Comparison of the Efficacy of Granisetron-Dexamethasone versus Ondansetron-Dexamethasone in Prevention of Nausea and Vomiting following Gynecologic Laparoscopic Surgeries

Alipour, Mohammad; Milani, Soheila; Saghafi, Nafiseh; Eftekharzadeh, Sima; Khajeh Dalouei, Mohammad

doi:10.22038/ijogi.2013.1250

Comparison of the Efficacy of Granisetron-Dexamethasone versus Ondansetron-Dexamethasone in Prevention of Nausea and Vomiting following Gynecologic Laparoscopic Surgeries

Document Type : Original Article

Authors

Mohammad Alipour ¹

Soheila Milani ²

Nafiseh Saghafi ³

Sima Eftekharzadeh ²

Mohammad Khajeh Dalouei ⁴

¹ Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

² Anesthesiologist, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

³ Associate Professor, Department of Obstetrics and Gynecology, Ovulation Dysfunction Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

⁴ Associate Professor, Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/ijogi.2013.1250

Abstract

Introduction: Nausea and vomiting are the second most common complaints reported in the postoperative period and can lead to rare but serious medical complications. The aim of this study was better prevention of postoperative nausea and vomiting following gynecologic laparoscopic surgeries.
Methods: This clinical trial was done in Qhaem and Emam Reza hospital of Mashhad, Iran during 2010 and 2012. 150 patients who were candidate for gynecologic laparoscopic surgeries were divided randomly into three groups. All patients received Dexamethasone immediately after anesthesia. 15 minutes before extubation, one group were given Granisotron and second group were given Ondostron and the third group (control) were given normal saline as placebo.
The patients who had postoperative nausea and vomiting were treated with the same antiemetic drugs that they were given preopertively but with reduced dose of 25%. All patients were assessed for signs of nausea and vomiting. Data were analyzed using SPSS software version 11 and one-sample kolmogorov-Smirnov, one-way ANOVA and Kruskal-Wallis tests. P value less than 0.05 was considered significant.
Results: Vomiting in the first one hour and 1-6 hours after operation was more in Granisetron-Dexamethasone group than Ondansetron-Dexamethasone group. The difference was statistically significant between two groups (p<0.019) and the difference of vomiting was statistically significant between two groups and control group (p<0.045)
Conclusion: Granisetron-Dexamethasone is more effective than Ondansetron-Dexamethasone and or placebo in control of postoperative nausea and vomiting after gynecologic laparoscopic surgeries, 1 hour and 1-6 hours after operation. It is recommended to use these drugs pre-operatively.

Keywords

Anesthesia/General

Dexamethasone

Granisetron

Gynecologic Surgical Procedures

Ondansetron

Postoperative nausea and vomiting