D that the difference between the two groups was significant (p=0.003).
Conclusion: Low levels of vitamin D increase the risk of infection after mastectomy in women with cancer.

Keywords


  1. De La Cruz L, Blankenship SA, Chatterjee A, Geha R, Nocera N, Czerniecki BJ, et al. Outcomes after oncoplastic breast-conserving surgery in breast cancer patients: a systematic literature review. Ann Surg Oncol 2016; 23(10):3247-58.
  2. Montazer M, Hadadi Z, Ghavami Z, Khanbabaei Gol M. Relationship of Body Mass Index with Chronic Pain after Breast Surgery in Women with Breast Cancer. Iran J Obstet Gynecol Infertil 2019; 22(8):10-18.
  3. Khanbabaei Gol M, Rezvani F, Ghavami Z, Mobaraki-Asl N. Prevalence of neuropathic pain and factors affecting sleep quality in women with breast cancer after radiotherapy. Iran J Obstet Gynecol Infertil 2019; 22(6):46-53.
  4. Aghamohamadi D, Khanbabaei Gol M. An Investigation Into the Effects of Magnesium Sulfate on the Complications of Succinylcholine Administration in Nulliparous Women Undergoing Elective Cesarean Section: A Double-Blind Clinical Trial. International Journal of Women’s Health and Reproduction Sciences 2019; 7(4):520-525.
  5. Aghamohammadi D, Mehdinavaz Aghdam A, Khanbabayi Gol M. Prevalence of Infections Associated with Port and Predisposing Factors in Women with Common Cancers Under Chemotherapy Referred to Hospitals in Tabriz in 2015. Iran J Obstet Gynecol Infertil 2019; 21(11):7-13.
  6. Stanton SE, Adams S, Disis ML. Variation in the incidence and magnitude of tumor-infiltrating lymphocytes in breast cancer subtypes: a systematic review. JAMA Oncol 2016; 2(10):1354-1360.
  7. Eghdam-Zamiri R, Khanbabayi Gol M. Effects of ginger capsule on treatment of nausea and vomiting in patients receiving cisplatin undergoing mastectomy: a randomized clinical trial. Iran J Obstet Gynecol Infertil 2020; 22(11):15-21.
  8. Rivera M, Moon W, Ozturk C, Ozturk CN. Abstract: Breast Implant Infection Can be Successfully Treated with Nonsurgical Therapy. Plast Reconstr Surg Glob Open 2017; 5(9 Suppl):56-57.
  9. Chung AM, Stein MJ, Ghumman A, Zhang J. The effect of post mastectomy radiation therapy on breast reconstruction with and without acellular dermal matrix: a systematic review and meta-analysis protocol. Systematic reviews 2019; 8(1):58.
  10. Sinha I, Pusic AL, Wilkins EG, Hamill JB, Chen X, Kim HM, et al. Late Surgical Site Infection in Immediate Implant-Based Breast Reconstruction. Plast Reconstr Surg 2017; 139(1):20-28.
  11. Scragg R, Waayer D, Stewart AW, Lawes CMM, Toop L, Murphy J, et al. The Vitamin D Assessment (ViDA) Study: design of a randomized controlled trial of vitamin D supplementation for the prevention of cardiovascular disease, acute respiratory infection, falls and non-vertebral fractures. J Steroid Biochem Mol Biol 2016; 164:318-325.
  12. Proal AD, Albert PJ, Marshall TG. Infection, autoimmunity, and vitamin D.  Infection and autoimmunity: Elsevier; 2015. p. 163-82.
  13. Yamamoto N, Suyama H, Yamamoto N, Ushijima N. Immunotherapy of metastatic breast cancer patients with vitamin D‐binding protein‐derived macrophage activating factor (GcMAF). Int J Cancer 2008; 122(2):461-7.
  14. Branca JJ, Pacini S, Ruggiero M. Effects of pre-surgical vitamin D supplementation and ketogenic diet in a patient with recurrent breast cancer. Anticancer Res 2015; 35(10):5525-32.
  15. Zeichner SB, Koru-Sengul T, Shah N, Liu Q, Markward NJ, Montero AJ, et al. Improved clinical outcomes associated with vitamin D supplementation during adjuvant chemotherapy in patients with HER2+ nonmetastatic breast cancer. Clin Breast Cancer 2015; 15(1):e1-e11.
  16. Hatse S, Lambrechts D, Verstuyf A, Smeets A, Brouwers B, Vandorpe T, et al. Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency. Carcinogenesis 2012; 33(7):1319-26.
  17. Nasser NJ, Fenig S, Ravid A, Nouriel A, Ozery N, Gardyn S, et al. Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients. NPJ Breast Cancer 2017; 3:10.
  18. Chiba A, Raman R, Thomas A, Lamy PJ, Viala M, Pouderoux S, et al. Serum vitamin D levels affect pathologic complete response in patients undergoing neoadjuvant systemic therapy for operable breast Cancer. Clin Breast Cancer 2018; 18(2):144-149.
  19. Xu J, Li H, Gu L, Zhou X. Association between vitamin D receptor poly (A) polymorphism and breast cancer risk: a meta-analysis. Tumor Biology 2014; 35(1):589-93.
  20. Mizrak Kaya D, Ozturk B, Kubilay P, Onur H, Utkan G, Cay Senler F, et al. Diagnostic serum vitamin D level is not a reliable prognostic factor for resectable breast cancer. Future Oncol 2018; 14(15):1461-7.